Emily Dykhuizen

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

The Dykhuizen lab is interested in using a combination of chemical and biochemical techniques to uncover the role of chromatin structure in tumor suppression. Uncovering the mechanisms of these complexes will reveal potential therapeutic avenues for cancers that currently have few therapeutic options. Three areas of research we are currently pursuing include (1) structural and biochemical analysis of chromatin modifying complexes, (2) genome-wide analysis to define the functional contribution of chromatin binding domains, such as bromodomains, PHD domains and chromodomains, within larger chromatin-modifying complexes, (2) identification an development of inhibitors of chromatin binding domains.

Selected Publications:

Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. PMID: 31755685

PBRM1 Regulates Stress Response in Epithelial Cells. Porter EG, Dhiman A, Chowdhury B, Carter BC, Lin H, Stewart JC, Kazemian M, Wendt MK, Dykhuizen EC. iScience. 2019 May 31;15:196-210. doi: 10.1016/j.isci.2019.04.027. PMID: 31077944.

Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association.Connelly KE, Weaver TM, Alpsoy A, Gu BX, Musselman CA, Dykhuizen EC. Nucleic Acids Res. 2019 Mar 18;47(5):2289-2305. doi: 10.1093/nar/gky1290. PMID: 30597065

Free PMC article. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, Dykhuizen EC. J Biol Chem. 2018 Mar 16;293(11):3892-3903. doi: 10.1074/jbc.RA117.001065. PMID: 29374058

Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. PMID: 30197195

Individual Bromodomains of Polybromo-1 Contribute to Chromatin Association and Tumor Suppression in Clear Cell Renal Carcinoma. Porter EG, Dykhuizen EC. J Biol Chem. 2017 Feb 17;292(7):2601-2610. doi: 10.1074/jbc.M116.746875. PMID: 28053089

PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma. Chowdhury B, Porter EG, Stewart JC, Ferreira CR, Schipma MJ, Dykhuizen EC. PLoS One. 2016 Apr 21;11(4):e0153718. doi: 10.1371/journal.pone.0153718. PMID: 27100670