Funding Opportunities

Ralph W. and Grace M. Showalter Research Trust Award Recipients

2013

Each Showalter recipient was awarded $75,000

  • Chun-Ju (Alice) Chang, Basic Medical Sciences, “Noninvasive Imaging of miR-200c as a Biomarker for Early Detection of Aggressive Breast Cancer”
  • Joseph T. Kappock, Biochemistry, “Tracking an Iron-sulfur Cluster through the Cytoplasm through a Novel Yeast Metabolic Screen”
  • Yue Wu, Chemical Engineering, “Reduction of Heat Pollution in Water from Power Industry Using Thermoelectric-based Refrigeration”
  • Jason Cannon, Health Sciences, “Mechanisms of PhlP-mediated Neurotoxicity and Relevance to Parkinson’s Disease”
  • Jun Chen, Mechanical Engineering, “Development of a Noninvasive, Virtual Stethoscopy Procedure”
  • Yoon Yeo, Industrial and Physical Pharmacy, “Zwitterionic Chitosan as an LPS Antagonist for the Treatment of Sepsis”
  • Haley Oliver, Food Science, “Transcriptional Regulator of Stress Survival and Virulence, ơB as a Potential Drug Target in Methicillin-resistant Staphylococcus Aureus (MRSA)”
  • GuangJun Zhang, Comparative Pathobiology, “Identify Novel Cancer Driver Genes on Chromosome 4q and 12q in Human Malignant Peripheral Nerve Sheath Tumors”
  • Mingji Dai, Chemistry, “Targeting Cancer with Natural and Synthetic Hydropyran/Hydrofuran-containing Macrolides”
  • Silvia Stan, Nutrition Science, “Effect of Garlic-derived Bioactive Compound Diallyl Trisulfide (DATS) on Pancreatic Cancer Stem Cells”

2012

  • Bryan W. Boudouris, chemical engineering, “Synthesis and Microstructural Characterization of Functional Block Copolymer Membranes for Enhanced Therapeutic Protein Purification,” $75,000
  • Albert Bowers and Tony R. Hazbun, medicinal chemistry and molecular pharmacology, “Harnessing Orphan Drugs: Accessing the Anticancer Activity of Thiazolyl Peptides,” $73,302
  • Ryan Drenan, medicinal chemistry and molecular pharmacology and Julia A. Chester, psychological sciences, “Nicotinic Acetylcholine Receptors as Therapeutic Targets in Parkinson's Disease,” $75,000
  • Yava Jones, comparative pathobiology, Doug LaCount, medicinal chemistry and molecular pharmacology, V. Jo Davisson, medicinal chemistry and molecular pharmacology and Harm HogenEsch , school of veterinary medicine, “Selective Antagonism of v-ATPase to Treat Viral Infection,” $75,995
  • Shihuan Kuang, animal sciences and Riyi Shi, basic medical sciences, “Bioactive Scaffolds for Highly Efficient Muscle Regeneration,” $75,000
  • Wanqing Liu, medicinal chemistry and molecular pharmacology and Min Zhang, statistics, “A Genome-wide Integrated Analysis of MicroRNAs in Human Hepatic Fat Accumulation,” $75,000
  • Amy Lossie, animal sciences and Joseph Irudayaraj, agricultural and biological engineering, “Quantification and Real-time Imaging of Pre-MicroRNAs/mRNAs in Live Cells Using Super-Resolution,” $75,000
  • Russell Main, basic medical sciences, “Estrogen Receptor Beta is Critical in Governing Skeletal Growth and the Anabolic Response to Mechanical Stimuli,” $74,947
  • Kinam Park, biomedical engineering, “Glucose Detection in Exhaled Breath Condensate,” $60,000
  • Mohamed Seleem, comparative pathobiology and Mark Cushman, medicinal chemistry and molecular pharmacology, “Development of Novel Antimicrobial Compounds Against Multidrug Resistance Bacterial Pathogens, Including Methicillin-Resistant Staphylococcus Aureus (MRSA),” $75,000

