Jue Chen
Outside Activities
Present talk “Structural Studies of the Maltose Transporter” at the International Symposium "Molecular Life Sciences 2011," Frankfurt am Main, Germany, Sept. 24-29, 2011.

Publications
Lin, D., Diao, J., Zhou, D., and Chen, J. (2011) Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia. Coli O157:H7, J. Biol. Chem., 286:441-449. PMCID: PMC3013003.
Kim, H. C., A. M. Steffen, M. L. Oldham, J. Chen and J. M. Huibregtse. (2011) Structure and Function of a HECT Domain Ubiquitin Binding Site. EMBO Reports, 12:334-341.

Oldham, M. L. and J. Chen (2011) Crystal structure of the maltose transporter in a pretranslocation intermediate state, Science, 332,1202-1205.

Oldham, M. L. and J. Chen (2011) Snapshots of the maltose transporter during ATP hydrolysis, Proc. Natl. Acad. Sci. U.S.A. 108:15152-15156.

William A. Cramer
Outside Activities
Discussion Panel, Conference on Applications of X-ray Femtosecond Laser, Lawrence Berkeley National Lab, January 18-21, 2011

“Impediments in traveling through membrane proteins: problems in bioenergetics and protein import,” at the Rosalind Franklin University of Medicine and Science, Evansville, IL, March 31-April 1, 2011.

Lawrence Berkeley National Lab BioEnergy, Photo- and Bio- Chemistry Site Visit, Univ. of California/Berkeley, CA., July 24-26, 2011.

Seminar: “Travels on and Within Membrane Proteins,” at the Department of Chemistry, University of Missouri, September 29, - October 1, 2011.

Invited talk: “On the rate limiting step in photosynthetic electron transport,” at the Conference on Natural and Artificial Photosynthesis, Renssalaer Polytechnic Institute, Troy, NY, November 4, 2011.

Seminar: “Structure-Function of Cytochrome bf Complex,” at the Biophysics and Computational Biology Department, University of Illinois-Champaign/Urbana, December 5, 2011.

Publications
Cramer, W. A., E. Yamashita, D. Baniulis, and S. S. Hasan. 2011. The Cytochrome b6f Complex of Oxygenic Photosynthesis; in Handbook of Metalloproteins, pp. 16-28, vol. 4 (ed. A. Messerschmidt), John Wiley & Sons; Chichester (ISBN: 978-0-470-71199-6)[BC]                                                                  
Baniulis, D., H. Zhang, E. Yamashita, T. Zakharova, S. S. Hasan, and W. A. Cramer. 2011. Purification and Crystallization of the Cyanobacterial Cytochrome b6f Complex; in Methods in Molecular Biology, Photosynthesis Research Protocols (Ed., R. Carpentier), Humana Press Inc, Totowa, NJ; 684: 65-77. [BC].

Nowaczyk MM, Wulfhorst H, Ryan CM, Souda P, Zhang H, Cramer WA, Whitelegge JP. 2011. NdhP and NdhQ: Two novel small subunits of the cyanobacterial NDH-1 complex. Biochemistry, 50: 1121-1124 (accelerated publication).

Cramer, W. A., S. S. Hasan and E. Yamashita.  2011. The Q Cycle of Cytochrome bc Complexes: a Structure Perspective (a review). Biochim. Biophys. Acta-Bioenergetics, 1807: 788-802.

Cramer, W. A., E. Yamashita, and S. S. Hasan. 2011. Structure-Function of the Cytochrome b6f Complex of Oxygenic Photosynthesis; in Encyclopedia of Biological Chemistry-2nd Edition, (eds. M. D. Lane and W. J. Lennarz), Springer, in press. [BC]

Cramer, W. A., E. Yamashita, and S. S. Hasan. 2011. The Cytochrome b6f Complex of Oxygenic Photosynthesis, in Encyclopedia of Biophysics, (ed. G. C. K. Roberts), Springer, in press. [BC]

Hasan, S. S., E. Yamashita, C. Ryan, J. Whitelegge, and W. A. Cramer. 2011. Conservation of lipid functions in cytochrome bc complexes. J. Mol. Biol. 414:145-162.

