RSVP REQUIRED: Special Lectures in Neuroscience – Professor Laurence Trussell

April 19, 2018
10:30 AM - 12:00 PM
MRGN 121



Audition –from neural circuits to perception

Laurence Trussell, Ph.D., Professor Otolaryngology, Oregon Health & Science University

Topic: "Radical transformation of neural signals by excitatory interneurons in auditory and vestibular systems"

The unipolar brush cell (UBC) is an excitatory interneuron in the cochlear nucleus and vestibular cerebellum of mammals, and in the electrosensory lobe of mormyrid electric fish.  Recent studies suggest that the UBC may be required for these systems to cancel signals associated with expected or self-generated sensory signals.  We have examined the synaptic and circuit-level features of UBCs in mice, using electrophysiology, imaging and optogenetics.  We found that UBCs can respond to synaptic input with a complex array of output, including long lasting periods of excitation, inhibition or delayed excitation.  This talk will describe the cell physiological basis for these diverse responses, and report on studies that are revealing the neural connectivity associated with each type of response.


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