Elsa Janle

Educational Background

  • B.S., Chemistry at Ursinus College in 1963
  • M.S., Organic Chemistry at Purdue University in 1965
  • Ph.D., Physiology at Purdue University in 1980
  • Post-Doc., Insulin Receptors at Indiana University School of Medicine in 1982

Dissertation Title

Experimental Diabetes in Dogs: I. Effects of Pancreatic Tissue Implants, II. Plasma Osmolality Following Glucose Infusion

Awards & Honors

  • Space Act Award from NASA, 2000

Activities & Memberships

  • American Diabetes Association
  • American Chemical Society
  • Sigma Xi
  • American Society for Nutrition

Discovery

My major interest is diabetes and glucose control. To monitor glucose in diabetics without removal of blood, I developed the ultrafiltrate probe. The ultrafiltrate probe is a membrane probe which can be implanted in subcutaneous tissue. A negative pressure is applied and interstitial fluid is removed. These probes can be used for long term monitoring in large or small animal models. I have also worked on additional uses of the ulrafiltrate probe for other areas of medical research including measurement of bone minerals in bone, muscle and subcutaneous tissue. In the area of botanicals, I am investigating the potential of green tea and other supplements to improve glucose tolerance and reduce long term complications of diabetes.

As a member of the Botanical Center for Age Related Diseases, I work with other investigators in the centers to study the bioavailabiliy, metabolism and tissue distribution of botanical compouds in animal models. A major focus of this investigation is the determination of the potential of bioactives and metabolites to cross the blood brain barrier, with the ultimate goal of finding supplements which might prevent neurodegeneration in the elderly or improve brain development and learning in the young.
Another project involves the determination of berries to prevent osteoporosis.

