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Areas of Basic & Applied Membrane Sciences
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Recent Events and Activities of the Faculty

Upcoming Events

Structural Biology/Biophysical Studies on Macromolecules and Membrane Proteins Symposium*
May 3, 2013
Venue: MRGN 121 with poster display in MRGN 102
Check the flyer for more details.
*Abstract should be sent by 04/12/13 to cgreski@purdue.edu


Jue Chen
Outside Activities

Invitation to teach BIOL 2000 to graduate students at SIBS, Peking University and Tsginghus University in China, September 21 – 28, 2012.

Attend the HHMI sponsored scientific meeting, HHMI Conference Center, Chevy Chase, Maryland, March 13-15, 2012.

Present talk, “Structural and functional studies of the maltose transporter” at the 4th FEBS Special Meeting ‘ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases,Innsbruck, Austria, March 3-9, 2012.

Present talk and attend the Gordon Conference, “Ligand Recognition and Molecular Gating,” Ventura, CA, January 15-20, 2012.

Present talk “Structural Studies of the Maltose Transporter” at the International Symposium "Molecular Life Sciences 2011," Frankfurt am Main, Germany, Sept. 24-29, 2011.

Session Chair at Gordon Research Conference on Mechanisms of Membrane Transport, June 19-24, 2011, Maine.

Attend the HHMI sponsored scientific meeting, HHMI Conference Center, Chevy Chase, Maryland, May 3-7, 2011.

Publications
Lin, D.Y-W., J. Diao, and J. Chen. 2012. Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions, PNAS, 109:1925-1930. PMCID: PMC3277528.

Lin, D., Diao, J., Zhou, D., and Chen, J. (2011) Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia. Coli O157:H7, J. Biol. Chem., 286:441-449. PMCID: PMC3013003.

Kim, H. C., A. M. Steffen, M. L. Oldham, J. Chen and J. M. Huibregtse. (2011) Structure and Function of a HECT Domain Ubiquitin Binding Site. EMBO Reports, 12:334-341.

Oldham, M. L. and J. Chen (2011) Crystal structure of the maltose transporter in a pretranslocation intermediate state, Science, 332,1202-1205.

Oldham, M. L. and J. Chen (2011) Snapshots of the maltose transporter during ATP hydrolysis, Proc. Natl. Acad. Sci. U.S.A. 108:15152-15156.

 

William A. Cramer
Outside Activities
“Lipid Functions in Cytochrome bc Complexes: an unusual event in evolution,” Conference, “How bugs kill bugs, progress and challenges in bacteriocin research,” British Biochemical Society, Nottingham, England. July 16 – 18, 2012.

“Lipid Functions in Cytochrome bc Complexes: an Odd Evolutionary Transition in a Membrane Protein Structure,” Conference on Structure-Function of Biological Membranes, Arizona State University, Phoenix, Arizona, May 13-17, 2012.

“The Cytochrome b6f Complex: an Odd Lipid Effect in Evolution; An Electrostatically Constrained Electron Transport Pathway,” Royal Society Discussion on “Structure and Dynamics of the Thylakoid Membrane,” Kavi Royal Society International Centre, Buckinghamshire, UK. May 3 – 4, 2012.

Co-Chair, Bioenergetics Symposium at the Biophysical Society Meeting, San Diego, California, February 24 – 29, 2012.

"Structure-Function (Energetic) of Hetero-Oligomeric Membrane Protein Complexes," Symposium on "Structure-Function of Hetero-Oligomeric Membrane Proteins," Bioenergetics Subgroup, Biophysical Society, San Diego, California, February 25, 2012.

"Impediments in Travel Through Biological Membranes: Problems in Bioenergetics and Protein Import," Department of Biochemistry, University of Stockholm, Stockholm, Sweden, February 13, 2012.

Seminar: “Structure-Function of Cytochrome bf Complex,” at the Biophysics and Computational Biology Department, University of Illinois-Champaign/Urbana, December 5, 2011.

 “On the rate limiting step in photosynthetic electron transport,” at the Conference on Natural and Artificial Photosynthesis, Renssalaer Polytechnic Institute, Troy, NY, November 4, 2011.

Publications
Sharma, O., S. D. Zakharov, M. V. Zhalnina, E. Yamashita, and W. A. Cramer. 2012. Colicins, in Handbook of Biologically Active Peptides (A. Kastin, ed; section ed., R. E. W. Hancock), Academic Press, in press.

Hasan, S. S. and W. A. Cramer.  2012.  On the Rate Limitation of Photosynthetic Electron Transfer in the Cytochrome b6f Complex, Physical Chemistry Chemical Physics (themed issue), in press.

Hasan, S. S. and W. A. Cramer.  2012. Lipid Functions in Cytochrome bc Complexes: an Odd Evolutionary Transition in a Membrane Protein Structure, Structure and Dynamics of the Thylakoid Membrane – a Theo Murphy Discussion Meeting (themed issue) Royal Society Philosophical Transactions B (P. Horton, guest ed.), in press.

