Jonathan Shannahan, Ph.D.

Research Interests/Training Areas

  • Susceptible Subpopulation to Toxic Insults
  • Role of the Nanoparticle-Biocorona in Cellular Interactions
  • Responses of the Immune System to Engineered Nanomaterials
  • Omics Approaches

Biography

Jonathan Shannahan is an Assistant Professor in the School of Health Sciences at Purdue University in West Lafayette, IN.  He received his B.S. in Chemistry from North Carolina State University and a Ph.D. in Toxicology from the University of North Carolina Chapel Hill.  He did his post-doctoral work at East Carolina University and the University of Colorado Anschutz Medical Campus.   The Shannahan laboratory mechanistically investigates toxicity associated with environmental and occupational exposures utilizing both in vitro and in vivo models.  His research team is especially interested in understanding how individuals with underlying diseases such as cardiovascular disease respond to exposures. These studies evaluate immune, cardiovascular, and pulmonary toxicity associated with engineered nanomaterial exposures.  Specifically examining the role of surface associated physiological macromolecules, and how their addition alters nanomaterial cellular interactions, immune responses, and disease progression.  Overall the goal of these studies are to 1) elucidate mechanisms of toxicity in susceptible subpopulations in order to mitigate adverse public health effects; 2) determine physicochemical properties of engineered nanomaterials related to toxicity allowing for their safe and effective usage; 3) utilize novel and emerging technologies to assess mechanisms of toxicity.

Recent Publications

Shannahan J., Fritz K., Raghavendra A., Podila R., and Brown J. Disease-induced disparities in formation of the nanoparticle-biocorona and the toxicological consequences. Tox. Sci. 2016

Mallineni S., Shannahan J., Raghavendra A., Rao A., Brown J., and Podila R. Biomolecular interactions and biological responses of emerging two-dimensional materials and aromatic amino acid complexes. ACS Appl. Mater Interfaces 2016

Shannahan J., Podila R., and Brown, J.M. A hyperspectral and toxicological analysis of protein corona impact on silver nanoparticle properties, intracellular modifications and macrophage activation. Inter. J. Nanomedicine. 2015

Shannahan J., Sowrirajan H., Persaud I., Podila R., and Brown J.  Impact of Silver and Iron Nanoparticle Exposure on Cholesterol Uptake by Macrophage. J. of Nanomaterials. 2015

Aldossari, A.,* Shannahan, J.,* Podila, R., and Brown, J. (*Authors contributed equally). Influence of physicochemical properties of silver nanoparticles on mast cell activation and degranulation. In Vitro Tox. 2015

Shannahan, J., Podila, R., Aldossari, A., Emerson, A., Powell, B., Ke, P., Rao, A., and Brown, J. (2014). Formation of a protein corona on silver nanoparticles mediates cellular toxicity via scavenger receptors. Tox. Sci. 2014

Complete List of Published Work: https://scholar.google.com/citations?hl=en&user=eI5DPDkAAAAJ

Lab News

High school sophomore studies nanoparticles at college lab

Dr. Jonathan Shannahan
Assistant Professor of Health Sciences and Toxicology

Phone:  765-494-2326
Fax: 765-496-1377
E-mail: jshannah@purdue.edu

Purdue University, School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, (765) 494-1419, Fax: (765) 496-1377

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