Cramer, W. A., S. D. Zakharov, E. Yamashita, S. Saif Hasan, H. Zhang, D. Baniulis, M. V. Zhalnina, G. M. Soriano, J. C. Rochet, C. Ryan, and J. Whitelegge. 2011. Membrane Proteins on Four Acts: Function precedes Structure Determination. For Methods of Membrane Protein Expression and Stabilization (ed., R. Stevens), Elsevier Press, San Diego, in press. 

Sharma, O., S. D. Zakharov, E. Yamashita, M. Zhalnina, and W. A. Cramer. 2011. Colicins in Handbook of Biologically Active Peptides, Section ed. R. E. W. Hancock), Academic Press. in press.

Hasan, S. S, S. D. Zakharov, and W. A. Cramer. 2011. Selective Reduction of the Monomer in the Dimeric Cytochrome b6f Complex. in preparation.

Cramer, W. A., S. D. Zakharov, E. Yamashita, S. Saif Hasan, H. Zhang, D. Baniulis, M. V. Zhalnina, G. M. Soriano, J. C. Rochet, C. Ryan, and J. Whitelegge. 2011. Membrane Proteins on Four Acts: Function precedes Structure Determination. For Methods of Membrane Protein Expression and Stabilization (ed., R. Stevens), Elsevier Press, San Diego, in press. 

Sharma, O., S. D. Zakharov, E. Yamashita, M. Zhalnina, and W. A. Cramer. 2011. Colicins in Handbook of Biologically Active Peptides, Section ed. R. E. W. Hancock), Academic Press. in press.

Peter Hollenbeck
Outside Activities
Invited lecture:  Dept of Biology, University of California Santa Cruz, CA, 02/14/11
Invited lecture:  Dept of Cancer and Cell Biology, University of Cincinnati, OH, 04/14/11
Platform lecture: Conference on Emerging Concepts in Neuronal Cytoskeleton, Santa Cruz, Chile, 04/26/11

Mark H. Kaplan
Outside Activities
NIH HAI study section member, 2007-2011
The Journal of Immunology Section Editor, 2007-2011
Jak-STAT, Editorial Board, 2011-present

Publications
Voorhees T, Chang J, Yao Y, Kaplan MH, Chang CH, Travers JB. (2011) Dendritic Cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions. Cellular Immunology. 267:17-22. PMC3021638

Stritesky GL, Muthukrishnan R, Sehra S, Goswami R, Pham D, Travers J, Nguyen ET, Levy DE and Kaplan MH. (2011) The transcription factor STAT3 is required for Th2 development. Immunity. 34:39-49. PMC3040244

Lei L, Zhang Y, Yao W, Kaplan MH and Zhou B. (2011) TSLP interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol. 186:2254-2261. PMC3125594

Goswami R and Kaplan MH. (2011) A Brief History of IL-9. J. Immunol.186:3283-3288. PMC3074408

Perumal NB, and Kaplan MH. (2011) Regulating IL-9 transcription in T helper cells. Trends in Immunology. 32(4):146-50. PMC3070825

Sehra S, Yao W, Nguyen ET, Ahyi AN, Barbé-Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ and Kaplan MH. (2011) Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol. 186(8):4959-66. PMC3074384

Kaplan MH, Glosson NL, Stritesky GL, Yeh N, Kinzfogl J, Rohrabaugh S, Goswami R, Pham D, Levy DE, Brutkiewicz RR, Blum JS, Cooper S, Hangoc G, and Broxmeyer HE. (2011) STAT3-dependent IL-21 production from T cells regulates hematopoietic progenitor cell homeostasis. Blood. 117:6198-6201. PMC3122943

Stritesky GL and Kaplan MH (2011) Changing the STATus quo in T helper cells. Transcription. 2:179-182. PMC3173685

Howell MD, Gao P, Kim BE, Lesley LJ, Streib JE, Taylor PA, Zaccaro DJ, Boguniewicz M, Beck LA, Hanifin JM, Schneider LC, Hata TR, Gallo RL, Kaplan MH, Barnes KC and Leung DYM. (2011) The STAT6 gene increases propensity of atopic dermatitis patients towards disseminated viral skin infections. J Allergy Clin Immunol. In press.

