Jennifer Freeman, Ph.D.
Freeman Laboratory Research Video Link: https://www.youtube.com/watch?v=lz0fDBGEVc
Research Interests / Training Areas
- Environmental and molecular toxicology
- Developmental origin of health and disease
- Genome and epigenome alterations
- Molecular cytogenetics
- Zebrafish model system
Jennifer L. Freeman is an Associate Professor in the School of Health Sciences at Purdue University in West Lafayette, IN. She received a B.S. in Cell and Structural Biology from the University of Illinois at Urbana-Champaign and a Ph.D. in Environmental Toxicology and Molecular Cytogenetics from the University of Illinois at Urbana-Champaign. She did her post-doctoral work at Harvard Medical School and Brigham and Women’s Hospital, Boston. The interests of the Freeman laboratory are to define the underlying genetic and epigenetic mechanisms of toxicity of environmental stressors with current focus on pesticides, metals, radiation, and emerging contaminants. Projects are defining the immediate adverse impacts of a developmental exposure, the lasting adverse impacts of this developmental exposure throughout the lifespan, and the analysis of subsequent generations linking genetic, epigenetic, and phenotypic assessments. These studies are investigating the developmental origin of health and disease pathogenesis with a specific focus on neurological disorders, reproductive dysfunction, cardiovascular function, and cancer with a goal of understanding the role of exposure to the environmental stressors in these adverse health outcomes. All projects are currently utilizing the zebrafish vertebrate model system as a tool to investigate toxicity.
Wirbisky, S., G.J. Weber, J.W. Wang, J.R. Cannon, and J.L. Freeman. 2014. Novel dose-dependent alterations in excitatory GABA during embryonic development associated with lead (Pb) neurotoxicity. Toxicol. Letters. 229:1-8.
Freeman, J.L., G.J. Weber, S.M. Peterson, and L.H. Nie. 2014. Embryonic ionizing radiation exposure results in expression alterations of genes associated with cardiovascular and neurological development, function, and disease and modified cardiovascular function. Front. Genet. 5:268.
Weber, G.J., M.S. Sepulveda, S.M. Peterson, S.S. Lewis, and J.L. Freeman. 2013. Transcriptome alterations following developmental atrazine exposure in zebrafish are associated with disruption of neuroendocrine and reproductive system function, cell cycle, and carcinogenesis. Toxicol. Sci. 132:458-466.
Freeman, J.L., G.J. Weber, and M.S. Sepulveda. 2013. Fishing for microRNAs in toxicology. In: Micro-RNA in Toxicology and Medicine.
Peterson, S.M., J. Zhang, and J.L. Freeman. 2013. Developmental reelin expression and time point-specific alterations from lead exposure in zebrafish. Neurotox.Teratol. 38C:53-60.
Brown, K.H., K.P. Dobrinski, A.S. Lee, O. Gokcumen, R.E. Mills, X. Shi, W.W.S. Chong, J.Y.H. Chen, P. Yoo, S. David, S.M. Peterson, T. Raj, K.W. Choy, B. Stranger, R.E. Williamson, L.I. Zon, J.L. Freeman*, and C. Lee*.2012. Extensive genetic diversity and strain sub-structuring among zebrafish strains revealed through copy number variant analysis. Proc. Natl. Acad. Sci. USA. 109:529-534.
Peterson, S.M., J. Zhang, G.J. Weber, and J.L. Freeman. 2011. Global gene expression analysis reveals dynamic and developmental stage dependent enrichment of lead (Pb)-induced neurological gene alterations. Environ. Health Perspect. 119:615-621.
Peterson, S.M. and J.L. Freeman. 2009. Cancer cytogenetics in the zebrafish. Zebrafish.6:355-360.
Freeman, J.L., C. Ceol, H. Feng, D.M. Langenau, C. Belair, H.M. Stern, A. Song, B.H. Paw, A.T. Look, Y. Zhou, L.I. Zon, and C. Lee. 2009. Construction and application of a zebrafish array CGH platform. Genes Chromosomes Cancer 48:155-170.
Redon, R. Ishikawa, K.R. Fitch, L. Feuk, G.H. Perry, T.D. Andrews, H. Fiegler, M.H. Shapero, A.R. Carson, W. Chen, E.K. Cho, S. Dallaire, J.L. Freeman, J.R. Gonzalez, M. Gratacos, J. Huang, D. Kalaitzopoulos, D. Komura, J.R. MacDonald, C.R. Marshall, R. Mei, L. Montgomery, K. Nishimura, K. Okamura, F. Shen, M.J. Somerville, J. Tchinda, A. Valsesia, C. Woodwark, F. Yang, J. Zhang, T. Zerjal, J. Zhang, L. Armengol, D.F. Conrad, X. Estivill, C.Tyler-Smith, N.P. Carter, H. Aburatani, C. Lee, K.W. Jones, S.W. Scherer, and M.E. Hurles. 2006. Global variation in copy number in the human genome. Nature 444:444-454.
Associate Professor of Toxicology