Hasan, S. S., D. Baniulis, J. Stofleth, E. Yamashita, M. Zhalnina, S. D. Zakharov and W. A. Cramer.  2012.  Interactions of Detergents and Lipids with a α-Helical and β-Barrel Integral Membrane Proteins, and of Lipids with a “Part-Time” Helical Protein.  Current Protocols in Protein Science, in press.

Jakes, K., and W. A. Cramer. 2012. Border Crossings - Colicins and Transporters. Annual Reviews of Genetics, 46, in press.

Cramer, W. A., E. Yamashita, and S. S. Hasan. 2012. Structure-Function of the Cytochrome b6f Complex of Oxygenic Photosynthesis; in Encyclopedia of Biological Chemistry-2nd Edition, (eds. M. D. Lane and W. J. Lennarz), Springer, in press.

Cramer, W. A., E. Yamashita, and S. S. Hasan. 2012. The Cytochrome b6f Complex of Oxygenic Photosynthesis, in Encyclopedia of Biophysics, (ed. G. C. K. Roberts), Springer, in press.

Cramer, W. A., S. D. Zakharov, E. Yamashita, S. Saif Hasan, H. Zhang, D. Baniulis, M. V. Zhalnina, G. M. Soriano, J. C. Rochet, C. Ryan, and J. Whitelegge. 2011. Membrane Proteins in Four Acts: Function Precedes Structure Determination. For Methods: Membrane Protein Technologies for Structural Biology (ed., R. Stevens), 55, 415-420. Elsevier Press, San Diego.

Nowaczyk, M. M., Wulfhorst, H., Ryan, C. M., Souda, P., Zhang H., Cramer, W.  A., Whitelegge, J. P. 2011. NdhP and NdhQ: Two novel small subunits of the cyanobacterial NDH-1 complex. Biochemistry, 50: 1121-1124 (accelerated publication).

Cramer, W. A., S. S. Hasan and E. Yamashita.  2011. The Q Cycle of Cytochrome bc Complexes: a Structure Perspective (a review). Biochim. Biophys. Acta-Bioenergetics, 1807: 788-802.

Hasan, S. S., E. Yamashita, C. Ryan, J. Whitelegge, and W. A. Cramer. 2011. Conservation of lipid functions in cytochrome bc complexes. J. Mol. Biol. 414:145-162.

Robert Geahlen
Outside Activities
Molecular and Cellular Proteomics, Editorial Board, 2007-present
BBA-Molecular Cell Research, Section Editor, 2004-present
NIH Study Section, NCI-F Manpower and Training

Honors
Provost’s Award for Outstanding Graduate Mentor, 2012

Jeananne D. and James B. Chaney Research and Scholarship Achievement Award, 2011

Publications
Moon, K.D., Zhang, X., Zhou, Q., and Geahlen, R.L. (2012) The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2, BBA – Mol. Cell Res. 1823, 199-205.

Martin V.A., Wang, W.-H., Lipchik, A.M., Parker, L.L., He, Y., Zhang, S., Zhang, Z.-Y., and Geahlen, R.L. (2012) Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores, Cell. Signal. 24, 1064-1073.

Xue, L., Wang W.-H., Iliuk, A., Hu, L., Galan, J.A., Yu, S., Hans, M., Geahlen, R.L., and Tao, W.A. (2012) Sensitive Kinase Assay Linked with Phosphoproteomics for Identifying Direct Kinase Substrates, Proc. Natl. Acad. Sci. U.S.A., In press.

Galan, J., Paris, L.L., Zhang, H.-j., Adler, J., Geahlen, R.L., and Tao, W.A. (2011) Identification of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap, J. Am. Soc. Mass Spectrom. 22, 319-328.

Chen, C.-H., Martin, V.A., Gorenstein, N.M., Geahlen, R.L. and Post, C.B. (2011) Two closely-spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Mol. Cell Biol. 31, 2984-2996.

Peter Hollenbeck
Outside Activites
Invited lecture, Dept of Neuroscience, University of Minnesota School of Medicine, Minneapolis MN, 2/9/12

Review panels
United Mitochondrial Disease Foundation review panel (04/12/12)

NIH CSR Special Emphasis Panel MDCN-P(57), “Molecular and Cellular Substrates of Complex Brain Disorders (R01/R21)” 3/2/12

Publications:
Suter, D. M. & P. J. Hollenbeck. 2012.  How to Get on the Right Track.  Nat. Neurosci., 15:7-8.

Mark H. Kaplan
Outside Activities
Jak-STAT, Editorial Board, 2011-present
NIH HAI study section member, 2007-2011
The Journal of Immunology Section Editor, 2007-2011
                                   
Publications
Yao W, Tepper RS and Kaplan MH. (2012) Predisposition to the development of IL-9-secreting T cells in atopic infants. J. Allergy ClinImmunol. In press. NIHMSID 308523

DaSilva SC, Sahu RP, Konger RL, Perkins SM, Kaplan MH, Travers JB. (2012) Increased skin barrier disruption by sodium lauryl sulfate in mice expressing a constitutively active STAT6 in T cells. Archives of Dermatological Research. In press.