Jabeen R, Chang HC, Goswami R, Nutt SL and Kaplan MH. (2011) The transcription factor PU.1 regulates gd T cell homeostasis. PLoS ONE 6(7): e22189. PMC3136513

Yao W, Tepper RS and Kaplan MH. (2011) Predisposition to the development of IL-9-secreting T cells in atopic infants. J Allergy ClinImmunol. In press. NIHMSID 308523

DaSilva SC, Sahu RP, Konger RL, Perkins SM, Kaplan MH, Travers JB. (2011) Increased skin barrier disruption by sodium lauryl sulfate in mice expressing a constitutively active STAT6 in T cells. Archives of Dermatological Research. In press.

Travers JB, Kozman A, Yao Y, Ming W, Yao W, Turner MJ, Kaplan MH, Mousdicas N, Haggstrom AN and Saha C. (2011) Treatment outcomes of secondarily impetiginized pediatric atopic dermatitis lesions and the role of oral antibiotics.  Pediatric Dermatology. In press.

Richard Kuhn
Outside Activities
“Role of Membranes in Dengue Virus Infection” invited speaker at the Dengue Research Conference, A Re-Emerging Challenge: New Opportunities for Dengue Research Collaboration sponsored by NIAID, February 15-18, 2011, San Juan, Puerto Rico.

“Comparative studies of flavivirus and alphavirus assembly” invited speaker at the Distinguished Lecture Series at Georgia State University, February 24, 2011, Atlanta, Georgia.

As a Board Member attended the Virus Pathogen Resource Scientific Working Group (ViPR SWG) at the UT Southwestern Medical Center, February 24-25, 2011, Dallas, Texas.

Chair, NIH ZRG1 IDM-R(10) Study Section “Small Business: Non-HIV Anti-Infective Therapeutics Special Emphasis Panel”, March 3-4, 2011, Bethesda, MD.

“Structure and Molecular Composition of Dengue Virus” invited speaker and member in the COBRE (Center for Biomedical Research Excellence) External Advisory Committee (EAC) meeting, March 17-18, 2011, University of Hawaii at Monoa, Honolulu, HI.

Invited participant at the 2nd Annual SAB Sentinext Therapeutics meeting, May 20-26, 2011, Penang, Malaysia.

“Dengue virus: dissecting an important human pathogen” invited speaker at the “Viruses Forever” Wimmer Fest Symposium in honor of Professor Eckard Wimmer’s 75th Birthday, May 27, 2011, Wang Center, Stony Brook University, Stony Brook, N.Y.

Invited participant at the PDVI (Pediatric Dengue Vaccine Initiative) 8th Dengue Research Meeting, June 9-12, 2011, Dulles Virginia.

“Antibody mediated neutralization of flaviviruses provides insight into virion biology” invited speaker at the 45th US-Japan Cooperative Medical Science Program Joint Working Conference on Immunology and Viral Diseases, sponsored by NIAID, June 20-22, 2011, Stanford, California.

“Replication and assembly of Dengue virus” invited speaker, University of California-Davis, June 28, 2011.

Publications
Kuhn, R. J.  2011.  Chapter 12: Flaviviruses, pp. 137-147.  In N. H. Acheson (ed.), Fundamentals of Molecular Virology, 2nd edition, John Wiley & Sons, Inc.

Kuhn, R. J. 2011.  Chapter 13: Togaviruses, pp. 148-158.  In N. H. Acheson (ed.), Fundamentals of Molecular Virology, 2nd edition, John Wiley & Sons, Inc.

Mayuri, E. LaBauve, and R. J. Kuhn. 2010. Chapter 13. Novel therapeutic approaches for Dengue disease. In: Frontiers in Dengue Virus Research, eds. K. A. Hanley and S. C. Weaver, Caister Academic Press, pages 239-263.

