Purdue provides free anti-virus software for students, staff, and faculty. This software is available for download at https://www.purdue.edu/securepurdue/login/?location=/securepurdue/download/index.cfm&urlparam=
.DAT files are the virus definitions that allow the Anti-virus software to detect viruses. When new viruses are discovered, the anti-virus program must be updated with new .DAT files that are enabled to remove the newly discovered viruses.
To obtain the latest McAfee .DAT files, go to https://www.purdue.edu/securepurdue/login/?location=/securepurdue/download/index.cfm&urlparam=, login and click on ".DAT files" (on the left hand toolbar).
Yes, detailed instructions can be found at: https://www.purdue.edu/securepurdue/files/manuals/McAfeeAutoupdate.pdf