{"id":981,"date":"2022-09-26T19:21:52","date_gmt":"2022-09-26T19:21:52","guid":{"rendered":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/?page_id=981"},"modified":"2026-09-21T19:39:36","modified_gmt":"2026-09-21T19:39:36","slug":"neurotoxicity-of-pfas","status":"publish","type":"page","link":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/neurotoxicity-of-pfas\/","title":{"rendered":"PFAS and Neurotoxicity"},"content":{"rendered":"
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Neurotoxicity of PFAS<\/h1>\n\n\n\n

Principal Investigator(s):<\/strong> Dr. Jason Cannon
Co-Principal Investigator:<\/strong> Dr. Marisol Sep\u00falveda<\/p>\n<\/div>

\"Neuromelanin<\/figure><\/div>\n\n\n\n

Photo shows neuromelanin (purple dots) on brain.<\/em><\/p>\n\n <\/div>\n<\/div>\n <\/div>\n<\/div>\n\n

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Researchers<\/h2>\n\n\n\n
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\"Dr.<\/figure>\n<\/div>\n\n\n

Jason Cannon<\/strong>
Professor of Toxicology<\/em>
<\/sup>Purdue School of Health Sciences<\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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\"Josephine<\/figure>\n<\/div>\n\n\n

Josephine Brown<\/strong>
PhD student<\/sup><\/em>
Purdue School of Health Sciences<\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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\"Dr.<\/figure>\n<\/div>\n\n\n

Marisol Sep\u00falveda<\/strong>
Professor and Associate Head of Research<\/sup><\/em>
Purdue Forestry & Natural Resources<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n

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\"Meredith<\/figure>\n<\/div>\n\n\n

Meredith Scherer<\/strong>
MS<\/sup><\/em>
Purdue Forestry & Natural Resources<\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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\"Tyler<\/figure>\n<\/div>\n\n\n

Tyler Hoskins<\/strong>
Research Assistant Faculty<\/sup><\/em>
Purdue Forestry & Natural Resources<\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n

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Research Objectives<\/h2>\n\n\n\n

Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that were widely used in manufacturing and are now present in the environment throughout the world. It is known that various PFAS are quantifiable in human in blood, but potential adverse health outcomes remain unclear. Sentinel and non-traditional model species are useful to study potential toxicity of PFAS in order to understand the relationship between environmental and human health.<\/p>\n\n\n\n