Travers JB, Kozman A, Yao Y, Ming W, Yao W, Turner MJ, Kaplan MH, Mousdicas N, Haggstrom AN and Saha C. (2012) Treatment outcomes of secondarily impetiginized pediatric atopic dermatitis lesions and the role of oral antibiotics, Pediatric Dermatology. In press.

Voorhees T, Chang J, Yao Y, Kaplan MH, Chang CH, Travers JB. (2011) Dendritic Cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions. Cellular Immunology. 267:17-22. PMC3021638

Stritesky GL, Muthukrishnan R, Sehra S, Goswami R, Pham D, Travers J, Nguyen ET, Levy DE and Kaplan MH. (2011) The transcription factor STAT3 is required for Th2 development. Immunity. 34:39-49. PMC3040244

Lei L, Zhang Y, Yao W, Kaplan MH and Zhou B. (2011) TSLP interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol. 186:2254-2261. PMC3125594

Goswami R and Kaplan MH. (2011) A Brief History of IL-9. J. Immunol.186:3283-3288. PMC3074408

Perumal NB, and Kaplan MH. (2011) Regulating IL-9 transcription in T helper cells. Trends in Immunology. 32(4):146-50. PMC3070825

Sehra S, Yao W, Nguyen ET, Ahyi AN, Barbé-Tuana FM, Ahlfeld SK, Snider P, Tepper RS, Petrache I, Conway SJ and Kaplan MH. (2011) Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J. Immunol. 186(8):4959-66. PMC3074384

Kaplan MH, Glosson NL, Stritesky GL, Yeh N, Kinzfogl J, Rohrabaugh S, Goswami R, Pham D, Levy DE, Brutkiewicz RR, Blum JS, Cooper S, Hangoc G, and Broxmeyer HE. (2011) STAT3-dependent IL-21 production from T cells regulates hematopoietic progenitor cell homeostasis. Blood. 117:6198-6201. PMC3122943

Stritesky GL and Kaplan MH (2011) Changing the STATus quo in T helper cells. Transcription. 2:179-182. PMC3173685

Howell MD, Gao P, Kim BE, Lesley LJ, Streib JE, Taylor PA, Zaccaro DJ, Boguniewicz M, Beck LA, Hanifin JM, Schneider LC, Hata TR, Gallo RL, Kaplan MH, Barnes KC and Leung DYM. (2011) The STAT6 gene increases propensity of atopic dermatitis patients towards disseminated viral skin infections. J. Allergy. Clin. Immunol. In press.

Jabeen R, Chang HC, Goswami R, Nutt SL and Kaplan MH. (2011) The transcription factor PU.1 regulates gd T cell homeostasis. PLoS ONE 6(7): e22189. PMC3136513 

Richard Kuhn
Outside Activities
“Replication and assembly of Dengue virus” invited speaker, University of California-Davis, June 28, 2011.

 “Antibody mediated neutralization of flaviviruses provides insight into virion biology” invited speaker at the 45th US-Japan Cooperative Medical Science Program Joint Working Conference on Immunology and Viral Diseases, sponsored by NIAID, June 20-22, 2011, Stanford, California.

Invited participant at the PDVI (Pediatric Dengue Vaccine Initiative) 8th Dengue Research Meeting, June 9-12, 2011, Dulles Virginia.

“Dengue virus: dissecting an important human pathogen” invited speaker at the “Viruses Forever” Wimmer Fest Symposium in honor of Professor Eckard Wimmer’s 75th Birthday, May 27, 2011, Wang Center, Stony Brook University, Stony Brook, N.Y.

Invited participant at the 2nd Annual SAB Sentinext Therapeutics meeting, May 20-26, 2011, Penang, Malaysia.

 “Dengue virus replication, virion assembly and structure” invited speaker, University of Colorado Anschutz Medical Campus, Department of Microbiology, Denver, CO., May 4, 2012.

Served on the Scientific Advisory Board Sentinext Therapeutics Meeting, April 30-May 1, 2012, Penang, Malaysia.

Attended and participated as member the Virus Pathogen Resource (ViPR) Scientific Working Group (SWG) meeting, April 9-11, 2012, Rockville, MD.

Attended and participated as a member of the COBRE (Center of Biomedical Research Excellence) External Advisory Committee and mini-symposium, at the University of Hawaii at Monoa, Honolulu, HI, March 13-14, 2012.

 “Dengue virus replication, virion assembly and structure” invited keynote speaker, Rio Grande American Society of Microbiology (ASM) regional meeting, Feb. 24-25, 2012, Las Cruces, NM.