2011

  • Kinam Park, Distinguished Showalter Professor, Biomedical Engineering, “Drug-eluding Balloon for Cardiovascular Diseases,” $60,000
  • Bennett Elzey, Comparative Pathobiology, “A Synthetic Lethal Interaction between Plk1 and PTEN in Prostate Cancer,” $75,000
  • Chongli Yuan, Chemical Engineering, “Effects of Chromosome Structure on Gene Transcription Activity,” $75,000
  • M. Fernanda San Martin-Gonzalez, Food Science, “Bacteriophage Coatings of Seeds for Increased Food Safety,” $60,761
  • Xiaoqi Liu, Biochemistry, “Plk1 in Gemcitabine Resistance of Pancreatic Cancer,” $75,000
  • Corey Neu, Biomedical Engineering, “Magnetic Resonance Instrumentation for Single Cell Microscopy and Spectroscopy,” $75,000
  • David Colby, Medicinal Chemistry & Molecular Pharmacology, “Fluorinated Molecules for the Treatment of Drug Addiction,” $75,000
  • Kee-Hong Kim, Food Science, “Role of Glycated Dietary Proteins in Lipid Dysfunction of Adipose Tissue  and Muscle in Aging,”  $75,000
  • Yulia Pushkar, Physics, “Analysis of Molecular Mechanisms of Adult Neurogenesis and Brain Repair by Synchrotron Based Biomedical X-ray Imaging and Spectroscopy,” $66,000
  • Teimour Maleki, Birck Nanotechnology, Discovery Park, “Photo-Electrochemical oxygenation of retinal Ischemic Tissue through Targeted Metallic Nanowire Delivery to the Hypoxic Cell,” $66,000

2010

  • Kolapo M. Ajuwon, animal sciences, “The Role of Maternal and Infant Nutrition on Epigenetic Regulation of Metabolic,” $75,000
  • Gabriel J. Bowen, earth & atmospheric sciences, “Hydrological Controls on Nitrogen Dynamics in Artificially Drained Agricultural Watersheds,” $75,000
  • David A. Colby, medicinal chemistry & molecular pharmacology, “Natural Products and Structurally-Related Derivatives for the Treatment of Parkinson's Disease,” $75,000
  • Jennifer L. Freeman, health sciences, “Alteration of Reelin — a Nerve Growth Regulatory Gene by Low Dose Lead (Pb) Exposure: A Novel Mechanism of the "Fetal Origin of Neurological Disorders,” $75,000
  • Joseph P. Garner, animal science, “A Novel Rat Model of Pre-Diagnosis Cognitive Symptoms in Parkinson's Disease,” $75,000
  • Julia Kirshner, biological sciences, “Nonlinear Optical Imaging to Measure Dynamics of Bone Marrow Colonization in a Novel 3-D Culture Model of Breast Cancer Metastasis,” $75,000
  • Yuk Fai Leung and Daisuke Kihara, biological sciences, computer science/biological sciences, “Elucidating Genetic Pathways for Curing Retinal Degeneration” $75,000
  • R. Timothy Bentley, veterinary clinical science, “Canine Glioma Cancer Stem Cells as a New Translational Cancer Model,” $72,000  
    This application was reduced by the amount of travel expenses claimed for a meeting in Aspen, Colorado, an upscale meeting location. The Selection Committee is sensitive, in a time of austerity, to avoid any appearance that Showalter funds are used for investigator recreation.
  • Brian R. Overholser, pharmacy practice, “Calcium-Dependent Regulation of a Cardiac Voltage-Gated Potassium Channel: Mechanisms Underlying a Trial Fibrillation during Heart Failure,” $63,000  
    This grant was made with funds remaining at the end of the analysis of Purdue proposals. There was not enough funding in the allocated $720,000 total to allow greater than the $63,000 grant. The Selection Committee assumed that adjustments could be made in the grant proposal and that useful and good work would result even though funding is slightly lower than requested.
  • Kinam Park, biomedical engineering, “Microcapsules for Long-Term Protein Delivery,” $60,000

