Purdue researchers apply new technique to manipulate virus, make it a possible cancer treatment
November 27, 2013
WEST LAFAYETTE, Ind. — Purdue University researchers successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector.
"This virus had been known to be a good vector for delivering therapeutic cargo, however it naturally infected all kinds of cells, and these diversions would compete with what we were instructing it to target," said Richard Kuhn, the Gerald and Edna Mann Director of Purdue's Bindley Biosciences Center. "We have now overcome a major challenge by not only inserting a targeting molecule of our choice, but also successfully stripping the virus of its native entry preferences. This was a big step in unlocking the potential of developing this virus into a platform for both targeted drug delivery, where it would sneak drugs inside cancer cells, and oncolytic virotherapy, where the virus itself destroys cancer cells."
- Elizabeth K. Gardner, Writer
December 2, 2015
The Indiana CTSI-Purdue Retreat is being held at Purdue on Friday, January 8, 2016.Read Full Story
September 11, 2015
The Postdoc Challenge offers postdoctoral research associates at Indiana University, Purdue University, and the University of Notre Dame valuable proposal writing and reviewing experience in areas related to translational research through the use of one or more of the CTSI-Designated Core Facilities at these universities.Read Full Story
May 29, 2015
This RFA requests submissions of project applications for research use of human bio-specimen with longitudinal electronic medical record data. The due date for this Request for Applications is Friday, October 2, 2015. All Purdue full-time faculty members on the West Lafayette campus, regardless of tenure status, are eligible to apply. Samples will be provided free of charge to the qualified awardee(s).Read Full Story