 “Assembly and replication of dengue virus, invited speaker, Medical College of Wisconsin, Dept. of Microbiology and Molecular Genetics, Feb. 21, 2012, Milwaukee, WI.

 “Assembly and replication of dengue virus” invited speaker, University of Heidelberg, Jan. 17, 2012, Heidelberg, Germany.

“Dengue virus replication and their influence on the host cell” invited speaker, Paris Pasteur Institute, Jan. 16, 2012, Paris, France.

Publications
Keating, J. A., D. Bhattacharya, P-Y. Lim, M. Sharma, R. J. Kuhn, K. A. Bernard and R. Striker.  2012. Protein kinase G enhances West Nile Virus replication in mammalian cells. Submitted.

Aggarwal, M., S. Tapas, P. Preeti, P. Kumar, R. J. Kuhn, and S. Tomar.  2012.  Crystal structure of Aura virus capsid protease and its complex with dioxane: Comparative reinvestigation of the alphavirus capsid-glycoprotein interactions and dioxane inhibition.  Submitted. 

Plevka, P., R. Perera, J. Cardosa, R. J. Kuhn and M. G. Rossmann.  2012. Crystal structure of human Enterovirus 71. Science, in press.

Jose, J., L. Przybyla, T. J. Edwards, R. Perera, J. W.  Burgner, and R. J. Kuhn. 2012.  Interactions of the cytoplasmic domain of Sindbis virus E2 with nucleocapsid cores promote alphavirus budding. J. Virol., 86:2585-2599.  PMID: 22190727.

Pierson, T. C. and R. J. Kuhn.  2012.  Capturing a virus while it catches its breath. Structure 20:200-202. PMID: 22325768.

Perera, R., C. Riley, G. Isaac, A. Hopf-Jannasch, R. J. Moore, K. W. Weitz, L. Pasa-Tolic, T. O. Metz, J. Adamec and R. J. Kuhn. 2012.  Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathog. 8(3): e1002584.

Botting, C. and R. J. Kuhn.  2012.  Novel approaches to flavivirus drug discovery. Expert. Opin. Drug Discov. 7:417-428. 

Kuhn, R. J.  2011.  Chapter 12: Flaviviruses, pp. 137-147.  In N. H. Acheson (ed.), Fundamentals of Molecular Virology, 2nd edition, John Wiley & Sons, Inc.

Kuhn, R. J. 2011.  Chapter 13: Togaviruses, pp. 148-158.  In N. H. Acheson (ed.), Fundamentals of Molecular Virology, 2nd edition, John Wiley & Sons, Inc.

Philip Low
Outside activities
 “Ligand targeted Therapeutic and Imaging Agents for Cancer.” Liposomes in Jerusalem 2011 Conference, Jerusalem, Israel, May 15 – 19, 2011.

“Protein Lipidation, Signaling, and Membrane Domains.” FASEB Summer Conference, Saxton River VT, August, July 26 – 27, 2011.

“Drug Targeting to Lung Cancer and Asthma.” Lung Development, Injury and Repair Gordon Research Conference, Newport, Rhode Island, August 15 -19, 2011.

Publications
Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate.  Lu, Y.; Stinnette, T.W.; Westrick, E.; Klein, P.J.; Gehrke, M.A.; Cross, V.A.; Vlahov, I.R.; Low, P.S.; Leamon, C.P.  Arthritis Res Ther. 13:R56 (2011).

Regulation of Membrane-Cytoskeletal Interactions by Tyrosine Phosphorylation of Erythrocyte Band 3.  Ferru, E.; Giger, K.; Pantaleo, A.; Campanella, E.; Grey, J.; Ritchie, K.; Vono, R.; Turrini, F.; Low, P.S.  Blood. in press (2011).

Folate Receptor-α Expression in Respectable Hepatic Colorectal Cancer Metastases: Patterns and Significance.  D’Angelica, M.D.; Ammor, J.; Gonen, M.; Klimstra, D.S.; Low, P.S.; Murphy, L.; Weiser, M.R.; Paty, P.B.; Fong, Y.; DeMatteo, R.P.; Allen, P.; Jarnagin, W.R.; Shia, J.  Modern Pathol. In press (2011).

The effect of chemotherapy on expression of folate receptor-alpha 1 in ovarian cancer.  Crane, L.M.A.; Arts, H.J.G.; van Oosten, M.; Low, P.S.; van der Zee, A.G.J., van Dam, G.M.; Bart, J.  Cell Oncol. In press (2011). 

Sandra Rossie
Publications
Bremmer, S.C., H. Hall, J.S. Martinez, C. L. Eissler, T. H. Hinrichsen, S. Rossie, L. L. Parker, M. C. Hall, and H. Charbonneau.  2012.  Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine,  J Biol. Chem., 287:1662-9. (JBC paper of the week).

Michael Rossmann
Outside activities
“Conformational changes during the life cycle of flavi- and alpha-viruses” presented during a visit to The University of Nebraska-Lincoln (Lincoln, NE) on October 19, 2011.