2009

  • Kinam Park — $60,000, biomedical engineering, “In-vitro Drug Screening for Endothelial Growth.”
  • Joseph Ogas and Yuk Fai Leung — $75,000, biochemistry, biological sciences, “Role of the CHD5 Chromatin Remodeler in Zebrafish Development — a Potential Tumorigenesis Model.”
  • Kee-Hong Kim, Ji-Xin Cheng, and Mario Ferruzzi — $75,000, food sciences, biomedical engineer­ing, “Anti-obese Function of Curcumin.”
  • David Umulis, Chang Lu, James Clemens, Ji-Xin Cheng, and Gregery T. Buzzard — $75,000, agricultural and biological engineering, biomedical engineering, mathematics, “Live Imaging and Computational Analysis of Bone Morphogenetic Proteins in Drosophila Embryos.”
  • Ji-Xin Cheng and Sophie Lelievre — $75,000, biomedical engineering, basic medical sciences, “High-Throughput Screening of Breast Cancer Risk Factors via Real Time Imaging of Three-dimensional Culture of Phenotypically Normal Epithelium.”
  • Julie Liu — $64,000, chemical engineering, “Spatially Patterned Vasculature for Tissue Engineering.”
  • Sean Newcomer and Christopher Bidwell — $75,000, health and kinesiology, animal sciences, “Influence of Gene Expression on the Development and Progression of Atherosclerosis.”
  • Laurie J. Parker and Jan-Christophe Rochet — $75,000, medicinal chemistry and molecular pharmacology, “Impact of Neuronal Microenvironment and Kinase Inhibitors on Apoptosis-related Neurodegeneration in Alzheimer’s Disease.”
  • Ulrike Dydak and Wei Zheng — $50,000, health sciences, “New Therapeutic Treatment of Man­ganese Parkinsonism by Para-amino Salicylic Acid: Magnetic Resonance Imaging and Spectroscopy Study,”
  • Erik Barton and Douglas J. LaCount — $75,000, biological sciences, medicinal chemistry and molecular pharmacology, “Functional Analysis of Interferon-stimulated Genes.”
  • Susan Mendrysa and Stephen F. Konieczny — $50,000, basic medical sciences, biological sciences, “MDM2 as a Therapeutic Target in Pancreatic Cancer.”

2008

  • Masaru Rao, Mechanical Engineering, $74,992, "Development of Advanced Multifunctional Brain- machine Interface Devices with Enhanced Reliability for Chronic Implantation Applications"
  • SRiyi Shi, Basic Medical Sciences, $43,000, "Functional and Anatomical Nerve Fusion by PEG and Chitosan-hydrogel"
  • Yoon Yeo, Industrial & Physical Pharmacy, $75,000, "Intracellularly Transformable Nanoparticles for Drug Delivery to Multi-drug Resistant Cells"
  • Roman Pogranichniy, Comparative Pathobiology, $75,000, "Development of an Efficient, Safe Vaccine against Influenza Virus Group A (H1N1 Spanish-like flu virus) Using a Novel Plasmid Delivery Method into Swine Antigen Presenting Cells"
  • James Fleet, Foods and Nutrition, $75,000, "Genome-wide Examination of Binding Sites for Transcription Factors Responsible for Prostate Cancer Prevention"
  • Dor Ben-Amotz, Chemistry/Bindley, $75,000, "High Speed Chemical Imaging of Live Cells using a Compressive Sampling Spectrometer"
  • Greg Hockerman, Medicinal Chemistry & Molecular Pharmacology, $75,000, "Chiral g- substituted, g- Aminobutyric Acids as Potential Drugs to treat Epilepsy and Neuropathic Pain"
  • Garth Simpson, Chemistry, $75,000, "Protein Crystallization Microchip with Nonlinear Optical Readout"
  • Sylvie Brouder, Agronomy, $75,000, "Comparative Biofuel Productivity Potential and Carbon, Nitrogen, and Water Economies of Switchgrass, Miscanthus, Maize and a Low-Input, Big Bluestem-Dominated Prairie"
  • Hugo Ochoa-Acuna, Comparative Pathobiology, $75,000, "Exposure to Atrazine during Pregnancy and its Impact on Infant Health"