Discovery Publications

  • Scott, D., Willis, S., Gabber, S., Johnson, D., Naylor, E., Janle, E., Kritchevsky, J., Lunte, C., Lunte S. (2015) Development of an on-animal separation based senior for monitoring drug metabolism in freely roaming sheep. Analyst. DOI: 10.1039/C4AN01928H.
  • Wand, D., Ho, L., Faith, J., Ono, K., Janle, E.M., Lachick, P.J., Cooper, B.R., Jannasch, A.H., D'Arcy, B.R., Williams, B.A., Ferruzzi, M.G., Levine, S., Zhao, W., Dubner, L., Pasinetti, G.M. (2015) Role of intestinal microbiota in the generation of polyphenol derived phenolic acid mediated attenuation of Alzheimer's disease B-amyloid oligomerization. Mol Nutr Food Res. Feb 17. doi: 10.1002/mnfr.201400544.
  • Wang, J., Bi, W., Cheng, A., Freire, D., Vempati, P., Zhao, W., Gong, B., Janle, E., Chen, T-Y., Ferruzzi, M., Schmeidler, J.S., Ho, L., Pasinetti, G.M. (2014) Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer’s disease: Experimental approach and therapeutic implications. Frontiers in Neuroscience. 6:1-10. March 2014; DOI 10.3389.
  • Janle, E.M., Freiser, H., Manganais, C., Chen, T-Y., Craig, B.A., Santerre, C.R. (2014) Green Tea Increases the Concentration of Total Mercury in the Blood of Rats Following an Oral Fish Bolus. Biomed Research International. Article ID 320936. http://dx.doi.org/10.1155/2014/320936.
  • Zhang S, Myracle A, Xiao K, Yan P, Ye T, Mario Ferruzz M, Janle EM, Raftery D. (2013) Metabolic Profiling of Green Tea Treatments in Zucker Diabetic Rats Using 1H NMR. Journal of Nutrition and Food Science . 3(6):239. doi: 10.4172/2155-9600.1000239.
  • Wang J, Tang C, Ferruzzi MG, Gong B, Song BJ, Janle EM, Chen T-Y, Cooper B, Varghese M, Cheng A, Freire D, Roman J, Nguyen T, Ho L, Talcott ST,. Simon E, Wu Q, Pasinetti GM. (2013) Role of Standardized Grape Polyphenol Preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome. Mol Nutr Food Res . 57:2091-102.
  • Ho, L., Ferruzzi, M.G., Janle, E.M., Wang, J., Gong, B., Chen, T.-Y., Lobo, J., Cooper, B., Wu, Q.-L., Talcott, S.T., Percival, S.S., Simon, J., and Pasinetti, G.M. (2013) Identification of Brain-targeted Bioactive Dietary Quercetin 3-O-GlucuronideAs A Novel Intervention for Alzheimer's Disease. FASEB Journal.
  • Lila, M., Ribnicky, D., Rojo, L., Rojas-Silva, P., Oren, A., Janle, E., Raskin, I., Yousef, G., and Grace, M. (2012) Complementary approaches to gauge the bioavailability and distribution of ingested berry polyphenolics. J Agric Food Chem. 20(23):5763-5771.
  • Wang, J., Ferruzzi, M.G., Ho, L., Blount, J., Janle, E., Gong, B., Pan, Y., Raftery, D., Arrieta-Cruz, I., Sharma, V., Cooper, B., Lobo, J., Simon, J., Cheng, A., Qian, X., Zhang, C., Ono, K., Teplow, D., Pavlides, C., Dixon, R., and Pasinetti, G. (2012) Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment. J Neuroscience. 32:5144-5150.
  • Weinheimer, E.M., Conley, T.B., Kobza, V.M., Sands, L.P., Lim, E., Janle, E.M., and Campbell, W.W. (2012) No affect of whey protein supplementation on exercise training-induced changes in body composition and indices of metabolix syndrom in middle-aged overweight and obese adults. J Nutr. 142(8):1532-9.
  • Madian, A.G., Myracle, A., Diaz-Maldonado, N., Janle, E., and Regnier, F.E. (2011) Determining the effects of antioxidants on oxidative stress induced post-translational modifications of proteins. Analytical Chemistry. 83(24):9328-9336.
  • Madian, A.G., Myracle, A., Diaz-Maldonado, N., Janle, E., and Regnier, F.E. (2011) Differential Carbonylation of Proteins as a Function of in vivo Oxidative Stress. J Proteome Research. 10(9):3959-3972.
  • Barnes, S., Prasain, J., D'Alessandro, T., Arabshahi, A., Botting, N., Lila, M.A., Jackson, G., Janle, E.M., and Weaver, C.M. (2011) The metabolism, distribution and analysis of dietary polyphenols in foods and biological systems. Foods & Function . www.rsc.org/foodfunction.
  • Vingtdeux, V., Zhao, H., Chandakkar, P., Wu, C., Simon, J.E., Janle, E., Lobo, J., Ferruzzi, M.G., Davies, P., and Marambaud. (2010) AMPK-activated protein kinase signaling activation by resveratrol modulates amyloid-a peptide metabolism. Journal of Biological Chemistry. 285:9100-9113.
  • Janle, E., Lila, M.A., Wood, L., Higgins, A., Yousef, G.G., Rogers, R.B., Kim, H., Jackson, G.S., Ho, L., and Weaver, C. (2010) Method for evaluating the potential of 14C labeled plant polyphenols to cross the blood-brain barrier using accelerator mass spectrometry. Nuclear Instruments and Methods in Physics Research, section B, Beam Interaction with Materials and Atoms (NIMB). 268(7):1313-1316.
