OVPR Events

Date: Tuesday, November 13, 2012
Time: 4:30 PM
Place: LILY G126

Speaker: Paul L. Auer,  Division of Public Health Science, Fred Hutchinson Cancer Research Center, Seattle, WA

Title: "Associating Rare-Genetic Variants with Complex Traits"

Abstract

Recently there has been a great deal of interest in understanding the role of rare-genetic variation underlying common complex traits. To investigate rare-genetic variation, microarray based Genome Wide Association Studies have been replaced by large scale next-generation sequencing studies. Although these studies produce vastly more fine-scale information on genetic variation, they do so at significant financial, computational, and statistical costs. In this talk I will discuss some of the obstacles we face when analyzing rare-genetic data, some solutions, and a few success stories.

Associated Reading:

Jennifer Asimit and Eleftheria Zeggini. 2012. Rare Variant Association Analysis Methods for Complex Traits http://www.stat.purdue.edu/%7Edoerge/BIOINFORM.D/FALL12/Auer_Associated_Reading.pdf  . www.annualreviews.org