2007

  • Ryan Cabot and Scott Briggs, animal sciences, biochemistry, $75,000, “Alterations in Chromatin Structure and Embryonic Origins of Disease.”
  • Stacey Mobley, Andy Tao and Laura Sands, foods and nutrition, biochemistry, nursing, $75,000, “Novel Proteomic Approaches for Early Detection of Metabolis Syndrome in Obese Adults.”
  • Chris Rochet and Tony Hazbun, medicinal chemistry & molecular pharmacology, $75,000, “DJ-1: An ‘On-switch’ for Cell Survival Pathways in the Brain.”
  • M. Teresa Carvajal and Masaru Rao, industrial & physical pharmacy, mechanical engineering, $74,820, “Microfabrication of Respirable Particles as an Alternative Approach to Formulation.”
  • Donna Fekete, Daniel Szeto, Zhao-Qing Luo, Paul Collodi and Kenneth Robinson, biological sciences, animal sciences, $40,000, “Zebrafish as a Model Organism for Development and Disease.”
  • Ourania Andrisani and Xiaoq Liu, basic medical sciences, biochemistry, $75,000, “Role of Polo-like Kinase (Plk1) in Liver Cancer Development Mediated by the Hepatitis B Virus X Protein.”
  • Susan Mendrysa and Tony R. Hazbun, basic medical sciences, medicinal chemistry and molecular pharmacy, $73,405, “Identification of Novel Anti- Cancer Drug Targets in Cells Overexpressing LYar.”
  • Mark Hall, Tony R. Hazbun and Harry Charbonneau, biochemistry, Bindley Bioscience Center, medicinal chemistry and molecular pharmacy, $60,000, “Cell Cycle Regulatory Functions of the 14-3-3 Protein Family.”
  • Kevin Gurney, Paul Shepson and Ahmed Elmagarmid, earth and atmospheric science, agronomy, computer science, Purdue Climate Control Research Center, $74,591, “The “Hestia” Project: Supporting Climate Science, Policy and Planning at Purdue.”

2006

  • Cheng, Ji-Xin and Shi, Riyi, Biomedical Engineering/Basic Medical Sciences, "Better Repair of Spinal Cord Injury with Polymer Micelle based Nanomedicine," $65,000.
  • Donkin, Shawn and Teegarden, Dorothy, Animal Sciences/Foods and Nutrition, "Fetal Programming, Fructose, and Insulin Resistance," $65,000
  • Hockerman, Gregory H. and Watts, Val, Medicinal Chemistry and Molecular Pharmacology, "Potentiation of Insulin Secretion by GLP-1 Receptor Agonsits: Synergism and Forskolin and Potential Small Molecule Agonists," $75,000
  • Kane, Mike and Fleet, James and Donkin, Shawn, Computer and Information Technology/Foods and Nutrition/Animal Sciences, "Transcriptional Regulation Profiling of Genes Relevant to Prostate Cancer Progression," $73,581
  • LaCount, Douglas and Kuhn, Richard, Medicinal Chemistry and Molecular Pharmacology/Biological Sciences, "Identification of Human Protein Binding Partners of Dengue Virus Proteins," $75,000
  • Lipton, Mark and Chmielewski, Jean, Chemistry/Chemical Engineering, "Blocking Anthrax Toxin Interactions with Designed Agents," $65,000
  • Michalski, Greg and Niyogi, Devdutta and Joern, Brad, Earth and Atmospheric Sciences/Agronomy, "From Sources to Sinks - A Novel Isotopic Analysis of Nitrate Loading in Groundwater and Surface Runoff in Indiana Watersheds," $75,000
  • Mohammed, Sulma and Adamec, Jiri and Zhang, Xiang, Veterinary Pathobiology/Bindley Bioscience Center, "The Use of Proteomics to Determine Pathways of Metastasis," $65,000

