{"id":859,"date":"2022-09-12T20:09:05","date_gmt":"2022-09-12T20:09:05","guid":{"rendered":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/?page_id=859"},"modified":"2023-10-16T16:35:14","modified_gmt":"2023-10-16T16:35:14","slug":"pfas-toxicity-to-amphibians","status":"publish","type":"page","link":"https:\/\/www.purdue.edu\/fnr\/sites\/sepulveda\/pfas-toxicity-to-amphibians\/","title":{"rendered":"PFAS Amphibians"},"content":{"rendered":"

PFAS Toxicity to Amphibians<\/h3>\t\t\t

Principal Investigator(s): Dr. Marisol Sep\u00falveda<\/p>\n<\/div>\n\t\t<\/div><\/div>

\"Spotted<\/div><\/div><\/div><\/div>
\t\t\t

Researchers<\/h3>\n

\"Elizabeth<\/p>\n

Elizabeth Allmon, PhD
\nPurdue FNR<\/p>\n

\"Y.<\/p>\n

Youn Jeong Choi, Analytical Chemist
\nPurdue Agronomy<\/p>\n

\"J.<\/p>\n

Jason Conder, GeoSyntec
\nNew York<\/p>\n

\"Z.<\/p>\n

Zachary Pandelides, GeoSyntec
\nLouisiana<\/p>\n

\"Dr.<\/p>\n

Marisol Sep\u00falveda, Professor and Associate Head of Research
\nPurdue Forestry & Natural Resources<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div>

\t\t\t

 <\/p>\n

\"Matt<\/p>\n

Matt Hamilton, Research Scientist & Lab Manager
\nPurdue FNR<\/p>\n

\"Tyler<\/p>\n

Tyler Hoskins, Research Assistant Faculty
\nPurdue FNR<\/p>\n

\"Dr.<\/p>\n

Jason Hoverman, Professor
\nPurdue FNR<\/p>\n

\"Linda<\/p>\n

Linda Lee, Professor
\nPurdue Environmental and Ecological Engineering & Agronomy<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><\/div>

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Research Objectives<\/h3>\n

The main goal of this research, is to develop toxicity reference values (TRVs) and bioconcentration factors (BCFs) for perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), 6:2 fluorotelomer sulfonate (6:2 FTS) and perfluorohexane sulfonate (PFHxS) in three main amphibian groups (toads, frogs and salamanders). We completed close to 20 experiments exposing different amphibian species to four PFAS using different exposure routes and length of exposure. Major findings include: PFOS bioaccumulated and the precursor 6:2 FTS metabolized; LC50s are in the thousands of ppb, several orders of magnitude above environmental levels; LOECs for effects on growth, development, and condition factor ranged between 10 \u2013 1000 ppb; and effects varied depending on the species.<\/p>\n

Developing Toxicity Reference Values (TRVs) and Bioconcentration Factors (BCFs):<\/p>\n