Is an expert on osteoporosis, biomechanics, skeletal health, aging effects on bones, and exercise and bones. Is a member of American Society for Bone and Mineral Research, Orthopedic Research Society, American Society for Biomechanics and International Association for Dental Research. Has published articles on the effects of fluoridated water on bone strength, reversing excessively fragile bones, and age and bone material properties.
Research interests are ventricular fibrillation/defibrillation, electrodeless stimulation, and biomedical instrumentation. Holds several patents. Has tested the safety and comfort levels of magnetic resonance imaging. Developed a one-of-a-kind test apparatus to obtain physiological information that will enable developers of magnetic resonance imaging to produce faster, more precise MRI scans without causing discomfort to patients.
Founder and former director of Purdue's Hillenbrand Biomedical Engineering Center. Is internationally recognized as a pioneer in biomedical engineering. Has written 20 books and more than 700 scientific papers; has 22 patents. Among his innovations, developed: the first pacemaker that regulates its electrical impulses based on patient's blood pressure; electronic respiration and heart monitors for use in NASA's space program, today used for monitoring hospital patients and premature babies; and electroventilation, a way to provide artificial breathing by stimulating thoracic nerves. Has conducted research in electromyography, cardiac output, cardiac pacing, ventricular defibrillation and blood pressure. Is a fellow of numerous scientific societies, including the Institute of Electrical and Electronics Engineers, the American College of Cardiology, the Royal Society of Medicine and the American Physiological Society. Is a member of the National Academy of Engineering
Current research activities are in cardiovascular physiology, cardiac defibrillation and emergency medical care for cardiac arrest. Is past president and past chairman of the board of the Association for the Advancement of Medical Instrumentation. Is a consultant with the Bureau of Medical Devices for the Food and Drug Administration. Is a licensed physician and teaches internal medicine in the Indiana University Regional Medical Center Program. Research focuses on development of safer and more effective defibrillators, devices that restore the rhythm of an irregular heartbeat. Has published more than 300 articles and one book on biomedical engineering and instrumentation, and on cardiovascular diagnostic and therapeutic devices. Was president of the Association for Advancement of Medical Instrumentation. Also is a professor of veterinary medicine and works as a clinical professor of family medicine.
Research interests include using sound and ultrasound in medical diagnosis and therapy, especially in the respiratory system. Has expertise in the areas of biomedical acoustics, biomedical signal processing, physiological modeling and medical instrumentation. Is associated with Purdue's Hillenbrand Biomedical Engineering Center.
Has developed a number of biomaterials, polymers and drug-delivery systems to introduce medicines or artificial devices into the human body, including artificial vessels, cartilage, vocal chords and hydrogels for the controlled release of drugs. Developed an oral delivery system for insulin now undergoing animal tests. Is a founding fellow of the American Institute of Medical and Biological Engineering. Wrote or co-wrote 19 books.
Director of research, Hillenbrand Biomedical Engineering Center
Head team physician, Intercollegiate Athletics
Associate professor, veterinary physiology and pharmacology
Research activities include investigation of various treatment modalities for both acute and chronic heart failure, the development of vascular graft materials, development of biologic orthopedic tissue grafts, and the use of skeletal muscle power for cardiac assistance. Directed research to develop small intestinal submucosa (SIS), a material from pig intestines, which, when implanted in humans, serves as a scaffold for the remodeling of new tissues such as blood vessels, tendons and ligaments.
Specializes in mechanical behavior, design and remodeling of biological tissues, effect of stresses on remodeling and tissue engineering. Worked with the faculty of Hillenbrand Biomedical Engineering Center to study the physical properties and mechanical behavior -- including viscoelasticity -- of small intestinal submucosa (SIS), a material from pig intestines, which, when implanted in humans, serves as a scaffold for the remodeling of new tissues such as blood vessels, tendons and ligaments.
Is an expert on regeneration of tissues and organs. Works on development of artificial tissues to replace natural ones that are genetically defective, worn or irreparably damaged. Has studied extensively how salamanders regenerate limbs and the potential applications for regeneration of human tissue.
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