2005

  • Hovis, Jennifer and Rochet, Jean-Christophe, Chemistry/Medicinal Chemistry & Molecular Pharmacology, “Understanding the Molecular Basis of Parkinson's Disease,” $75,000
  • Machaty, Zoltan and Bidwell, Christopher, Animal Sciences, “The Production of Adiponectin-Deficient Transgenic Pigs,” $75,000
  • Mittal, Suresh, Veterinary Pathobiology, “Enhancing Innate and Adaptive Immune Functions in Aging to Improve Vaccine Efficacy,” $75,000
  • Riese, David and Watts, Val, Medicinal Chemistry & Molecular Pharmacology, “Identification of a Potential Mechanism By Which Parkinson's Disease Patients Exhibit an Elevated Rick of Breast Cancer,” $75,000
  • Rochet, Jean-Christophe and Davisson, V. Jo, Medicinal Chemistry & Molecular Pharmacology, “A Link Between Oxidative Stress, Protein Aggregation, and Aging,” $75,000
  • Rundell, Ann, Biomedical Engineering, “Improved Resuscitation from Cardiac Arrest with Artificial Peripheral Resistance,” $25,000
  • Youngblood, Jeffrey and Applegate, Bruce, Materials Engineering/Food Science,” Hydrophilized Polymeric Bactericides for Medical Applications,” $75,000

2004

  • Camarillo, Ignacio and Mohammed, Sulma, Biological Sciences/Veterinary Pathobiology, “Analysis of Mammary Adipocyte gene Expression in an Obese Rat Model of Breast Cancer," $75,000
  • Engel, Bernard; Beyrouty, Craig; Lee, Linda; Mannering, Fred; and Govindaraju, Rao, Agricultural and Biological Engineering/Agronomy/Civil Engineering, "Fate and Transport of Livestock Antibiotics in Indiana Watersheds," $75,000
  • Feng, Zhilan, Mathematics, "Mathematical approaches for the study of control of emerging/re-emerging infectious diseases," $66,666
  • Fleet, James and Wu, Jing, Foods and Nutrition/Statistics, "Defining the Molecular Regulators Controlling the Development of a Functionally Mature Intestine," $75,000
  • Spurlock, Michael; Moody, Diane; and Hogenesch, Harm, Animal Sciences/Veterinary Pathobiology, "Development of a Porcine Model of the Human Metabolic Syndrome," $75,000
  • Webster, Thomas; Friedman, Alan; Fleet, James; Weaver, Connie; and Weatherman, Ross, Biomedical Engineering/Biological Sciences/Foods & Nutrition/Medicinal Chemistry and Molecular Pharmacology, "Development of Intelligent, Nanotechnology-based Materials for the Prevention and Treatment of Osteoporotic Bone," $66,666
  • Won, You-Yeon and Konieczny, Stephen Chemical Engineering/Biological Sciences, "A Novel Virus-Mimetic Approach for Gene Therapy," $66,666