Philip Low
Outside activities
“Detection and isolation of circulating tumor cells using receptor-targeted fluorescent dyes.” University of Puerto Rico, Humacao, Puerto Rico, January 11 – 15, 2011.

“Ligand targeted Therapeutic and Imaging Agents for Cancer and Inflammation.” Asian Medical Center Symposium on Nanotherapeutics, Seoul, Korea, February 24 – 25, 2011.

 “Ligand targeted Therapeutic and Imaging Agents for Cancer.” Mayo Clinic, Dept. of Hematology and Oncology, Rochester, NY, March 3, 2011.

 “RCBM.” University of British Columbia, Vancouver, BC, March 30, 2011.

 “Ligand targeted Therapeutic and Imaging Agents for Cancer.” Liposomes in Jerusalem 2011 Conference, Jerusalem, Israel, May 15 – 19, 2011.

 “Protein Lipidation, Signaling, and Membrane Domains.” FASEB Summer Conference, Saxton River VT, August, July 26 – 27, 2011.

 “Drug Targeting to Lung Cancer and Asthma.” Lung Development, Injury and Repair Gordon Research Conference, Newport, Rhode Island, August 15 -19, 2011.

Publications
Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.  Lu, Y.; Stinnette, T.W.; Westrick, E.; Klein, P.J.; Gehrke, M.A.; Cross, V.A.; Vlahov, I.R.; Low, P.S.; Leamon, C.P.  Arthritis Res Ther. 13:R56 (2011).

Regulation of Membrane-Cytoskeletal Interactions by Tyrosine Phosphorylation of Erythrocyte Band 3.  Ferru, E.; Giger, K.; Pantaleo, A.; Campanella, E.; Grey, J.; Ritchie, K.; Vono, R.; Turrini, F.; Low, P.S.  Blood. in press (2011).

Folate Receptor-α Expression in Respectable Hepatic Colorectal Cancer Metastases: Patterns and Significance.  D’Angelica, M.D.; Ammor, J.; Gonen, M.; Klimstra, D.S.; Low, P.S.; Murphy, L.; Weiser, M.R.; Paty, P.B.; Fong, Y.; DeMatteo, R.P.; Allen, P.; Jarnagin, W.R.; Shia, J.  Modern Pathol. In press (2011).

The effect of chemotherapy on expression of folate receptor-alpha 1 in ovarian cancer.  Crane, L.M.A.; Arts, H.J.G.; van Oosten, M.; Low, P.S.; van der Zee, A.G.J., van Dam, G.M.; Bart, J.  Cell Oncol. In press (2011).

Michael Rossmann
Outside activities
 “Virus Host Entry” presented at the Hsien and Ray Wu Symposia in Beijing, China on July 28 and 29, 2011.

“Conformational changes in enveloped viruses during maturation and fusion” presented during a visit to Tsinghua University (Beijing, China) on July 27, 2011.

“Structural changes in alphavirus envelope glycoproteins during maturation and fusion” on August 1, 2011 during the Chinese Biological Investigator Society 9th biannual meeting (July 31 – August 2, 2011) held in Zhang Jiajie, China.

“Using synchrotron radiation and electron microscopy to map the huge structural changes that occur in viruses during their life cycle” presented during the Advanced Photon Source Colloquium Series on September 7, 2011 at Argonne National Laboratory, Argonne, IL.

“Conformational changes in enveloped viruses during the viral life cycle” presented during a visit to Indiana University, Bloomington, IN on September 23, 2011.

“Conformational changes during the life cycle of flavi- and alpha-viruses” presented during a visit to The University of Nebraska-Lincoln (Lincoln, NE) on October 19, 2011.

Attended the 2011 National Academy of Science annual meeting, May 1 & 2, 2011 in Washington, DC.

Attended the Gordon Research Conference on Three-Dimensional Electron Microscopy at Colby-Sawyer College in New London, NH, June 27 – July 1, 2011.

