{"id":981,"date":"2022-09-26T19:21:52","date_gmt":"2022-09-26T19:21:52","guid":{"rendered":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/?page_id=981"},"modified":"2023-10-16T16:34:30","modified_gmt":"2023-10-16T16:34:30","slug":"neurotoxicity-of-pfas","status":"publish","type":"page","link":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/neurotoxicity-of-pfas\/","title":{"rendered":"PFAS and Neurotoxicity"},"content":{"rendered":"<div id=\"pl-981\"  class=\"panel-layout\" ><div id=\"pg-981-0\"  class=\"panel-grid panel-has-style\" ><div class=\"panel-row-style panel-row-style-for-981-0\" ><div id=\"pgc-981-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-981-0-0-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"0\" ><h3 class=\"widget-title\">Neurotoxicity of PFAS<\/h3>\t\t\t<div class=\"textwidget\"><p><strong>Principal Investigator(s): <\/strong>Dr. Jason Cannon<br \/>\nCo-Principal Investigator Dr. Marisol Sep\u00falveda<\/p>\n<\/div>\n\t\t<\/div><\/div><div id=\"pgc-981-0-1\"  class=\"panel-grid-cell panel-grid-cell-empty\" ><\/div><div id=\"pgc-981-0-2\"  class=\"panel-grid-cell\" ><div id=\"panel-981-0-2-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"1\" ><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"120\" src=\"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-content\/uploads\/sites\/5\/2022\/10\/neurotoxicity-300w.jpg\" class=\"image wp-image-1229  attachment-full size-full\" alt=\"Neuromelanin in R. pipiens brain\" style=\"max-width: 100%; height: auto;\" \/><\/div><\/div><div id=\"pgc-981-0-3\"  class=\"panel-grid-cell\" ><div id=\"panel-981-0-3-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"2\" ><div class=\"panel-widget-style panel-widget-style-for-981-0-3-0\" >\t\t\t<div class=\"textwidget\"><p><em>Photo shows neuromelanin (purple dots) on brain.<\/em><\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><\/div><\/div><div id=\"pg-981-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-981-1-0\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-981-1-0\" ><div id=\"panel-981-1-0-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"3\" >\t\t\t<div class=\"textwidget\"><h3>Researchers<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1263 aligncenter\" src=\"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-content\/uploads\/sites\/5\/2022\/10\/cannon-jason-250h.jpg\" alt=\"Dr. Jason Cannon\" width=\"200\" height=\"250\" \/><\/p>\n<p style=\"text-align: center;margin: 0px 5px 30px 4px\">Jason Cannon, Professor of Toxicology<br \/>\nPurdue School of Health Sciences<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1409 aligncenter\" src=\"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-content\/uploads\/sites\/5\/2022\/11\/Sepulveda-UP-Michigan-May-2022.jpg\" alt=\"Dr. Marisol Sepulvada holding a fish.\" width=\"200\" height=\"250\" \/><\/p>\n<p style=\"text-align: center;margin: 0px 5px 30px 4px\">Marisol Sep\u00falveda, Professor and Associate Head of Research<br \/>\nPurdue Forestry &amp; Natural Resources<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1186 aligncenter\" src=\"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-content\/uploads\/sites\/5\/2022\/09\/hoskins-tyler.png\" alt=\"Tyler Hoskins\" width=\"200\" height=\"250\" \/><\/p>\n<p style=\"text-align: center;margin: 0px 5px 30px 4px\">Tyler Hoskins, Research Assistant Faculty<br \/>\nPurdue FNR<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pgc-981-1-1\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-981-1-1\" ><div id=\"panel-981-1-1-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"4\" ><div class=\"panel-widget-style panel-widget-style-for-981-1-1-0\" >\t\t\t<div class=\"textwidget\"><p style=\"text-align: center;margin: 0px 5px 30px 4px\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1272\" src=\"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-content\/uploads\/sites\/5\/2022\/10\/brown-josephine-250h.jpg\" alt=\"Josephine Brown\" width=\"169\" height=\"211\" \/>Josephine Brown, PhD student<br \/>\nPurdue School of Health Sciences<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1266\" src=\"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-content\/uploads\/sites\/5\/2022\/10\/scherer-meredith-250h.jpg\" alt=\"Meredith Scherer\" width=\"169\" height=\"211\" \/><\/p>\n<p style=\"text-align: center;margin: 0px 5px 30px 4px\">Meredith Scherer, MS<br \/>\nPurdue FNR<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><\/div><div id=\"pgc-981-1-2\"  class=\"panel-grid-cell\" ><div class=\"panel-cell-style panel-cell-style-for-981-1-2\" ><div id=\"panel-981-1-2-0\" class=\"so-panel widget widget_text panel-first-child\" data-index=\"5\" >\t\t\t<div class=\"textwidget\"><h3>Research Objectives<\/h3>\n<p>Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals that were widely used in manufacturing and are now present in the environment throughout the world. It is known that various PFAS are quantifiable in human in blood, but potential adverse health outcomes remain unclear. Sentinel and non-traditional model species are useful to study potential toxicity of PFAS in order to understand the relationship between environmental and human health.<\/p>\n<ul>\n<li><i>R. pipens<\/i> brains contain neuromelanin, a pigment present in humans and not rodents and thought to mediate response to toxicants<\/li>\n<li>Preliminary data suggests altered neurotransmitter levels in brains of <i>R. pipiens <\/i>exposed to PFOS<\/li>\n<li>Studying effects of PFOS on dopamine and other neurotransmitters<\/li>\n<li>Animal model: <i>Rana pipiens<\/i><\/li>\n<\/ul>\n<p><a href=\"https:\/\/www.mdpi.com\/2305-6304\/8\/2\/42\" target=\"_blank\" rel=\"noopener\">Per- and Polyfluoroalkyl Substances (PFAS) Neurotoxicity in Sentinel and Non-Traditional Laboratory Model Systems: Potential Utility in Predicting Adverse Outcomes in Human Health<\/a><br \/>\nMultidisciplinary Digital Publishing Institute (MDPI), open access journals.<\/p>\n<\/div>\n\t\t<\/div><div id=\"panel-981-1-2-1\" class=\"widget_text so-panel widget widget_custom_html panel-last-child\" data-index=\"6\" ><div class=\"textwidget custom-html-widget\"><a href=\"https:\/\/www.nih.gov\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1046\" src=\"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-content\/uploads\/sites\/5\/2022\/09\/logo.png\" alt=\"National Institutes of Health\" width=\"126\" height=\"141\" \/><\/a><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Principal Investigator(s): Dr. Jason Cannon Co-Principal Investigator Dr. Marisol Sep\u00falveda Photo shows neuromelanin (purple dots) on brain. Researchers Jason Cannon, Professor of Toxicology Purdue School of Health Sciences Marisol Sep\u00falveda, Professor and Associate Head of Research Purdue Forestry &amp; Natural<\/p>\n","protected":false},"author":55,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-981","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/pages\/981","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/users\/55"}],"replies":[{"embeddable":true,"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/comments?post=981"}],"version-history":[{"count":45,"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/pages\/981\/revisions"}],"predecessor-version":[{"id":1743,"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/pages\/981\/revisions\/1743"}],"wp:attachment":[{"href":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/wp-json\/wp\/v2\/media?parent=981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}