  • Neilson, A.P., Sapper, T.N., Janle, E.M., Rudolph, R., Matusheski, N.V., and Ferruzzi, M.G. (2010) Chocolate matrix factors modulate the pharmacokinetic behavior of cocoa flavan-3-ol phase II metabolites following oral consumption by Sprague-Dawley rats. J Agric Food Chem. 58:6685-6691.
  • Mun, J.G., Grannan, M.D., Lachcik, P.J., Rogers, R.B., Yousef, G.G., Grace, M.H., Janle, E.M., Wu, Q.L., Simon, J.E., Weaver, C.M., and Lila, M.A. (2010) Tracking deposition of a 14C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone. Experimental Medicine and Biology. 235:1224-1235.
  • Peters, C.M., Green, R.J., Janle, E.M., and Ferruzzi, M.G. (2010) Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea. Food Research International. 43:95-102.
  • Janle, E.M., Lila, M.A., Grannan, M., Wood, L., Higgins, A., Yousef, G.G., Rogers, R.B., Kim, H., Jackson, G.S., Ho, L., and Weaver, C.M. (2010) Pharmacokinetics and Tissue Distribution of 14C Labeled Grape Polyphenols in the Periphery and the Central Nervous System Following Oral Administration. Journal of Medicinal Food. 13(4):926-933.
  • Ferruzzi, M.G., Lobo, J.K., Janle, E., Cooper, B., Simon, J.E., Wu, Q-L., Welch, C., Ho, L., Weaver, C., and Pasinetti, G.M. (2009) Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment of Alzheimer's Disease. Journal of Alzheimer's Disease. 18:113-24.
  • Ferruzzi, M.G., Lobo, J.K., Janle, E., Whittaker, N., Cooper, B., Simon, J.E., Wu, Q-L., Welch, C., Ho, L., Weaver, C. and Pasinetti, G.M. (2009) Bioavailability of gallic acid and catechins from neuroprotective grape seed extract is improved by repeated dosing in rats. Journal of Alzheimer's Disease. 18(1):113-24.
  • Weaver, C.M., Janle, E., Martin, B.R., Browne, S., Guiden, H., and Lachcik, P. (2009) Dairy vs. Calcium Carbonate in Promoting Peak Bone Mass and Bone Maintenance During Subsequent Calcium Deficiency. JBMR. 24:1411-19.
  • Neilson, A.P., George, J.C., Janle, E.M., Mattes, R.D., Rudolph, R., Matusheski, N.V., and Ferruzzi, M.G. (2009) Influence of food matrix on cocoa flavan-3-ol bioaccessibility in vitro and bioavailability in humans. Journal of Agriculture and Food Chemistry. 57:9418-9426.
  • Ho, L., Chen, L.H., Wang, J., Zhao, W., Talcott, S.T., Ono, K., Teplow, D., Humala, N., Cheng, A., Percival, S.S., Ferruzzi, M.G., Janle, E., Weaver, C., Dickstein, D.A., and Pasinetti, G. (2009) Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. Journal of Alzheimer's Disease. 16:59-72.
  • Shim, S.M., Ferruzzi, M., Kim, Y.C., Janle, E.M., and Santerre, C.R. (2009) Impact of phytochemical-rich foods on bioaccessibility of mercury from fish. Food Chemistry. 112:46-50.
  • Weaver, C., Barnes, S., Wyss, J.M., Kim, H., Morre, D., Morre, J., Simon, J., Lela, M.A., Janle, E., and Ferruzzi, M. (2009) Research Highlights from the Purdue-UAB Botanicals Research Center for Age Related Diseases. Pharmaceutical Biology. 47:768-773.
  • Janle, E.M., Morré, D.M., Morré, D.J., Zhou, Q., Zhu, Y. (2008) Pharmacokinetics of Green Tea Catechins in Extract and Sustained Release Preparations. Journal of Dietary Supplements. 5:248-63. Doi: 10.1080/19390210802414279. PMCID: PMC2747776. http://www.pubmedcentral.gov/articlerender.fcgi?artid=2747776.
  • Janle, E., Sojka, J., Jackson, G.S., Lachcik, P., Einstien, J.A., and Santerre, C.R. (2007) Measuring transfer of 14C-PCB from maternal diet to milk in a goat model using an accelerator mass spectrometer (AMS). Nuclear Instruments and Methods in Physics Research, section B.:758-762.

Books, Chapters & Monograph Publications

  • Madian, A.G., Janle, E.M., Regnier, F.E. (2013): Examination of the efficacy of antioxidant food supplements using advanced proteomics methods. In: Foodomics, Alejandro Cifuentes Ed(s). Ch.4 Pp.101-124. John Wiley & Sons, Hoboken, New Jesery.
  • Janle, E.M. and Kissinger, P.T. (1996) Microdialysis and Ultrafiltration in Advances in Nutrition. Academic Press. 40:183-196.
  • Janle-Swain, E. (1985) Animal Models of Diabetic Nephropathy. In: Handbook of Animal Models for Renal Failure. Ash, S.R. and Thornhill, J.A Ed(s). CRC Press, Boca Raton, FL.

Elsa Janle

Associate Research Professor

Office: STON G37
Phone: 765.494.1566
Fax: 765.494.0906
E-Mail: janle@purdue.edu

Department of Nutrition Science, 700 W. State Street, West Lafayette, IN 47907-2059(765) 494-8228, Fax: (765) 494-0674

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