Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
March 3, 2015
Located in the Bindley Bioscience Center, the powerful Bruker 7-Tesla magnetic resonance imaging machine (MRI), is the only one of its kind in Indiana.Read Full Story
February 18, 2015
Congratulations to Dr. Joseph Irudayaraj, Deputy Director of the Bindley Bioscience Center, for the 2015 College of Engineering, Research Excellence Award.Read Full Story
January 30, 2015
Enterovirus D68 (EV-D68) is a causative agent of recent outbreaks of respiratory illness in children in the United States. Purdue researchers have shown that pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug, binds and inhibits EV-D68, suggesting that pleconaril may be a possible drug candidate to alleviate EV-D68 outbreaks. The results were reported in the January issue of the journal Science.Read Full Story