Attended the wwPDB advisory committee meeting (September 30, 2011) and the EMDB advisory committee meeting, both held at the European Bioinformatics Institute in Hinxton, UK. ,October 3, 2011.

“Conformational changes in enveloped viruses during the viral life cycle” presented during a visit to Indiana University, Bloomington, IN on September 23, 2011.

“Using synchrotron radiation and electron microscopy to map the huge structural changes that occur in viruses during their life cycle” presented during the Advanced Photon Source Colloquium Series on September 7, 2011 at Argonne National Laboratory, Argonne, IL.

Chaired the keynote session entitled “EM, hybrid methods” during the 22nd Congress and General Assembly of the International Union of Crystallography, August 23-28, 2011 in Madrid, Spain.

“Structural changes in alphavirus envelope glycoproteins during maturation and fusion” on August 1, 2011 during the Chinese Biological Investigator Society 9th biannual meeting (July 31 – August 2, 2011) held in Zhang Jiajie, China.

“Virus Host Entry” presented at the Hsien and Ray Wu Symposia in Beijing, China on July 28 and 29, 2011.

 “Conformational changes in enveloped viruses during maturation and fusion” presented during a visit to Tsinghua University (Beijing, China) on July 27, 2011.

Attend the Gordon Research Conference on Three – Dimensional Electron Microscopy at Colby-Sawyer College in New London, NH, June 27 – July 1, 2011.

Attend the 2011 National Academy of Science annual meeting, Washington, DC, May 1 & 2, 2011.

Publications
Xiao, C., M. A. McKinlay, M. G. Rossmann.  2011.  Design of capsid-binding antiviral agents against human rhinoviruses.  In: RSC Biomolecular Sciences Series, No. 21, Structural Virology, M. Agbandje-McKenna and R. McKenna, eds. (London, England; Royal Society of Chemistry) Chapter 16, pp. 321-339.

Battisti, A. J., Y.-K. Chu, P. R. Chipman, B. Kaufmann, C. B. Jonsson, M. G. Rossmann.  2011.  Structural studies of Hantaan virus.  J. Virol., 85:835-841.  doi:10.1128/JVI.01847-10; PMID: 21068243; PMCID: PMC3020021.

Kaufmann, B., M. G. Rossmann.  2011.  Molecular mechanisms involved in the early steps of flavivirus cell entry.  Microbes Infect. 13:1-9.  doi:10.1016/j.micinf.2010.09.005; PMID: 20869460; PMCID: PMC3014442.

Aksyuk, A. A., M. G. Rossmann.  2011.  Bacteriophage assembly.  Viruses 3:172-203.  doi:10.3390/v3030172; PMID: 21994726; PMCID: PMC3185693.

Xiang, Y., M. G. Rossmann.  2011.  The structure of bacteriophage f29 head fibers has a supercoiled triple repeating helix-turn-helix motif.  Proc. Natl. Acad. Sci. U.S.A. 108:4806-4810.  doi: 10.1073/pnas.1018097108; PMID: 21383126; PMCID: PMC3064346.

Rossmann, M. G., A. J. Battisti, P. Plevka.  2011.  Chapter 5: Future prospects.  In Advances in Protein Chemistry and Structural Biology, Volume 82: Recent Advances in Electron Cryomicroscopy, Part B.  S. J. Ludtke and B. V. Venkataram Prasad, eds. (San Diego, CA; Academic Press), pp. 101-121. 

Kaufmann, B., M. El-Far, P. Plevka, V. D. Bowman, Y. Li, P. Tijssen, M. G. Rossmann.  2011.  Structure of Bombyx mori densovirus 1, a silkworm pathogen.  J. Virol., 85:4691-4697.  doi: 10.1128/JVI.02688-10; PMID: 21367906; PMCID: PMC3107054.

Plevka, P., S. Hafenstein, L. Li, A. D’Ambramo, Jr., S. F. Cotmore, M. G. Rossmann, P. Tattersall.  2011.  Structure of a packaging defective mutant of Minute Virus of Mice indicates that the genome is packaged via a pore at a fivefold axis.  J. Virol., 85:4822-4827.  doi: 10.1128/JVI.02598-10; PMID: 21367911; PMCID: PMC3126206.

Plevka, P., B. Kaufmann, M. G. Rossmann.  2011.  Analysis of phases in the structure determination of an icosahedral virus.  Acta Crystallogr. D Biol. Crystallogr., 67:568-577.  doi: 10.1107/S090744491101448X; PMID: 21636897; PMCID: PMC3107054.

Plevka, P. a. J. Battisti, J. Junjhon, D. C. Winkler, H. A. Holdaway, P. Keelapang, N. Sittisombut, R. J. Kuhn, A. C. Steven, M. G. Rossmann.  2011.  Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres.  EMBO Rep., 12:602-606.  doi:10.1038/embor.2011.75; PMID: 21566648; PMCID: PMC3128282.

