Ulrike Dydak, Ph.D.
Research Interests / Training Areas
- Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS)
- Manganese Neurotoxicity
- Parkinson Disease
- GABA MRS and GABA mapping by MEGA spectroscopic imaging
- Fast spectroscopic imaging (MRSI) techniques
- Multi-nuclear MRSI (31P MRS) to monitor response to radiation treatment
After studying physics and mathematics at the University of Vienna, Austria, Dr. Dydak received her PhD and postdoctoral training in physics and engineering of Magnetic Resonance Imaging at the Swiss Federal Institute of Technology (ETH) Zürich, Switzerland. Dr. Dydak’s research is focused on the development of Magnetic Resonance Spectroscopy (MRS) techniques for the noninvasive in-vivo assessment of metabolite and neurotransmitter concentrations, and their application to study physiological and pathophysiological mechanisms. A long-term goal of this research is to translate these novel MRS methods into viable clinical diagnostic procedures that aid in disease detection as well as assessment of treatment response. Special emphasis of her work lies on the development of the in vivo detection and quantification of γ-aminobutyric acid (GABA), an inhibitory neurotransmitter, to study manganese-induced parkinsonian neurotoxicity and idiopathic Parkinson Disease. A second focus lies on the development of whole-liver phosphorous (31P) magnetic resonance spectroscopic imaging of the human liver to improve treatment monitoring in liver cancer.
Dr. Dydak holds an adjunct appointment at the Department of Radiology and Imaging Sciences at IU School of Medicine (link to http://imaging.medicine.iu.edu), where part of her research lab is located. She also holds an adjunct appointment at the Department of Biomedical Engineering at IUPUI, and a courtesy appointment with the Department of Speech, Language and Hearing Sciences at Purdue University.
Recent / Representative Publications
Poole VN, Abbas K, Shenk TE, Breedlove EL, Breedlove KM, Robinson ME, Leverenz LJ, Nauman EA, Talavage TM, Dydak U (2014). MR Spectroscopic Evidence of Brain Injury in the Non-Diagnosed Collision Sport Athlete. Dev Neuropsychol. 2014;39(6):459-73.
Yildiz A, Quetscher C, Dharmadhikari S, Chmielewski W, Glaubitz B, Schmidt-Wilcke T, Edden R, Dydak U (2014). Beste C. Feeling safe in the plane: neural mechanisms underlying superior action control in airplane pilot trainees – a combined EEG/MRS study. Hum Brain Mapp. 2014 Apr 18. doi: 10.1002/hbm.22530. [Epub ahead of print]
Long Z, Jiang YM, Li XR, Fadel W, Xu J, Yeh CL, Long LL, Luo HL, Harezlak J, Murdoch JB, Zheng W, Dydak U (2014). Vulnerability of Welders to Manganese Exposure–A Neuroimaging Study, NeuroToxicology, Available online 27 March 2014, ISSN 0161-813X
Long Z, Li XR, Xu J, Edden RA, Qin WP, Long LL, Murdoch JB, Zheng W, Jiang YM, Dydak U (2014). Thalamic GABA Predicts Fine Motor Performance in Manganese-Exposed Smelter Workers. PLoS One. 2014 Feb 4;9(2):e88220. PMCID 3913772.
Xu, J, Dydak U, Harezlak J, Nixon J, Dzemidzic M, Gunn A.D., Karne H.S., Anand A (2013). Neurochemical Abnormalities in Unmedicated Bipolar Depression and Mania: a 2D 1H MRS Investigation. Psychiatry Res. 2013 Sep 30;213(3):235-41. PMCID 3729606
Long Z, Medlock C, Dzemidzic M, Shin YW, Goddard A, Dydak U (2013). Decreased GABA levels in Anterior Cingulate Cortext/Medial Prefrontal Cortex in Panic Disorder. Prog Neuropsychopharmacol Biol Psychiatry 44:131-5, PMCID 3758115
Panda A, Jones S, Raghavan RS, Sandrasegaran K, Bansal N, Dydak U (2012). Phosphorus Liver MRSI at 3T Using a Novel Dual Tuned 8-Channel 31P/1H Coil. Magnetic Resonance in Medicine 68:1346-56 PMCID 22287206
Dydak U, Jiang YM, Long LL, Zhu H, Chen J, Li WM, Edden RAE, Hu S, Fu X, Long Z, Meier D, Harezlak J, Aschner M, Murdoch JB, Zheng W (2011). In Vivo Measurement of Brain GABA Concentrations by Magnetic Resonance Spectroscopy in Smelters Occupationally Exposed to Manganese. Environ Health Perspect.119:219-224, 2011. Epub 2010 Sep 28. PMC3040609.
Full publication list:
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