Tara M. Henagan


Assistant Professor
Department of Nutrition Science (NUTR)

Contact Information

Office STON G1G
Address 700 W. State Street
West Lafayette, IN 47907
Phone 765.494.4536
Fax 765.494.0906
E-Mail thenagan@purdue.edu

Links

Educational Background

  • BS, Biological Sciences at Louisiana State University in 2004
  • PhD, Minor, Pathobiological Science at Louisiana State University in 2010
  • PhD, Exercise Physiology at Louisiana State University in 2010
  • T32 Postdoctoral Fellow, Neurosignaling/Preventative Medicine at Pennington Biomedical Research Center in 2013

Certificates & Licenses

  • NSCA Strength and Conditioning Specialist - Certified in creating and implementing resistance training programs in 2010

Awards & Honors

  • Adjunct Assistant Professor from Pennington Biomedical Research Center, 2013 - Present

Activities & Memberships

  • (Member), American College of Sports Medicine - Present
  • (Member), American Physiological Society - Present
  • (Advisor), Purdue CHAARG - Present

Discovery

Nutrition and exercise interventions have the potential to attenuate the development of insulin resistance, decrease chronic inflammation and reduce the risk of developing cardiovascular disease risk and metabolic syndrome. Our laboratory is interested in continuing to develop research lines to elucidate mechanisms whereby various nutritional and exercise interventions alter the chromatin state and crosstalk between nuclear and mitochondrial compartments, essentially epigenetically programming mitochondrial adaptation in lean, insulin sensitive or obese, insulin resistant states. We are currently utilizing both clinical and cellular models to determine 1) the effects of dietary fat and/or exercise training on the chromatin state within skeletal muscle that results in differential cellular phenotypes, metabolomes (acylcarnitine profiles) and whole body energy expenditures and phenotypes, focusing on nucleosome reorganization; and 2) epigenetic regulation of PGC1a in skeletal muscle by supplementation with the botanical extract, quercetin, or the metabolite produced by dietary fiber fermentation, butyrate. Understanding the epigenetic mechanisms whereby nutrition and physical activity regulate nuclear gene expression and coordinate with downstream mitochondrial gene expression to determine mitochondrial number and function is crucial in understanding, treating and preventing obesity and type 2 diabetes.

Discovery Publications

  • Henagan TM, Lenard NR, Gettys TW, Stewart LK. (2014) Dietary quercetin supplementation in mice increases skeletal muscle PGC1α expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS One. 9(2):e89365. doi: 10.1371/journal.pone.0089365.
  • Laeger T, Reed SD, Henagan TM, Fernandez DH, Tagahavi M, Addington A, Munzberg H, Martin RJ, Hutson SM, Morrison CD. (2014) Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein.. Am J Physiol Regul Integr Comp Physiol. ajpregu.00116.2014.
  • Laeger T, Henagan TM, Albarado DC, Redman LM, Bray GA, Noland RC, Münzberg H, Hutson SM, Gettys TW, Schwartz MW, Morrison CD. (2014) FGF21 is an endocrine signal of protein restriction. Journal of Clinical Investigation. 124(9):3913-22. doi: 10.1172/JCI74915.
  • Erin M Taylor, Aarin D Jones and Tara M Henagan. (2014) Mitochondrial-derived Fatty Acids in Epigenetic Regulation of Obesity and Type 2 Diabetes. Journal of Nutritional Health & Food Science. 2(3):1-4.
  • Forney, L., Earnest, C.P., Henagan, T.M., Johnson, L., Castleberry, T., and Stewart, L.K. (2013) Vitamin D status, body composition and fitness measures in younger, physically active individuals. Journal of Strength and Conditioning Research.:Pages. ISSN 1064-8011.
  • Tchoukalova, Y.D., Fitch, M., Rogers, P.M., Covington, J.D., Henagan, T.M., Hellerstein, M.C., Ye, J. and Ravussin, E. (2012) In vivo adipogenesis in rats measured by cell kinetics in adipocytes and plastic-adherent stroma-vascular cells in response to high fat diet and thiazolidinedione. Diabetes. 61(1):137-44. PMID: 2212446.
  • Morrison, C.D., Reed, S., Henagan, T.M. (2012) Homeostatic regulation of protein intake: In search of a mechanism. Am J Physiol Integr Comp Physiol.:Pages. doi:10.1152/ajpregu.00609.2011. PMID: 22319049.
  • Henagan T.M., Forney, L., Dietrich, M.A., Harrell, B.R., and Stewart, L.K. (2012) Melanocortin receptor expression is associated with reduced CRP in response to resistance training. Journal of Applied Physiology.:Pages. doi:10.1152/japplphysiol.00107.2012. PMID: 22678961.
  • Zhang, J., Henagan, T.M., Gao, Z., Ye, J. (2011) Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. Endocrinology. 152(5):1829-38. Other Information.
  • Henagan, T.M., Philips, M., Cheek, D., Kirk, M., Barbee, J.J., and Stewart, L.K. (2011) Melanocortin 3 receptor: A novel mediator of exercise-induced inflammation reduction in postmenopausal women?. Journal of Aging Research.:Pages. Jan 2011: 512593.
  • Hasek, B.E., Stewart, L.K., Henagan, T.M., Lenard, N.R., Boudreau, A., Black, C., Shin, J., Huypens, P., Malloy, V., Plaisance, E., Krajcik, R.A., Orenteich, N., and Gettys, T.W. (2010) Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. Am J Physiol Integr Comp Physiol. 299(3):R728-39. Other Information.
  • Plaisance, E., Henagan, T.M., Echlin, H., Boudreau, A., Hill, K.R., Lenard, N.R., Hasek, B.E., Orentreich, N., Gettys, T.W. (2010) Role of β-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction: Companion Paper. Am J Physiol Intgr Comp Physiol. 299(3):R740-50. Other Information.
  • Zhang, Y., Huypens, P., Adamson, A.W., Chang, J., Henagan, T.M. Boudreau, A., Lenard, N.R., Burk, D., Klein, J., Perwitz, N., Shin, J., Fasshauer, M., Kralli, A., and Gettys, T.W. (2009) Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1α. Journal of Biological Chemistry. 284(47):32813-26. Other Information.

Books, Chapters & Monograph Publications

  • Muenzberg, H., Henagan, T.M., and Gettys, T.W. (In Press) Animal Models of Obesity. In: Handbook of Obesity, 3rd Edition. George A. Bray and Claude Bouchard (eds) Ed(s). Pp.Pages. Publisher, City, State/Country. Other Information.
  • Henagan, T.M., Daray, L.A. and Stewart, L.K. (2009) The Role of Exercise in Modulating Circulating Concentrations of C-Reactive Protein: A Critical Review. In: C-Reactive Protein: New Research. S. Nagasawa (ed) Ed(s). Ch.Chapters. Pp.Pages. Publisher, City, State/Country. Other Information.

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