Boyer, M., S. Azza, L. Barrassi, T. Klose, A. Campocasso, I. Pagnier, G. Fournous, A. Borg, C. Robert, X. Zhang, C. Desnues, B. Henrissat, M. G. Rossmann, B. La Scola, D. Raoult.  2011.  Mimivirus shows dramatic genome reduction over intra-amoebal allopatric culture.  Proc. Natl. Acad. Sci. U.S.A., 108:10296-10301. doi:10.1073/pnas.1101118108; PMID: 21646533; PMCID: PMC3121840.

Fokine, A., M. Z. Islam, Z. Zhang, V. D. Bowman, V. B. Rao, M. G. Rossmann.  2011.  Structure of the three N-terminal immunoglobulin domains of the highly immunogenic outer capsid protein from a T4-like bacteriophage.  J. Virol., 85:8141-8148.  doi: 10.1128/JVI.00847-11; PMID: 21632759; PMCID: PMC3147960.

Xiao, C., M. G. Rossmann.  2011.  Structures of giant icosahedral eukaryotic dsDNA viruses.  Curr. Opin. Virol. 1:101-109.  doi: 10.1016/j.coviro.2011.06.005; PMID: 21909343; PMCID: PMC3167175.

Zhang, X., Y. Xiang, D. D. Dunigan, T. Klose, P. R. Chipman, J. L. Van Etten, M. G. Rossmann.  2011.  The structure and function of the Paramecium bursaria chlorella virus capsid.  Proc. Natl. Acad. Sci. U.S.A. 108:14837-14842.  doi: 10.1073/pnas.1107847108; PMID: 21873222; PMCID: PMC3169150.

Aksyuk, A. A., L. P. Kurochkina, A. Fokine, F. Forouhar, V. V. Mesyanzhinov, L. Tong, M. G. Rossmann.  2011.  Structural conservation of the Myoviridae phage tail sheath protein fold.  Structure, in press.

Louis Sherman

Outside activities
Biofuels from the unicellular, diazotrophic cyanobacteria cyanothece. ESF-BU-CEBITEC Conference “Microorganoms for Bio-fuel Production from Sunlight” Bielefeld, Germany, September 18-21, 2011.

Carbon Storage and metabolic engineering of H2 production in the unicellular, diazotroph Cyanothece. 8th  European Workshop Molecular Biology of  Cyanobacteria, Naantali, Finland, August 28-September 1, 2011. 

Cyanothece, unicellular diazotophic cyanobacteria: physiology, genetics and modeling. Workshop on Cyanobacterial Metabolism: Models & Validation, Lake Geneva, WI, June 26-29, 2011. 

Regulations of Autotrophic and Heterothrophic Metabolism in Synechocystis sp. Strain PCC 6803 By HIK31 Operons on both the Chromosome and Plasmid   PSYSX. American Society for Microbiology Meeting, New Orleans, LA, May 21-24, 2011.

Publications
         Summerfield, T.C., Nagarajan, S. and Sherman, L.A.  2011.  Gene expression under low oxygen conditions and the role of the histidine kinase, Hik31 (Sll0790), in the cyanobacterium Synechocystis sp. PCC 6803.  Microbiology, 157:1-12.

McDermott, J.E. Oehmen, C., McCue, L.A., Hill, E., Choi, D., Stockel, J., Liberton, M., Pakrasi, H.B., and Sherman, L.A. 2011.  A model of cyclic tansciptomic behavior in the cyanobacterium Cyanothece sp. ATCC 51142.  Molecular BioSystems, 7:2407-2418.

Bandyopadhyay, A., Elvitigala, T. Welsh,E., Stöckel, J., Liberton,  M., Min, H. Sherman, L.A.,  and    Pakrasi, H.B.  2011. Novel   metabolic attributes of Cyanothece, a group of unicellular nitrogen fixing cyanobacteria. mBio 2:e00214-11.

Summerfield, TC, Toepel, J and Sherman, LA. 2011. Transcriptional Response to low O2 conditions in Synechocystis sp. Strain PCC 6803 includes induction of a gene cluster containing psbA and petC2Photosynthesis in the Global Perspective (Kadur, GN, editor), pp. 120-129.

Daniel Suter

Outside Activities
Invited Talk “The interplay between Src signaling and forces in adhesion-mediated neuronal growth cone migration”, Conway Institute of Biomolecular and Biomedical research, University College Dublin, Dublin, Ireland, May 6, 2011

Publications
Suter, D. M., and P. J. Hollenbeck. 2012. How to get on the right track. Nat. Neurosci. 15(1):7-8.

Snyder, J. E., O. Azizgolshani, B. Wu, Y. He, A. C. Lee, J. Jose, D. M. Suter, C. M. Knobler, W. M. Gelbart, and R. J. Kuhn. 2011. Rescue of infectious particles from pre-assembled alphavirus nucleocapsids cores. J. Virol. 85(12): 5773-81.

