Jason Cannon, Ph.D.
Research Interests/Training Areas
- Dietary toxicants and neurological disease
- Environmentally-induced autophagy disruptions
- Gene-environment interactions in Parkinson’s disease
Jason Cannon is an Associate Professor of Toxicology in the School of Health Sciences at Purdue University in West Lafayette. He received his B.S. in Physiology from Michigan State University, his Ph.D. in Toxicology from the University of Michigan, and was a postdoctoral fellow at the Pittsburgh Institute of Neurodegenerative Diseases at the University of Pittsburgh. He teaches courses in analytical, pathological, and biochemical toxicology and performs mechanistic research on the environmental bases of Parkinson’s disease. His research group is particularly interested in the following topics related to Parkinson’s disease: 1) Neurotoxicity of heterocyclic amines, which are compounds formed during high temperature cooking; 2) How environmental insults may disrupt autophagy and lead to neuronal cell death; 3) How specific genetic factors can increase sensitivity to environmental insults. The lab utilizes neurobehavioral, biochemical, and histological techniques to address these topics.
Lee, J. W., Tapias, V., Di Maio, R., Greenamyre, J. T. and Cannon, J. R. (2015). Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiol Aging 36(1), 505-18, 10.1016/j.neurobiolaging.2014.07.011.
Griggs, A. M., Agim, Z. S., Mishra, V. R., Tambe, M. A., Director-Myska, A. E., Turteltaub, K. W., McCabe, G. P., Rochet, J. C. and Cannon, J. R. (2014). 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Is Selectively Toxic to Primary Dopaminergic Neurons In Vitro. Toxicol Sci 140(1), 179-89, 10.1093/toxsci/kfu060.
O'Neal, S. L., Lee, J. W., Zheng, W. and Cannon, J. R. (2014). Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity. Neurotoxicology 44C, 303-313, 10.1016/j.neuro.2014.08.001.
Cannon, J. R. and Greenamyre, J. T. (2013). Gene-environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models. Neurobiol Dis 57C, 38-46, 10.1016/j.nbd.2012.06.025.
Cannon, J. R., Geghman, K. D., Tapias, V., Sew, T., Dail, M. K., Li, C. and Greenamyre, J. T. (2013). Expression of human E46K-mutated alpha-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment. Exp Neurol 240, 44-56, 10.1016/j.expneurol.2012.11.007.
Cannon, J. R., Tapias, V., Na, H. M., Honick, A. S., Drolet, R. E. and Greenamyre, J. T. (2009). A highly reproducible rotenone model of Parkinson's disease. Neurobiol Dis 34(2), 279-90.
Full publication list:
Purdue Interdisciplinary Life Science Program (PULSe) link:
Associate Professor of Toxicology