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Psychological Sciences Faculty

Susan SanghaSusan Sangha

Assistant Professor, Behavioral Neuroscience

Mailing Address:
Department of Psychological Sciences
Purdue University
703 Third Street
West Lafayette, IN 47907-2081 USA

Campus Address:
Psychological Sciences, Room 3182

E-mail: sangha@purdue.edu
Telephone: (765) 494-0648
Website: www.sanghalab.com

Degree: Ph.D. University of Calgary, Canada, 2005

Research Interests:

Clinical disorders arising from maladaptive emotion regulation present a large burden on society worldwide. Many of these disorders show comorbidity, for example, addiction with anxiety disorders. Even though there has been much research on reward and fear processing, the majority of studies have been conducted in parallel, investigating the circuitries separately. If we hope to understand and treat comorbid disorders resulting from maladaptive emotion regulation we need to increase our efforts in investigating how these circuitries integrate their functions to influence behavior. This is the focus of the Sangha Lab. We have developed a novel behavioral paradigm explicitly designed to assess reward, fear and safety cue learning together in order to investigate the multiple circuitries that regulate these learning processes. Using a combination of behavioral, electrophysiological and pharmacological techniques, we track biological changes in the rat brain as it is learning about reward, fear, and safety signals.

Representative Publications:

Sangha S, Ilenseer J, Sosulina L, Lesting J, Pape H-C (2012). Differential regulation of glutamic acid decarboxylase gene expression after extinction of a recent memory versus intermediate memory. Learning & Memory, 19:194-200.

Christianson JP, Fernando ABP, Kazama AM, Jovanovic T, Ostroff LE, Sangha S (2012). Inhibition of fear by learned safety signals: minisymposium review. Journal of Neuroscience, 32(41): 14118-14124.

Sangha S, Chadick JZ, Janak PH (2013). Safety encoding in the basal amygdala. Journal of Neuroscience, 33: 3744-3751.

Sangha S, Robinson PD, Davies DA, Greba Q, Howland JG (2014). Alterations in reward, fear and safety cue discrimination after inactivation of the prelimbic and infralimbic cortices. Neuropsychopharmacology, 39:2405-2413.

Sangha S*, Greba Q, Robinson PD, Ballendine SA, Howland JG* (2014). Normal fear and safety cue discrimination but alterations in fear regulation after extinction in an animal model of schizophrenia. Front Behav Neurosci, 8: 168.