Internal Steering Committee
Marietta L. Harrison, Ph.D.
Associate Vice-President for Research
Director, Oncological Sciences Center
Associate Director, Purdue University Center for Cancer Research
Professor of Medicinal Chemistry and Molecular Pharmacology
B.A., University of new Hampshire
Ph.D., University of Wyoming
Postdoc, Fred Hutchinson Cancer Research Center, Seattle
Research: Biochemistry and Molecular Biology
Our group studies the signaling molecule Lck, a member of the Src-family of protein tyrosine kinases. Lck is required for the activation of T-lymphocytes (T-cells) and individuals lacking functional T-cells fail to develop immune responses. In addition to protecting the body from the invasion of foreign pathogens, the immune system is thought to impact the development of cancer. In the case of cancer vaccine development, the immune system actually impedes the therapy of cancer and harnessing the immune system to aid in the prevention and treatment of tumors has been an ongoing strategy in the war against cancer. In addition to its requisite role in T cell development and activation, Lck is itself an oncogene and the forced expression of a constitutively active form in mice leads to the development of thymic tumors. Lck is thus an important player in the field of cancer immunology and a critical player in the overall immune response.
We study all aspects of the regulation and function of Lck and the signaling pathways its activation initiates. Recently, we have concentrated on its cellular localization and its modification by serine phosphorylation, which occurs following the binding of antigen to the T-lymphocyte receptor (TCR) as well as during mitosis. Our group additionally is involved in collaborative projects with both the Gibbs and Post laboratories. With the Gibbs lab, we focus on designing and synthesizing chemical analogs of palmitic acid that will prevent Lck from entering lipid rafts. With the Post lab, we focus on determining the three dimensional structure of serine phosphorylated Lck.
Honors and Credentials
- Walther Cancer Institute “Collaborator of the Year Award” 2006
- Purdue Cancer Research Award, 1988
- National Institutes of Health, National Research Service Award, 1981-1983
- Cancer Research Institute Postdoctoral Fellowship, 1980-1981
Jessica Huber, Ph.D.
Associate Professor of Speech, Language, and Hearing Sciences
B.A., English, Saint John Fisher College, Rochester, NY
M.A., Speech/Lang Path, University at Buffalo
Ph.D., Speech Science, University at Buffalo
Research: Speech Science
Professor Huber developed a new treatment for individuals with Parkinson's disease which will allow treatment to take place in everyday communication environments, rather than in the clinic, increasing the generalization of improved communication to patient's daily life even for those with moderate to severe impairments. This treatment involves the use of a small wearable device called the SpeechVive which cues patients to talk louder and clearer through the use of the Lombard Effect. She demonstrated its effectiveness in a two-site clinical efficacy study and patented the technology. Due her efforts in commercialization with assistance from partners at Purdue University, the SpeechVive will be on the market in 2013.
Professor Huber is also examining how communication and treatment gains are affected by other common tasks (for example, how speech and language production change when a person is walking and talking, rather than just sitting and talking). To achieve this research goal, Dr. Huber collaborates with other researchers in the areas of linguistics, balance, gait, and psychosocial factors along with neurologists, speech therapists, and physical therapists.
Professor Huber was recently named as the Burton D. Morgan Entrepreneur in Residence at Discovery Park. As the Entrepreneur in Residence, she assists other faculty and students who are working to translate or commercialize their ideas. She works with the leaders and staff from Discovery Park to improve the pipeline for research to impact the Indiana and U.S. economy.
Honors and Credentials
- Outstanding Graduate Faculty Instructor in the Department of Speech, Language, and Hearing Sciences 2011
- Outstanding Undergraduate Faculty Instructor in Department of Speech, Language, and Hearing Sciences 2006
- Outstanding Faculty Instructor in Department of Speech, Language, and Hearing Sciences 2005
- Honors for Outstanding Leadership and Achievement, National Student Speech Language Hearing Association 2000
Ann E. Rundell, Ph.D.
Associate Professor of Biomedical Engineering
Associate Professor of Electrical and Computer Engineering
B.S., Electrical Engineering, University of Pennsylvania
M.S., Electrical Engineering, Purdue University
Ph.D., Electrical Engineering, Purdue University
Research: Systems and Computational Biology
The Rundell research laboratory is devoted to developing effective quantitative approaches to design therapeutic and experimental strategies for the predictable manipulation of physiological and cellular processes in desired manners as well as refine the understanding of the underlying mechanisms. The research approach integrates mathematical modeling, systems analysis, and control theory directly with experiments on biological and physiological systems. The ultimate goal is to lead to a new era in tissue engineering, therapeutic design, and personalized medicine based upon validated quantitative approaches that combine theory with experiments, link the controls community with biomedical engineering, and advance mathematical and systems biology.
Honors and Credentials
- 2012 Purdue IMPACT Faculty Fellow
- 2010 Purdue Seed for Success Award
- 2010 BMEGSA Outstanding Faculty Award
- 2009 NSF Career Award
- 2009 Invited to NAE Symposium on Frontiers on Engineering Education
- 2007 IEEE Senior Member
- 2004, 2010, 2011 BME Faculty Service Award
- 1994 and 1995 Benjamin Meissner Graduate Research Fellowship
- 1993 and 1994 Magoon Award for Outstanding Graduate Teaching Assistant
Jeff Bolin, Ph.D.
Associate Vice President for Research
Professor of Biological Sciences
B.S., Biology, Purdue University
M.S., Chemistry, University of California at San Diego
Ph.D., Chemistry, University of California at San Diego
Research: Structural Biology and Biochemistry
Professor Bolin is Purdue University’s associate vice president for research. In this position, he is charged with general responsibility for various aspects of research administration, long-range and annual planning, and oversight of inter- and cross-disciplinary efforts in research. His specific responsibilities include oversight and administration of research core facilities, research development services, and Purdue’s centers policy.
Bolin is a professor of biological sciences and had served as Purdue’s associate dean of research for the College of Science 2005-09.
Bolin’s research interests include biochemistry, structural biology, and macromolecular crystallography; the structure and function of proteins, especially metalloenzymes; and current research centers on enzymes involved in the catabolism and biodegradation of aromatic and haloaromatic compounds. His research projects have been supported by awards from the National Institutes of Health, the U.S. Departments of Agriculture and Energy, the Exxon Corporation, and the Purdue Research Foundation.
Honors and Credentials
- 2012 Honored as Chief Guest, International Workshop on Transcriptomics, Proteomics, and Structural Biology, National Dairy Research Institute, Karnal, India,
- 2010 Inducted as athlete, Purdue University Intercollegiate Athletics Hall of Fame
- 2005-06 Fellow, Committee on Institutional Cooperation Academic Leadership Program
- 2004 Purdue Seeds for Success Award
- 2002 Opponent for the Doctoral Thesis of Andreas Karlson, Sveriges Lantbruksuniversitet, Uppsala, Sweden
Women’s Global Health Institute
Discovery Park, Purdue University
120E Burton D. Morgan Center for Entrepreneurship
1201 W. State Street
West Lafayette, IN 47907-2057