Keith M. Stantz, Ph.D.

Research Interests / Training Areas

  • Physiological Imaging using Dynamic Contrast-Enhance Imaging
    • Quantify intra-tumor physiology
    • Influence of tumor angiogenic phenotype in cancer progression
    • Investigate intra-tumor hemodynamic response to anti-angiogenic therapies
  • Development of Thermoacoustic CT Imaging
    • Molecular Imaging using Photoacoustic CT-spectroscopy (PCT-S)
    • Particle Beam Dosimetric Imaging using Radiation-induced Acoustic CT (RACT)
  • Modeling and Tumor Biology
    • Mathematical models to fuse in vivo mulit-parametric measurements of tumor hemodynamics
    • Explore influence of hypoxia on cancer stem cell prevalence
    • Investigate influence of anti-angiogenic and radiation therapy on CSCs and inflammatory processes

Biography

Dr. Keith Stantz is a Professor of Imaging Sciences and Medical Physics within the School of Health Sciences at Purdue University. Dr. Stantz obtained a B.S. degree from Valparaiso University in ECE and Physics (1988); an M.S. degree in Physics from Michigan State University (East Lansing, MI); and a PhD from Indiana University (Bloomington, IN) in particle physics, where he was part of the MEGA research team investigating rare muon decay at Los Alamos National Laboratory. As a Project and Research Scientist at two small companies and IUSM, he developed CT, optical and thermoacoustic imaging instrumentation and methods. As a faculty at Purdue, his research continues to focus on developing diagnostic imaging in the treatment of cancer, and the training of students in the Medical Physics and the field of Imaging Sciences.

Recent / RepresentativePublications

Stantz K, Alsanea F, Moskvin V. Feasibility of RACT for 3D dose measurement and range verification in a water phantom. Med Phys 42(2):937-946, 2015.

Cao N, Cao M, Chin-Sinex H, Mendonca M, Ko S-C, Stantz KM. Monitoring the Effects of Anti-angiogenesis on the Radiation Sensitivity of Pancreatic Cancer Xenografts Using Dynamic Contrast-Enhanced CT. Int J of Radiat Oncol Biol Phys88(2):412-8, 2014.

Choi M-R, Bardhan R, Stanton-Maxey KJ, Badve S, Nakashatri H, Stantz KM, Cao N, Halas NJ, Clare SE, Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan Horse. Cancer Nanotechnology 3: 47-54, 2012.

Stantz KM, Cao M, Liang Y, Miller KD. Monitoring the Longitudinal Intra-Tumor Physiology Impulse Response to VEGFR2 Blockade in Breast Tumors Using DCE-CT. Molecular Imaging and Biology3(6):1183-95, 2011.

Stantz KM. Imaging hypoxia using 3D photoacoustic spectroscopy, Proc SPIE BIOS7564: 7564419-7564419-6, 2010.

Cao M, Liang Y, Stantz K. Response Letter: Developing DCE-CT to Quantify Intra-Tumor Heterogeneity in Breast Tumors with Differing Angiogenic Phenotypes. IEEE Trans Med Imaging29(4):1089-1092, 2010.

Stantz KM, Cao N, Liu B, Cao M, Chin-Sinex H, Mendonca M, Li JJ. Effects of Radiation on tumor hemodynamics and NF-kappaB in breast tumors. Proc SPIE BIOS7564: 75641J-75641J-6, 2010.

Cao M, Liang Y, Miller K, Stantz KM. Developing DCE-CT to Quantify Intra-Tumor Heterogeneity in Breast Tumors with Differing Angiogenic Phenotypes. IEEE Trans. Med. Imaging28(6):861-871, 2009.

Liu B, Reinecke D, Kruger RA, Stantz KM. Phantom and In Vivo Measurements of Hemoglobin Concentration and Oxygen Saturation Using PCT-S Small Animal Scanner. Proc SPIE BiOS6437:64371X1-9, 2007.

Stantz KM, Liu B, Cao M, Reinecke D, Miller K, Kruger R. Photoacoustic spectroscopic imaging of intra-tumor heterogeneity and molecular identification, Proc. SPIE BIOS 6086:36-47, 2006.

Curriculum Vitae

Click here for a full CV for Keith M. Stantz. (an Adobe Acrobat file)

Keith M. Stantz

Associate Professor of Health Sciences
Assistant Professor of Radiology, Indiana University School of Medicine

Phone: 765-496-1874
Fax: 765-496-1377
E-mail: kstantz@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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