Obesity and Cancer

Selected Proposals

Integrative 3D Tissue Models of Breast Epithelia Recapitulating Lean and Obese Microenvironments

Photo of Sophie Lelievre, Associate Professor of Cancer Pharmacology, Department of Basic Medical Sciences

Sophie Lelievre, Associate Professor of Cancer Pharmacology, Department of Basic Medical Sciences

Novel Mechanisms of Cholesterol Regulation in Prostate Cancer by Cholesterol Sulfotransferase (SULT)2B1b

Photo of Scott Crist, Research Professor of Comparative Pathobiology

Scott Crist, Research Professor of Comparative Pathobiology

Defining the role of obesity in the regulation of epithelial-mesenchymal transition (EMT) and mammary tumor stem cell traits

Photo of Ignacio Camarillo, Associate Professor of Biological Sciences

Ignacio Camarillo, Associate Professor of Biological Sciences

Targeted Metabolomic Profiling of Obesity and Breast Cancer

Photo of Nana Gletsu Miller, Assistant Professor of Nutrition Science

Nana Gletsu Miller, Assistant Professor of Nutrition Science

Call for Proposals

Proposals Due: January 15, 2013

Submit Proposal

In the past decade, substantial evidence supports a relationship between obesity and increased
risk of a variety of cancers. NCI recently identified ‘How does obesity contribute to cancer risk?’
as one of the provocative questions developed to ‘inspire interested scientists to conceive new
approaches or feasible solutions….in key areas of cancer research that are deemed important
but have not received sufficient attention.” Funding from the Walther Foundation through a
partnership between the Purdue Center for Cancer Research and the Women’s Global Health
Institute is available for pilot funding of innovative projects to stimulate collaborations in this
important research area. The project can be focused on any cancer and are not restricted to
women’s cancers.

Proposals should be focusing on how obesity contributes to cancer risk and interdisciplinary in
nature. The goal of this program is to build the foundation and stimulate interests for larger
proposals to external funding agencies. Applications to this program are expected to have a
maximum requested amount of $10,000 for one calendar year. Renewals for one year may be

Who May Apply

  1. The applicants must include at least two principle investigators (PIs) from different
    disciplines at Purdue.
  2. The PIs must be tenure or tenure track faculty at or above Assistant Professor level,
    research professors and/or clinical faculty.
  3. Applying PIs do not have to be cancer center members.

Budget Restrictions

  1. Indirect costs, such as facilities and administrative cost, are not allowed.
  2. Salaries of the PIs are not allowed.
  3. Foreign travel and clerical support are not allowed unless justified.

Application Guidelines:

  1. Face page:
    1. Title of the proposal
    2. Names and affiliations of PIs, and contact information of communicating PI
    3. Total budget amount requested
    4. Institutional support must be indicated by completion of signatures from the PIs, Department Head, and Dean
  2. Abstract: A brief summary of the work proposed, addressing specifically the roles of the investigators and how this pilot funding will facilitate external funding (~300 words or less)
  3. Research plan: (Single spaced using 11 point font and not exceed five typed pages)
    1. Specific Aims of the project
    2. Background and Significance: Emphasize obesity-related cancer risk as focus for the project, the relevant expertise of the PIs, and a description of potential translational opportunities.
    3. Preliminary results or support to show the project can be accomplished.
    4. Research strategies: Emphasize the innovative and collaborative nature of the project and provide strong evidence of the scientific integration of the contributions from the various Pls.
    5. List of milestones including plans for using preliminary results from the collaborative study to write larger proposals to external funding agencies. Identification of a specific PA/RFA for which the project is targeted is strongly encouraged.
  4. Cited Literature (not included in Research Plan page limit)
  5. Detailed budget (not exceeding $10,000 for one calendar year)
  6. Biosketches (NIH style not to exceed 4 pages for each PI)

Review criteria

  • Relevance to obesity-related cancer risk
  • Innovation and impact
  • Integration of interdisciplinary research
  • Potential to attract external funding
  • Translational potential

Submit Proposal

Nominations will be reviewed and ranked by a campus-wide committee. An online application system will be available through the Women’s Global Health Institute website (http://www.purdue.edu/womensglobalhealth) by January 15th, 2013. For questions regarding the program or the application process, please contact Luanne Bermel (lmi@purdue.edu, 496-9316) or Dorothy Teegarden (teegarden@purdue.edu, 494-8246)

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