Decoding Dengue and West Nile
February 20, 2014
WEST LAFAYETTE, Ind. — A team of scientists from Purdue University and the University of Michigan have captured the structure of a protein that could lead to new treatments for dengue and West Nile viruses.
Researchers have pursued this protein for years because both its role in replication and its unique release into the bloodstream mark it as a target for treatment of infection, said Richard Kuhn, professor and department head of biological sciences and the Gerald and Edna Mann Director of the Bindley Bioscience Center at Purdue.
"Having the structure of NS1 is a huge advance in understanding, and using, the protein to our advantage," said Kuhn, who led the Purdue team involved in the work. "Understanding how the protein is designed provides an easier pathway to understanding its roles in the virus life cycle. We now know which portions of the protein to target in drug development to shut it down and stop the progression of infection."
A paper detailing the research was published in the journal Science and is available online. In addition to Kuhn, Purdue research associate Joyce Jose is a co-author.
February 18, 2015
Congratulations to Dr. Joseph Irudayaraj, Deputy Director of the Bindley Bioscience Center, for the 2015 College of Engineering, Research Excellence Award.Read Full Story
January 30, 2015
Enterovirus D68 (EV-D68) is a causative agent of recent outbreaks of respiratory illness in children in the United States. Purdue researchers have shown that pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug, binds and inhibits EV-D68, suggesting that pleconaril may be a possible drug candidate to alleviate EV-D68 outbreaks. The results were reported in the January issue of the journal Science.Read Full Story
January 12, 2015
Five Purdue University researchers received nearly $150,000 from the Trask Innovation Fund to further develop their technologies. The innovations originate from multiple disciplines and range from water purification to a drug-delivery technology.Read Full Story