Suter, D. M., and K. E. Miller. 2011. The emerging role of forces in axonal elongation. Prog. Neurobiol. 94(2):91-101.

Suter, D. M. 2011. Live cell imaging of neuronal growth cone motility and guidance in vitro. Methods in Molecular Biology. In Cell Migration: Methods and Protocols, Second Edition, Claire Wells and Dr. Maddy Parsons (eds.) 769:65-86.

David H. Thompson

Outside Activities
Georgetown University, Department of Chemistry, 2/2/12.
Purdue University-Department of Biological Sciences, 11/16/11.
University of Michigan-Department of Chemistry, 11/10/11.
Technical University of Denmark, Department of Micro- and Nanotechnology, 8/11/11.

Recognitions
Alternate Councilor, American Chemical Society – Colloid & Surface Chemistry Division

Publications
A. Kulkarni, W. Deng, S.-H. Hyun, D. H. Thompson, 2012. “Development of a Safe and Effective pDNA Vector Based on Non-covalent Assembly of Bioresponsive Amino-b-Cyclodextrin:Adamantane-Poly(vinyl alcohol)-Poly(ethylene glycol) Transfection Complexes”, Bioconjugate Chemistry, in press.

A. Kulkarni, K. DeFrees, S.-H. Hyun, D. H. Thompson, 2012. “Pendant Polymer:Amino-b-Cyclodextrin:siRNA Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing”, Journal of the American Chemical Society, in press.

H.-k. Kim, H. Wei, A. Kulkarni, R. M. Pogranichniy, D. H. Thompson. 2012. “Effective Targeted Gene Delivery to Dendritic Cells via Synergistic Interaction of Mannosylated Lipid with DOPE and BCAT”, Biomacromolecules  (DOI: 10.1021/bm2014119).
W. Deng, J. Chen, A. Kulkarni, D. H. Thompson. 2012. “Poly(ethylene glycol)-Poly(vinyl alcohol)-Adamantanate: Synthesis and Stimuli-Responsive Micelle Properties”, Soft Matter  (DOI:10.1039/C2SM06394H).

A. Broniec, R. Klosinski, A. Pawlak, M. Wrona-Krol, D. H. Thompson, T. Sarna. 2011. “Interactions of Plasmalogens and Their Diacyl Analogs with Singlet Oxygen in Selected Model Systems”, Free Radical Biology & Medicine, 50, 892-898.

B. G. Coon, S. Crist, A. Gonzalez-Bonet, H.-k. Kim, J. Sowa, D. H. Thompson, T. L. Ratliff, R. C. Aguilar. 2011. “Fibronectin Attachment Protein (FAP) from Bacillus Calmette-Guerin as a Targeting Agent for Bladder Tumor Cells”, International Journal of Cancer (DOI: 10.1002/ijc.26413).

 

BARRY WANNER

Publications
Jung, S., Lee, M.-S., Kim, S.-K., and Wanner, B. L. 2012. Effect of Purine Limitation caused by an amidophosphoribosyl transferase (purF) mutation on polyphosphate kinase 1 (ppk1) gene expression. Genes & Genomics, in press

Tohsato, Y., Yamamoto, N., Nakayshiki, T., Takeuchi, R., WANNER, B. L., and Mori,H. 2011. Towards elucidation of the Escherichia coli K-12 unknowneome. Chapter 15 in Protein function prediction for Omics era, Ed: D. Kihara.

Semenova, E., Jore, M. M., Datsenko, K. A., Semenova, A., Westra, E. R., Wanner, B., Van der Oost, J., Brouns, S. J., and Severinov, K. 2011. Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence. Proc. Natl. Acad. Sci. U. S. A 108, 10098-10103. PM:21646539 PMC3121866

Vondenhoff, G. H., Blanchaert, B., Geboers, S., Kazakov, T., Datsenko, K. A., Wanner, B. L., Rozenski, J., Severinov, K., and Van, Van Aerschot, A. 2011. Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues. J. Bacteriol. 193, 3618-3623. PM:21602342 PMC3133342

OUTSIDE ACTIVITIES
“Towards development of Robust Optimized Cells (ROCs) for Experimentation and Modeling,” Institute of Molecular Medicine, National Cheng Kung University, Tainan, Taiwan, May 2012.

 “Mapping the Whole Escherichia coli K-12 transcriptome at single nucleotide resolution,” Mini-Symposium on Microbial Systems Biology, National Taiwan University, Taipei, Taiwan, April 2012.

 “The ROC Project: Towards development of Robust Optimized Chassis (ROCs) - platforms for development of efficient, safe, and secure biofactories,” National Defense Academy, Yokosuka-shi, Japan, January 2012.

“The ROC Project: Towards development of Robust Optimized Chassis (ROCs) - platforms for development of efficient, safe, and secure biofactories,” Institute for Advanced Biosciences, Keio Univ., Tsuruoka, Japan, January 2012.

