Cancer Biology

Research includes:

  • Metastasis
  • Immunotherapy
  • microRNAs
  • Metabolism
  • Systemic tumor dormancy
  • Growth factor signaling
  • 3D culture systems
  • Apoptosis
  • Cell cycle
  • Cell differentiation
  • Epigenetics
  • Transcription factors

Training Group Mission:

Mission: To train the next generation of leaders in cancer research, and develop new knowledge that will translate into improved outcomes for cancer patients. Our cancer biology training program combines rigorous training basic biomedical sciences with translational research experiences in relation to human cancer. The program is in strong affiliation with the Purdue Center for Cancer Research (PCCR). We have been a National Cancer Institute-designated center for over 40 years. The PCCR and the Cancer Biology training program include research labs from numerous departments across campus all focused on graduate education in cancer research. A major goal of our program is to encourage and facilitate the development of integrated, interdisciplinary approaches by promoting collaborations within our training group and with other research areas such as pharmacology, biomedical engineering, and chemical biology.


Faculty Membership

Faculty
Research Area

Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation

The role of protein phosphatases in regulating cellular plasticity and therapeutic resistance in cancer

Epigenetic mechanisms in liver cancer pathogenesis due to chronic infection with the Hepatitis B Virus.

Obesity is associated with an increased risk of and/or mortality from several forms of cancer, including breast and colon cancer. Given that obesity rates in the U.S. are now approaching 40%, the development of mechanism-based interventions for this population could have a significant impact on public health. My research program focuses on investigating the molecular mechanisms linking obesity with increased breast and colon cancer risk and progression, with the goal of developing dietary and pharmaceutical interventions that reduce risk and improve prognoses in the obese patient population.

Role of histone methylation in gene expression and oncogenesis
Cell and developmental biology, membrane trafficking, molecular genetics, cell polarity
Structure and function of large protein complexes; Cryo-electron microscopy.

Chemical Immunology: Cell specific chemical perturbation of immune microenvironments in cancer, neurological and immunological disorders

Our major goal is to understand how the misregulation of chromatin leads to cancer progression. A major focus for the lab is on chromatin targeting subunits of chromatin remodeling complexes, in particular the heterogeneous collection of SWI/SNF chromatin remodeling complexes. We have determined that Polybromo 1 (PBRM1), a chromatin targeting subunit of the PBAF subcomplex, is important for the transcription of stress response genes in renal cancer, and that BRD9, a chromatin targeting subunit of the recently characterized GBAF (or ncBAF) subcomplex, is required for androgen receptor signaling in prostate cancer. Another focus of the lab is on the CBX chromatin targeting subunit of Polycomb repressive complex 1, which is represented by five CBX paralogs in mammals. We have made significant progress in establishing glioblastoma's dependence on CBX8 expression for viability, defining downstream targets of CBX8, and defining the contribution of the chromodomain to CBX8 targeting. Our current goal is to use our recently developed CBX8 inhibitors in combination with biochemical and proteomic approaches to connect paralog-specific biochemical function for CBX8 to a paralog-specific role in glioblastoma.

Our laboratory develops strategies that can leverage the immune system to simultaneously repair bone and control inflammation or cell viability. The overall
therapy goals are to (a) treat tumors and repair bone in tumor models and (b) treat and repair cartilage/bone in arthritis models.

Regulation of mineral metabolism, molecular actions of vitamin D in calcium metabolism and cancer prevention, gene-environment interactions influencing bone/calcium metabolism or cancer
Environmental and molecular toxicology, genomics, and cytogenetics
Macromolecular sequences and the evolution, structure and function of molecules; databases and computational tools for functional genomics

The Hall lab is generally interested in mechanisms cell cycle control that protect genome stability. Our work provides insight into how normal cells maintain genome fidelity during the complex process of cell division and how defects in the regulation of cell division can lead to various forms of genome instability and disease, including cancer.