Chaired the keynote session entitled “EM, hybrid methods” during the 22nd Congress and General Assembly of the International Union of Crystallography, August 23-28, 2011 in Madrid, Spain.

Attended the wwPDB advisory committee meeting (September 30, 2011) and the EMDB advisory committee meeting (October 3, 2011), both held at the European Bioinformatics Institute in Hinxton, UK.

Publications
Xiao, C., M. A. McKinlay, M. G. Rossmann.  2011.  Design of capsid-binding antiviral agents against human rhinoviruses.  In: RSC Biomolecular Sciences Series, No. 21, Structural Virology, M. Agbandje-McKenna and R. McKenna, eds. (London, England; Royal Society of Chemistry) Chapter 16, pp. 321-339.

Battisti, A. J., Y.-K. Chu, P. R. Chipman, B. Kaufmann, C. B. Jonsson, M. G. Rossmann.  2011.  Structural studies of Hantaan virus.  J. Virol., 85:835-841.  doi:10.1128/JVI.01847-10; PMID: 21068243; PMCID: PMC3020021.

Kaufmann, B., M. G. Rossmann.  2011.  Molecular mechanisms involved in the early steps of flavivirus cell entry.  Microbes Infect. 13:1-9.  doi:10.1016/j.micinf.2010.09.005; PMID: 20869460; PMCID: PMC3014442.

Aksyuk, A. A., M. G. Rossmann.  2011.  Bacteriophage assembly.  Viruses 3:172-203.  doi:10.3390/v3030172; PMID: 21994726; PMCID: PMC3185693.

Xiang, Y., M. G. Rossmann.  2011.  The structure of bacteriophage f29 head fibers has a supercoiled triple repeating helix-turn-helix motif.  Proc. Natl. Acad. Sci. U.S.A. 108:4806-4810.  doi: 10.1073/pnas.1018097108; PMID: 21383126; PMCID: PMC3064346.

Rossmann, M. G., A. J. Battisti, P. Plevka.  2011.  Chapter 5: Future prospects.  In Advances in Protein Chemistry and Structural Biology, Volume 82: Recent Advances in Electron Cryomicroscopy, Part B.  S. J. Ludtke and B. V. Venkataram Prasad, eds. (San Diego, CA; Academic Press), pp. 101-121. 

Kaufmann, B., M. El-Far, P. Plevka, V. D. Bowman, Y. Li, P. Tijssen, M. G. Rossmann.  2011.  Structure of Bombyx mori densovirus 1, a silkworm pathogen.  J. Virol., 85:4691-4697.  doi: 10.1128/JVI.02688-10; PMID: 21367906; PMCID: PMC3107054.

Plevka, P., S. Hafenstein, L. Li, A. D’Ambramo, Jr., S. F. Cotmore, M. G. Rossmann, P. Tattersall.  2011.  Structure of a packaging defective mutant of Minute Virus of Mice indicates that the genome is packaged via a pore at a fivefold axis.  J. Virol., 85:4822-4827.  doi: 10.1128/JVI.02598-10; PMID: 21367911; PMCID: PMC3126206.

Plevka, P., B. Kaufmann, M. G. Rossmann.  2011.  Analysis of phases in the structure determination of an icosahedral virus.  Acta Crystallogr. D Biol. Crystallogr., 67:568-577.  doi: 10.1107/S090744491101448X; PMID: 21636897; PMCID: PMC3107054.

Plevka, P.,A.J.Battisti, J.Junjhon, D.C.Winkler,H. A. Holdaway, P. Keelapang, N. Sittisombut, R. J. Kuhn, A. C. Steven, M. G. Rossmann.  2011.  Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres.  EMBO Rep.,12:602-606.  doi:10.1038/embor.2011.75; PMID: 21566648; PMCID: PMC3128282.

Boyer, M., S. Azza, L. Barrassi, T. Klose, A. Campocasso, I. Pagnier, G. Fournous, A. Borg, C. Robert, X. Zhang, C. Desnues, B. Henrissat, M. G. Rossmann, B. La Scola, D. Raoult.  2011.  Mimivirus shows dramatic genome reduction over intra-amoebal allopatric culture.  Proc. Natl. Acad. Sci. U.S.A., 108:10296-10301. doi:10.1073/pnas.1101118108; PMID: 21646533; PMCID: PMC3121840.