“The ROC Project: Towards development of Robust Optimized Chassis (ROCs) - platforms for development of efficient, safe, and secure biofactories,” Nara Institute of Science and Technology (NAIST), Ikoma, Japan, January 2012.

“Towards Development of Robust Optimized Cells for Whole Cell Modeling and Making Biofactories,” Zing-IECA Conference on Enterobactericeae Gene Expression Profiling, Cancun, Mexico December 2011.

“Towards development of a robust simplified cell,” Synthetic Biology Workshop, Institute of Plant Physiology and Ecology, Key Laboratory for Synthetic Biology, Chinese Academy of Sciences, Shanghai, China, October 2011.

 “Towards development of a robust simplified cell,” Analytical Genetics (Carmona, Spain), October 2011.

Keynote speaker, “Mapping the whole Escherichia coli K-12 transcriptome at the single nucleotide level,” Society for General Microbiology Autumn Conference, University of York, England, UK, September 2011

“Towards development of a simplified cell,” Univ. Newcastle, Newcastle, UK, September 2011.

 “E. coli Genomics,” Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, August 2011.
 
“Towards Understanding the Unkowneome,” NAIST Microbial Workshop, Nara Institute of Science and Technology (NAIST), Ikoma, Japan, July 2011.

  “Evidence for cell-to-cell variation from Next Generation Sequencing of the E. coli K-12 transcriptome,” Conference on Stochastic Systems Biology, Monte Verita, Ascona, Switzerland July 2011.

 “Towards mapping whole bacterial transcriptomes at the single nucleotide level with E. coli K-12 as a test case,” Biotechnology Institute, Univ. Minn. June 2011.

Other Activities
Co-organizer, IECA 2013  Kenting, Taiwan, January 2013
Co-organizer, Zing-IECA Conference on Enterobactericeae Gene Expression Profiling, Cancun, Mexico, December 5-9, 2011

General Society of Microbiology Annual Conference, York, England UK, September 2011.

Stochastic Systems Biology meeting, Monte Verita, Switzerland July 2011

Molecular Microbiology Meeting, Institute for Molecular Infection Biology, Wuerzburg, Germany May 2011

American Society for Microbiology General Meeting. New Orleans, May 2011

Editor-in-Chief
Co-founder and co-Editor-in-Chief, BMC Microbial Informatics and Experimentation http://www.microbialinformaticsj.com/

Watts, Val
Chemel, B. R., Bonner, L. A., Watts, V. J., Nichols, D. E. 2012. Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D1 receptor catechol agoinsts. Mol. Pharm., In press.

Ejendal, K. F. K., Dessauer, C. W., Hebert, T. E., and Watts, V. J. 2012. Dopamine D2 receptor-mediated heterologous sensitization of AC5 requires signalosome assembly. J. Sig. Trans., In press.

Meyer, J. M., Ejendal, K. F.  K., Avramova. L., Garland-Kuntz, E., Giraldo-Calderón, G., Brust, T. F, Watts, V. J. and Hill, C. A. 2012. A “genome-to-lead” approach for insecticide discovery: pharmacological characterization and chemical compound screening of Aedes aegypti D1-like dopamine receptors. PLoS Neglected Trop. Diseases, 6: e1478.

McCorvy, J. D., Watts, V. J., and Nichols, D. E. 2012. Comparison of the D1 dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson’s disease. Psychopharmacology. Epub .

Cueva, J. P., Chemel, B. R., Juncosa, J. I., Lill, M. A., Watts, V. J., and Nichols, D. E. 2012. Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo­[a]phenanthridines. Eur. J. Med. Chem., 48: 97-107.

Clark, A. H., McCorvy, J. D., Watts, V. J., and Nichols, D.  E. 2011. Assessment of dopamine D(1) receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorg. Med. Chem., 19: 5420-5431.

Cueva, J. P., Gallardo-Godoy, A., Juncosa, J. I., Vidi, P. A., Lill, M. A., Watts, V. J., and Nichols, D. E. 2011. Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. J. Med. Chem., 54: 5508-5521.

Bonner, L. A., Laban, U., Chemel, B. R., Juncosa, J. I., Lill, M. A., Watts, V. J., and Nichols, D. E. 2011. Mapping the catechole binding site in dopamine D1 receptors: synthesis and evaluation of two parallel series of bicvclic dopamine analogs. Chem. Med. Chem., 6: 1024-1040.

Meyer, J. M., Ejendal, K. F., Watts, V. J., and Hill, C. A. 2011. Molecular and pharmacological characterization of two D(1)-like dopamine receptors in the Lyme disease vector, Ixodes scapularis. Insect Biochem. Mol. Biol., 41:6763-6770.

Vidi, P. A., Ejendal, K. F. K., Przybyla, J. A., and Watts, V. J. 2011. Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling. Mol. Cell. Endocrinol., 331:185-193.


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