Emir Uzay, PhD

Research Interests/Training Areas

  • Studying the neurochemical basis of brain plasticity:
  • Developing methods for profiling psychiatric disorders and psychoactive drug discovery
  • Neurochemical profiling of brain cancer
  • Unraveling the neurochemical mechanism of BOLD-fMRI signal

Biography

Dr. Uzay E Emir is currently an Assistant Professor in the School of Health Sciences at Purdue University.  Having received his PhD degree from Bogazici University, Turkey, in which he studied BOLD fMRI signal transients with different neuro imaging modalities, he broadened his scientific expertise further by undertaking postdoctoral training in the field of ultra high field (UHF) magnetic resonance spectroscopy (MRS) methods. Following this extensive training period, he worked at the FMRIB Centre, University of Oxford, from 2013-2017 as a Head of Magnetic Resonance Spectroscopy. Dr. Emir’s expertise lies in the development and clinical translation of magnetic resonance spectroscopy (MRS) techniques at clinical (3T) and ultra-high field (UHF>3T) magnetic fields. He have used these systems at both 3T and 7T to quantify various brain metabolites, including neurotransmitters (γ-amino butyric acid, GABA, and glutamate, Glu) in Parkinson’s Disease (PD); antioxidants (glutathione, GSH, and ascorbate, Asc) in aging; and oncometabolites (2 hydroxyglutarate, 2-HG, and lactate, Lac) in patients with glioma.

Recent Publications

Ip B, Berrington A, Parker A, Hess A, Emir UE, Bridge H (2017) Combined fMRI-MRS acquires simultaneous glutamate and BOLD-fMRI signals in the human brain. Neuroimage 155, 113-119.

Emir UE, Burns B, Jezzard P, Thomas A (2017), Metabolite-Cycling Short-Echo Time Magnetic Resonance Spectroscopic Imaging using a Concentric Ring k-space Trajectory NMR Biomed 30:e3714.

Emir UE, Larkin SJ, de Pennington N, Voets N, Plaha P, Stacey R, Al-Qahtani K, McCullagh J, Schofield CJ, Clare S, Jezzard P, Cadoux-Hudson T, Ansorge O (2016) Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations. Cancer Res 76:43-49.

Lunghi C, Emir UE, Morrone MC, Bridge H (2015) Short-term monocular deprivation alters GABA in the adult human visual cortex. Curr Biol 25:1496-1501.

Emir UE, Raatz S, McPherson S, Hodges JS, Torkelson C, Tawfik P, White T, Terpstra M (2011) Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain. NMR Biomed 24:888-894.

Emir UE, Tuite PJ, Oz G (2012) Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 tesla proton MRS. PLoS One 7:e30918.

Emir UE, Auerbach EJ, Van De Moortele PF, Marjanska M, Ugurbil K, Terpstra M, Tkac I, Oz G (2012) Regional neurochemical profiles in the human brain measured by (1)H MRS at 7 T using local B(1) shimming. NMR Biomed 25:152-160.

Emir UE, Raatz S, McPherson S, Hodges JS, Torkelson C, Tawfik P, White T, Terpstra M (2011) Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain. NMR Biomed 24:888-894.

Uzay Emir
Assistant Professor

Phone: 765-496-0514
Fax: 765-496-1377
E-mail:  uemir@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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