February 14, 2018
Professor R. Timothy Bentley, a member of the Purdue Institute for Integrative Neuroscience and Associate Professor, Neurology and Neurosurgery in the Department of Basic Medical Sciences, and his collaborators Margaret Miller, Stephanie A. Thomovsky, Deborah W. Knap, Hock Gan Heng and Aaron Cohen-Gadol (IU) recently published in the Journal of Neuro-Oncology. The research article “Immunologic and gene expression pro les of spontaneous canine oligodendrogliomas; focused on the development of spontaneous brain tumors in pet dogs as a model of human brain tumors, while providing cutting-edge surgery and treatment for these pets. PIIN provided pilot funding to obtain the glioma (brain tumor) tissues and other samples through canine brain tumor surgery.
Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas
February 13, 2018
The award recognizes Dr. Sangha as an outstanding former trainee who has achieved scientific, professional and academic excellence. Dr. Sangha will receive a gift in recognition of the award and will be hosted to deliver the Alumnus of the Year Lecture to the Hotchkiss Brain Institute this fall.
January 31, 2018
Dr. Zhongming Liu, a member of PIIN and Assistant Professor of Biomedical Engineering and Electrical & Computer Engineering and his collaborators recently published in the scientific journal, PLoS ONE. “Vagal nerve stimulation triggers widespread responses and alters large-scale functional connectivity in the rat brain.” The research project investigates the effects and mechanism of vagus nerve stimulation as a potential bioelectric treatment of neurological and peripheral disorders by using high-field functional magnetic resonance imaging. The Purdue interdisciplinary team also includes Dr. Terry Powley, Distinguished Professor of Behavioral Neuroscience and PIIN member. Jiayue Cao, the first author of this publication, received a travel award from PIIN to present these findings at the 2018 Scientific Meeting of the International Society of Magnetic Resonance for Medicine.
January 26, 2018
Riyi Shi, professor of neuroscience and biomedical engineering in the Department of Basic Medical Sciences, College of Veterinary Medicine and Weldon School of Biomedical Engineering and PIIN leadership member was featured in the Purdue TODAY.
January 26, 2018
Dr. Vikki Weake, an assistant professor in the Department of Biochemistry and PIIN member, was interviewed by Eye on Vision and The Pulse on AMI radio stations in regards to her recent publication published in npj Aging and Mechanisms of Disease journal. In these episodes, Weake discussed why blue light kills photoreceptors in fruit flies and what that could mean for research into human retinal diseases and what steps do you take to protect your eyes and eyesight? The research was performed by a Purdue interdisciplinary team of collaborators that includes Dr. Donald Ready, a professor in the Department of Biological Sciences and also a member of PIIN, and Daniel Leon-Salas, an associate professor in the School of Engineering Technology. The research project demonstrates that exposing flies to strong blue light induces oxidative stress including lipid peroxidation resulting in retinal degeneration.
Dr. Vikki Weake- interviewed by Eye on Vision and The Pulse on AMI radio stations
January 23, 2018
At the invitation of Purdue Alum and County Commissioner Phil Bane, PIIN Leadership Team Member Professor Keith Kluender attended the 22 January Meeting of the Montgomery County Commissioners to share information about sound and hearing to assist the County concerning wind farm regulations.
Dr. Keith Kluender:“Noise expert provides testimony at the Montgomery County Commissioners meeting"
January 23, 2018
Dr. Jenna Rickus, the associate vice provost for teaching and learning and professor of agricultural and biological engineering and biomedical engineering and PIIN member, was featured in the Purdue TODAY.
January 22, 2018
Christine Hrycyna, professor and department head in the Department of Chemistry, has been named a 150th Anniversary Professor by the Office of the Provost, honoring her achievements in teaching at Purdue.
PIIN member Christine Hrycyna named 150th Anniversary Professor
December 15, 2017
Lipid peroxides are generated by oxidative stress in cells and contribute to aging and neurodegenerative disease. Dr. Vikki Weake, an assistant professor in the Department of Biochemistry and Member of the Purdue Institute for Integrative Neuroscience (PIIN), studies aging in the eye and the genetic mechanisms that lead to vision loss as people age. Along with her collaborators Dr. Donald Ready, a professor in the Department of Biological Sciences and also a member of PIIN, and Daniel Leon-Salas, an associate professor in the School of Engineering Technology at Purdue, recently published in the npj Aging and Mechanisms of Disease journal. The research shows that exposing Drosophila melanogaster to strong blue light induces oxidative stress including lipid peroxidation that results in retinal degeneration.
December 15, 2017
Increased spontaneous activity and aberrant neural synchrony is thought to be the underlying cause of tinnitus. The perceived pitch of tinnitus may be dictated by frequency specific neural fibers of the subcortical pathway, or the projection of altered cortical activity by-way-of tonotopic reorganizations. Subcortical neural activity in relation to tinnitus was characterized using ABR measurements. In the present study, 11 patients (21 ears) with constant tonal tinnitus underwent a two-part experiment. Experiment 1 involved click ABR measurements and included two experimental groups: tinnitus with normal hearing from 2000-4000 Hz (GI) and tinnitus with hearing loss within the range of 2000-4000 Hz (GII). Experiment 2 utilized tone burst ABRs matched to each participant’s perceived tinnitus pitch and included two experimental groups: tinnitus with normal hearing at the tinnitus pitch (GIa) and tinnitus with hearing loss at the tinnitus pitch (GIIa). These groups were compared to a control group (GIII) of ten monaurally tested (10 ears) participants with normal hearing thresholds at 250-20000 Hz and no tinnitus. Click ABR results indicate significantly prolonged V-III IPLs for GI and GII and a significantly extended absolute V latency for GII only. Tone burst ABRs matched to tinnitus pitch revealed significantly prolonged absolute latencies and IPLs at three of the seven frequencies for GIIa. ABR threshold seeking was completed and revealed negative eHL values for two of the four different stimuli for GI and GIa and four of the eight stimuli for GII and GIIa. Click ABRs results are suggestive of upper brainstem abnormalities for both groups. While GI demonstrated prolonged V-III IPLs, no significant differences were found for GIa. This suggests that there is no frequency specific subcortical characteristic associated with tinnitus with normal hearing. Frequency specific properties for subcortical activity could not be characterized due to varying results of GIIa.