2003

  • Anderson, John, Biological Sciences, "Synthesis and Characterization of a Novel Drug that Displays Specificity for the Human Immunodeficiency Virus (HIV) and Other Pathogens," $75,000
  • Andres, Ronald and Thompson, David, Chemical Engineering/Chemistry, "Development of Folic Acid Labeled Magnetic Nanoparticles for the MRI Identification and Hyperthermia Treatment of Cancer," $75,000
  • Bailey-Kellogg, Chris, Rothwell, Ian, and Laskowski, Michael, Computer Science/Chemistry, "Distribution Functions of Standard Free Energies of Protein-Protein Association," $74,800
  • Collodi, Paul, Animal Sciences, "Applications of Gene-Targeting Methods of Zebrafish," $72,500
  • Haberstroh, Karen, Biomedical Engineering, "The Use of Nano-Dimensional Bladder Tissue Replacement Constructs for the Treatment of Superficial Bladder Cancers," $75,000
  • Lee, Linda, Mannering, Fred, and Jafvert, Chad, Agronomy/Civil Engineering, "Occurrence and Fate of Emerging Organic Contaminants in Land-Applied Municipal Biosolids," $74,900
  • Rundell, Ann and Forney, James, Biomedical Engineering/Biochemistry, "Development of a Cell Based Pathogen Detection Biosensor Exploiting the Selective Activation of Innate Immune Cells," $75,000

2002

  • Chen, Jue, Kuhn, Richard, and Rossmann, Michael, Biological Sciences, "Molecular Mechanism of Flavivirus Entry," $99,500
  • Golden, Barbara, Biochemistry, "Analysis of Virus Packaging Signals and Their Implications for Antiviral Drug Development," $100,000
  • Rao, P. Suresh; Jafvert, Chad; Hua, Inez; and Lee, Linda, Civil Engineering/Agronomy, "Innovative Technologies for Accelerated Groundwater Cleanup and Remediation Performance Assessment at Contaminated Sites," $99,952
  • Shepson, Paul and McMillin, David, Earth & Atmospheric Sciences/Chemistry, "Studies of the Impact of Atmospheric Nitrogen Deposition on the Sequestration of Carbon Dioxide by North American Forests," $100,000
  • Simpson, Garth, Chemistry, "Dielectrophoretic Force Microscopy for Ultrahigh Resolution Imaging in Solution," $100,000

2001

  • Amass, Sandra, Veterinary Clinical Sciences, "Animal Agroterrorism: Biosecurity Procedures for Emergency Responders," $83,000
  • Bidwell, Christopher; Aref, Walid; Doerge, Rebecca; McIntyre, Lauren; Moody, Diane; and Spurlock, Michael, Animal Sciences/Computer Science/Agronomy, "Functional Genomics for Animal Research," $83,000
  • Brouder, Sylvie and Turco, Ronald, Agronomy/Environmental Sciences & Engineering Institute [ESEI], "Functional Ecology of E. coli in the Indiana Landscape: Implications for Environmental Management and the Protection of Water Quality and Human Health," $83,000
  • Frankel, Steve; Haberstroh, Karen; Plesniak, Michael; Webster, Thomas; Wereley, Steve; and Xu, Lisa, Mechanical Engineering/Biomedical Engineering/, "Towards Prevention and Control of Atherosclererosis: Endothelial and Smooth Muscle Cell Response to Pulsatile Flow in Stemotic Blood Vessels," $83,000
  • Friedman, Alan; Lee, Gill; Taparowsky, Elizabeth; and Bashir, Rashid, Biological Sciences/Chemical Engineering/ Biomedical Engineering/Electrical & Computer Engineering, "Research Cluster for the Application of Synthetic DNA Analogues in Chemical Biology and Biotechnology," $83,000
  • McGough, Amy; Asai, David; Baker, Timothy; Kuhn, Richard; Rossmann, Michael; and Staiger, Christopher, Biological Sciences, "Cynamics of Biological Machines," $83,000
  • Morris, Kenneth, Industrial & Physical Pharmacy, "Dielectric Analysis Determination of the Rehydration Stability of Dehydration-Labile," $37,000
  • Wilker, Jonathan; Shi, Riyi; and Stroshine, Richard, Chemistry/Basic Medical Sciences/Agricultural & Biological Engineering, "Biological Adhesives for Surgical Applications," $83,000