Friday, October 17
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Session I: Structure Function of Membrane Proteins
Chairs: Cynthia Stauffacher and Dinesh Yernool
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| 8:25am |
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Welcome by Bill Cramer |
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| 8:30-9:20am |
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William Weis, Stanford University
Structure of the beta2 adrenergic receptor |
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| 9:20-9:45am |
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Michael Rossmann, Purdue University
Structure and function of membranes that may envelope many viruses |
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| 9:45- 10:10am |
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Jue Chen, Purdue University
Crystal structure of the E. coli maltose transporter |
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| 10:10-10:35am |
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Bill Cramer, Purdue University
Structure strategies for transfer of large molecules across membranes |
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| 10:35-10:55am |
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Coffee/tea break |
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Session II: Membrane Receptors and Signaling
Chairs: Chris Staiger and Dave Nichols
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| 10:55-11:45am |
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Richard Anderson, University of Wisconsin
PIP kinases and phosphoinositide signaling |
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| 11:45am-12:20pm |
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R. Claudio Aguilar, Purdue University
Signaling functions of the endocytotic machinery |
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| 12:20-12:50pm |
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Marietta Harrison, Purdue University
Signaling from Golgi membranes in T cells |
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| 12:50-1:15pm |
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Dave Nichols, Purdue University
Molecular modeling, mutagenesis, and ligand synthesis: mapping the agonist binding domains of G protein coupled receptors |
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| 1:15 – 3:00pm |
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Lunch |
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Session III: Membrane Transport and Intercellular Trafficking
Chairs: Chris Hrycyna and Wendy Peer
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| 3:00- 3:50pm |
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Robert Tampe, Wolfgang Goethe University, Frankfurt
Structure and function of TAP, the transporter associated with antigen processing |
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| 3:50-4:15pm |
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Amy Davidson, Purdue University
Using EPR to detect conformational changes in the maltose transporter |
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| 4:15-4:40pm |
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Angus Murphy, Purdue University
The membrane-anchored M1.10 protease APM1 characterizes an IRAP-like endosomal compartment in Arabidopsis |
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| 4:40-5:05pm |
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Eric Barker, Purdue University
Exploration of drug binding sites on the antidepressant and cocaine-sensitive Serotonin transporter |
| |
| 5:05-5:25pm |
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Discussion session
Angus Murphy: moderator |
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| 5:30 – 6:15pm |
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Birck and Bindley Tours (TBA) |
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| 7:00pm |
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Session chairs take Invited and Internal Speakers to Dinner |
Saturday, October 18
|
Session IV: Emerging Applications of Membrane Technologies
Chairs: John Morgan and David Nivens
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| 9:00-9:50am |
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Horst Vogel, Ecole Polytechnique Fédérale de Lausanne
Investigating cellular signaling at the nanometer and attoliter scale |
| |
| 9:50-10:15am |
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David Thompson, Purdue University
Development of a supported membrane sensor for the detection of isoprenylcarboxymethyl transferase activity |
| |
| 10:15- 10:40am |
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Ken Ritchie, Purdue University
Single molecule imaging of the dynamic structure of membranes in living cells |
| |
| 10:40-11:05am |
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Ji-xin Cheng, Purdue University
Imaging membrane by CARS microscopy: from domains in supported bilayer to demyelination in multiple sclerosis |
| |
| 11:05- 11:20am |
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Coffee/tea break |
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“Bio-Pharma View of the Pipeline of Membrane Protein Research”
Roundtable Discussion
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| 11:20 – 12:30pm |
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Guest speakers
Mark Chiu, Abbott Laboratories
Warren MacKellar, Eli Lilly
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| |
| 12:30pm |
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End of Symposium |