Silvia Stan

Educational Background

  • Ph.D., Food Science and Technology/Biochemistry and Biophysics (minor) at Oregon State University in 2004

Awards & Honors

  • Editorial Board Member of Cancer Prevention Research, 2009 - Present
  • Teaching for Tomorrow Award, from Purdue University, 2016

Activities & Memberships

  • Member, American Association for Cancer Research
  • Member, American Society for Nutrition
  • Member, Institute of Food Technologists


Stan Lab research interests and expertise are in cancer prevention with diet-derived bioactive compounds. We investigate the cancer preventive activity of several diet-derived bioactive compounds (e.g., isothiocyanates and organosulfur compounds), and work to understand their mechanisms of action by identifying key molecular targets. Current research focuses primarily on pancreatic and breast cancer chemoprevention, and targets both prevention of early stages of carcinogenesis (primary, secondary prevention) and recurrence. 

Discovery Publications

  • Kiesel V.A., Stan S.D.* Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells. Biochemical and Biophysical Research Communications 2017 484(4): 833-838. (*, PI and corresponding author)
  • Stan S.D.*, Singh S.V., Whitcomb D.C., and Brand R.E. Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model. Nutrition and Cancer, 2014 66(4): 747-755.
  • Stan, S.D.*, Singh, S.V., and Brand, R.E. Chemoprevention strategies for pancreatic cancer. Nature Reviews Gastroenterology and Hepatology, 2010 7(6): 347-356.
  • Stan, S.D. and Singh, S.V. Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells. Clinical Cancer Research, 2009 15(15):4895-4903.
  • Singh, S.V., Warin, R., Xiao, D., Powolny, A.A., Stan, S.D., Arlotti, J.A., Zeng, Y., Hahm, E.R., Marynowski, S.W., Bommareddy, A., Desai, D., Amin, S., Parise, R.A., Beumer, J.H., and Chambers, W.H. Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Research, 2009 69(5): 2117-2125.
  • Stan, S.D., Zeng, Y., and Singh, S.V. Ayurvedic medicine constituent withaferin A causes G2 and M phase cell cycle arrest in human breast cancer cells. Nutrition and Cancer, 2008 60: 51-606.
  • Stan, S.D., Hahm, E.R., Warin, R., and Singh, S.V. Withaferin A causes FOXO3a- and Bim- dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Research, 2008 68(18): 7661-7669.
  • Singh, S.V., Powolny, A.A., Stan, S.D., Xiao, D., Arlotti, J.A., Warin, R., Hahm, E.R., Marynowski, S.W., Bommareddy, Potter, D.M., and Dhir, R. Garlic constituent diallyl trisulfide prevents development of poorly-differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice. Cancer Research, 2008 68(22): 9503-9511.
  • Stan, S.D., Kar, S., Stoner, G.D., and Singh, S.V. Bioactive food components and cancer risk reduction. Journal of Cellular Biochemistry, 2008 104(1): 339-356.
  • Herman-Antosiewicz, A., Stan, S.D., Hahm, E.R., Xiao, D., and Singh, S.V. Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1-dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive constituent of processed garlic. Molecular Cancer Therapeutics, 2007 6(4): 1249-1261.


NUTR 20200 Principles of Food Preparation and Nutrition. This course covers principles of food preparation (chemical, physical and microbiological aspects) and nutrition (functions and sources of nutrients, and their relationship to a healthy lifestyle). Dr. Stan teaches the nutrition part of the course.
NUTR 31500 Fundamentals of Nutrition. This is a nutrition survey core course for undergraduate nutrition majors.
NUTR 63400 Nutrition and Cancer Prevention. This is a graduate-level course that offers an in-depth examination of the role of nutrition in cancer prevention. 
NUTR 69500 Interdepartmental Nutrition Program (INP) Graduate Seminar

Silvia Stan

Assistant Professor

Office: STON G1D
Phone: 765.494.9417
Fax: 765.494.0906

Department of Nutrition Science, 700 W. State Street, West Lafayette, IN 47907-2059(765) 494-8228, Fax: (765) 494-0674

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