Burton D. Morgan Center for Entrepreneurship

Purdue Realization and Entrepreneurship Postdoctoral and Doctoral Program 2012

Application Information

Mert Efe, mefe@purdue.edu

PREPP Post-doctoral Fellow

The goal of my fellowship is to commercialize the large strain extrusion machining (LSEM) technology that was invented in the Center for Materials Processing and Technology (Profs. S. Chandrasekar and K. Trumble). Together with my colleagues, we have formed a company, Convolutus, specializing in machinery that produces metal foils and sheets by LSEM. Traditional methods for the production of metal strips (sheets of limited width) are complicated in nature, requiring multiple processing steps, which are capital intensive for dedicated equipment and building facilities as well as energy expensive. In contrast, LSEM is capable of producing metal strips of industry standard thicknesses and lengths in a single step that reduces initial capital investments by up to 60% and reduces production costs by 20% over current technologies. This disruptive process also produces these indirect benefits: shorter lead times by as much as 40%; lowers inventory carrying costs by up to 50% and reduces energy consumption by up to 60%. During the fellowship, I will raise funds, finalize the business plan and secure IP. Once the necessary funding level is achieved, the scaling-up and commercialization project will take 3 years and the process will start creating manufacturing jobs, saving energy and costs in the US metals, machinery, and manufacturing industries.

Andrew Otte, aotte@purdue.edu

PREPP Post-doctoral Fellow

My postdoctoral work in Dr. Pinal’s lab focuses on the development of novel technologies for the manufacture and improved performance of pharmaceuticals. Most notably, my work deals with particle engineering and prefabricated dosage forms. These two technologies help address the drive towards personalized medicine, the need for pediatric formulations (see Best Pharmaceuticals for Children Act and Pediatric Research Equity Act), as well as the Quality by Design (QbD) initiative. My postdoctoral research directly addresses a strongly recognized technological need by bringing novel ways of exploiting pharmaceutical expertise. The technology has great commercialization potential and the PREPP program will help me in establishing the most effective program of activities aimed at acquiring critical data, demonstrating the functionality and versatility of the prefabricated dosage forms, ultimately bringing this technology one step closer to commercialization. Specifically, I believe this program will assist me in developing a formal understanding of the commercialization process, aiding in targeting funding opportunities, defining potential clients and market spaces, and finally, formulating a strategic business plan for further development and capitalization of this technology.

Steve Ouellette, souellet@purdue.edu

PREPP Doctoral Fellow

Protein kinases represent an important class of enzymes responsible for regulating cellular signals that control critical functions such as cell growth and death. Kinase enzymatic activity is tightly regulated under normal circumstances, but is often the driver of disease when it becomes dysregulated. Therefore many kinases are pursued in the pharmaceutical industry as druggable targets, most notably for cancer indications. The process of discovering a valid kinase drug target, developing agents to inhibit its activity, and verification that the kinase is inhibited in patients requires sensitive and specific methods to measure kinase activity. In Dr. Laurie Parker’s lab, we aim to develop these technologies using peptide-based probes to measure kinase activity in vitro and in vivo. My goals as a PREPP fellow include demonstrating feasibility of our technologies as products, developing communication devices for securing funding to support our efforts, and becoming more familiar with different aspects of technology commercialization and entrepreneurship.

Somesh Khandelwal, somesh.khandelwal@gmail.com

PREPP Doctoral Fellow

My research is focused on creating smart hybrid materials with high impact and damage resistance, ability to change mechanical properties actively and with capability to sense the extent and location of damage if any. These capabilities have already been demonstrated in both physical and numerical experiments. Ongoing research is focused on creating a commercializable product that embodies these capabilities.

Two primary industries where this product is immediately applicable are: (1) Vehicle and Body Armor, and, (2) Protective packaging. Other related industries are: (3) Impact attenuating footwear and helmets, and, (4) Damage resistant floors, wall and highway crash barriers. Such a diversified portfolio of products would also hedge against variability in any one industry, be it from reduction in military spending or downturn in construction.

The USP for our product comes from the fact that while other products offer only single function at a time, e.g. damage resistance or damage detection, our product is multifunctional.

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About Burton D. Morgan Center for Entrepreneurship

The Burton D. Morgan Center for Entrepreneurship fosters the understanding and application of entrepreneurship with faculty and students across the Purdue campus and with stakeholders throughout the State.

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