Fokine, A., M. Z. Islam, Z. Zhang, V. D. Bowman, V. B. Rao, M. G. Rossmann.  2011.  Structure of the three N-terminal immunoglobulin domains of the highly immunogenic outer capsid protein from a T4-like bacteriophage.  J. Virol., 85:8141-8148.  doi: 10.1128/JVI.00847-11; PMID: 21632759; PMCID: PMC3147960.

Xiao, C., M. G. Rossmann.  2011.  Structures of giant icosahedral eukaryotic dsDNA viruses.  Curr. Opin. Virol. 1:101-109.  doi: 10.1016/j.coviro.2011.06.005; PMID: 21909343; PMCID: PMC3167175.

Zhang, X., Y. Xiang, D. D. Dunigan, T. Klose, P. R. Chipman, J. L. Van Etten, M. G. Rossmann.  2011.  The structure and function of the Paramecium bursaria chlorella virus capsid.  Proc. Natl. Acad. Sci. U.S.A. 108:14837-14842.  doi: 10.1073/pnas.1107847108; PMID: 21873222; PMCID: PMC3169150.

Aksyuk, A. A., L. P. Kurochkina, A. Fokine, F. Forouhar, V. V. Mesyanzhinov, L. Tong, M. G. Rossmann.  2011.  Structural conservation of the Myoviridae phage tail sheath protein fold.  Structure, in press.

Louis Sherman
Outside activities
Development of Cyanothece as a New Model Organism for Photobiological Hydrogen Production. Genomic Sciences and Bioenergy Meeting, Washington, DC, April 11-14, 2011. 
Regulations of Autotrophic and Heterothrophic Metabolism in Synechocystis sp. Strain PCC 6803 By HIK31 Operons on both the Chromosome and Plasmid   PSYSX. American Society for Microbiology Meeting, New Orleans, LA, May 21-24, 2011.
Cyanothece, unicellular diazotophic cyanobacteria: physiology, genetics and modeling. Workshop on Cyanobacterial Metabolism: Models & Validation, Lake Geneva, WI, June 26-29, 2011. 
Carbon Storage and metabolic engineering of H2 production in the unicellular, diazotroph Cyanothece. 8th  European Workshop Molecular Biology of  Cyanobacteria, Naantali, Finland, August 28-September 1, 2011. 
Biofuels from the unicellular, diazotrophic cyanobacteria cyanothece. ESF-BU-CEBITEC Conference “Microorganoms for Bio-fuel Production from Sunlight” Bielefeld, Germany, September 18-21, 2011.

Publications
         Summerfield, T.C., Nagarajan, S. and Sherman, L.A.  2011.  Gene expression under low oxygen conditions and the role of the histidine kinase, Hik31 (Sll0790), in the cyanobacterium Synechocystis sp. PCC 6803.  Microbiology, 157:1-12.

McDermott, J.E. Oehmen, C., McCue, L.A., Hill, E., Choi, D., Stockel, J., Liberton, M., Pakrasi, H.B., and Sherman, L.A. 2011.  A model of cyclic tansciptomic behavior in the cyanobacterium Cyanothece sp. ATCC 51142.  Molecular BioSystems, 7:2407-2418.

Bandyopadhyay, A., Elvitigala, T. Welsh,E., Stöckel, J., Liberton,  M., Min, H. Sherman, L.A.,  and    Pakrasi, H.B.  2011. Novel   metabolic attributes of Cyanothece, a group of unicellular nitrogen fixing cyanobacteria. mBio 2:e00214-11.

Summerfield, TC, Toepel, J and Sherman, LA. (2011) Transcriptional Response to low O2 conditions in Synechocystis sp. Strain PCC 6803 includes induction of a gene cluster containing psbA and petC2.  Photosynthesis in the Global Perspective (Kadur, GN, editor), pp. 120-129.