In cancer biology, mouse models continue to play a significant role in studies of tumor invasion, metastasis and malignant transformation, as well as in studies examining responses to therapy. Key advancements have emerged in the development of animal models for cancer biology, including the advent of orthotopic models for metastasis, transgenic animals that have developmental pathways to tumorigenesis, and state-of-the-art immunocompromised strains. Transplanted human xenografts remain a primary tool for molecular discovery and evaluation. Despite their flaws and shortcomings, xenograft mouse models have played a significant role in cancer drug development in the past three decades, and mouse models will continue to be a foundation in the war against cancer.
At the Purdue Center for Cancer Research (PCCR), where a vast pipeline of potential new agents for diagnosing and treating cancer has emerged, researchers need a productive and established facility for in vivo testing that can navigate the arena of murine cancer models.
The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies for the advancement of their projects using in vivo testing.
Services and Pricing
These costs are approximate for a 20-mouse study.
|Grant Writing||No cost|
|Tissue Collection for PK||$1,400|
|Animal Protocol Preparation||No cost|
Contact Information and Location
Bennett Elzey, PhD
Shared Resources Director
Hansen Life Sciences Research Building, Room 239