We study the initiation, progression, and metastasis of vascular sarcomas with a focus on the role of microRNAs.
Functional genomics and systems biology
Multidrug resistance in human cancer
The Hu lab has developed an integrated research program that involves technology development, basic biological research, and clinical translation. The lab uses multiple approaches (including biochemical, structural, molecular, cellular, imaging, genetic, mice studies, 'omics', clinical patient analysis, and bioinformatics) to study several aspects of cancer. The lab focuses on clinically relevant problems and studies cancer development, progression, and mechanisms of treatment resistance. Current research in the lab is focused on the epigenetic role of protein arginine methyltransferase 5 (PRMT5) in reprogramming therapy-induced neuroendocrine differentiation in prostate, lung and pancreatic cancers and the development of novel therapeutics for cancer treatment.
Biological roles of miRNAs and their use as cancer therapeutics
Dietary Control of Adipose Development and Its Function
Epigenetics, Impacts of Chromatin on Gene Expression, DNA Replication & DNA Repair
Gene expression during mammalian development; cancer model systems
bio-organic chemistry, bioconjugate chemistry, in vitro evolution, drug discovery
Stem cell biology; Muscle development and regeneration; Signaling regulation of satellite cells; Adipose stem cell; muscle-fat interaction
Understanding how the cell nucleus directs expression and stability of the genome and how tissue architecture influences nuclear organization; development of 3D cell culture and organ-on-a-chip models for discovery of targets and cell nucleus-based readouts in cancer prevention and treatment;

Immunotherapy, A regulatory mechanism of anti-tumor immunity, A resistance mechanism of target therapy and/or immunotherapy, Antibody engineering

Roles of Polo-like kinase 1 and its interacting proteins in cell proliferation and carcinogenesis

Understanding the regulation of phospholipase C enzymes in cardiovascular disease and cancer through macromolecular structure determination and functional assays.

Biochemistry, Signal Transduction, Microbiology
MDM2, p53, cerebellar development and tumorigenesis, mouse models of human disease

In the Parkinson lab, we focus on the discovery of novel antibiotic and anticancer natural products from cryptic biosynthetic gene clusters found in soil dwelling
bacteria.

Computational chemistry and biological NMR
Microbial pathogenesis; host-parasite interactions; molecular detection and differentiation of microbial pathogens; recombinant and DNA vaccines
NeuroEngineering / Cellular Neurobiology
Signal transduction and protein Ser/Thr phosphatases
Ecology of natural systems, ecotoxicology, animal health
Drug Discovery in Cancer and Alzheimer's Disease Using Chemical Biology Tools
Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function
Cell signaling and morphogenesis in the leaf epidermis
Proteomics and biological mass spectrometry
Oncogene expression in eukaryotic cells
The focus of our research is to investigate the basic cellular mechanisms involved in regulating energy and lipid metabolism, including the roles that the enzyme pyruvate carboxylase (PC; in metastasis promotion) and vitamin D (in cancer prevention) play in stages during the development of cancer, including metastases.
We primarily study the molecular basis of GPCR-mediated signal transduction, principally via the techniques of X-ray crystallography and single particle electron microscopy. By determining atomic structures of signaling proteins alone and in complex with their various targets, we can provide important insights into the molecular basis of signal transduction and how diseases result from dysfunctional regulation. The lab is also interested in rational drug design and the development of biotherapeutic enzymes.
Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation
Signal transduction in development; mechanisms of robustness, cell fate decisions, and tissue patterning by morphogen gradients
We study metastatic breast cancer with a focus on the tumor microenvironment and development of antimetastatic therapeutics.
Signal transduction in cancer biology, early neuronal development and cancer metabolism.
1. Structures and functions of DNA G-quadruplex secondary structures. We seek to understand the molecular structures and cellular functions of the biologically relevant DNA G-quadruplexes, including those formed in the promoter regions of human oncogenes such as MYC, BCL-2, and PDGFR-b, as well as in human telomeres. 2. Protein interactions of G-quadruplexes. We work to understand the structures and cellular functions of proteins that interact with DNA G-quadruplexes, and their therapeutic targeting. 3. Targeting G-quadruplexes for anticancer drug development. DNA G-quadruplexes are emerging as a new class of cancer-specific molecular targets. We seek to discover small molecular anticancer drugs that target the DNA G-quadruplexes for oncogene suppression (e.g. MYC). We hope to combine the potency of DNA-interactive anticancer drugs with the selectivity properties of molecular-targeted approaches. 4. Structure-based rational drug design. We use structure-based rational design in combination with structural biology, biophysical, biochemical, and cellular methods for our drug development efforts. 5. Topoisomerases’ and transcription factors’ inhibitors.
Phytohormone ethylene biosynthesis and its signaling pathway in Arabidopsis thaliana
Cancer biology; Zebrafish cancer Model; Comparative oncogenomics; Evolutionary developmental biology (Evo-Devo)
Protein tyrosine phosphatases, cellular signaling mechanism, cancer biology, chemical and structural biology, drug discovery, protein structure and function

Student Membership

Ernest C. Young Hall, Room 170 | 155  S. Grant Street, West Lafayette, IN 47907-2114 | 765-494-2600

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