Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
May 15, 2015
The Molecular Therapeutics Program (MTP) released the IDDA 2015 RFA on May 8, 2015. Please see the link for guidelines. If you have any questions, please direct them to Padma Portonovo, who is the Program Manager for the MTP at email@example.com.Read Full Story
May 8, 2015
Purdue University and Indiana University Health Arnett in Lafayette have announced a three-year collaboration agreement to promote human clinical research efforts between the two groups.Read Full Story
May 1, 2015
A Purdue University professor has been elected into the National Academy of Sciences, one of the highest honors given to a scientist in the United States.Read Full Story