Valerie Knopik, PhD

Research Interests

ADHD, gene-environment interplay, epigenetics, prenatal substance exposure, development of externalizing behavior problems, reading, language, and executive function deficits, and substance use, the effects of yoga and mindfulness on quality-of-life and well-being

Biography

I received my PhD from the Institute for Behavioral Genetics and the University of Colorado, Boulder in 2000 and went on to complete a postdoctoral fellowship in Psychiatric and Genetic Epidemiology at Washington University School of Medicine in St Louis; staying on there as junior faculty until 2004. In 2004, I joined the faculty of the Center for Alcohol and Addiction Studies and the Department of Community Health at Brown University. From 2009-2017, I joined the Department of Psychiatry and Human Behavior at Brown, where I also served as the Director of the Division of Behavioral Genetics at Rhode Island Hospital. In August 2017, I joined the faculty at Purdue as the Ben and Maxine Miller Professor of Human Development and Family Studies.

My primary program of research focuses on the joint effects of genetic, epigenetic, and environmental (specifically prenatal and early postnatal) risk factors on birth outcomes, externalizing behavior (ADHD, conduct disorder), associated learning and cognitive deficits, and subsequent substance use.  

In addition to my primary area of interest, I currently collaborate as a statistical geneticist with local, national, and international scientists on several NIH-funded research projects including, but not limited to: the Center for the Computational Biology of Human Disease at Brown University (NIGMS, PI Rand), genetics and cannabis-related outcomes (NIDA; Co-PIs Metrik and Knopik; PI Haney), sleep genetics (NIMH, PI Carskadon), genetics and adolescent alcohol use disorder (NIAAA, NICHD; PI Heath), biobehavioral markers of pediatric bipolar disorder (NIMH; PI Dickstein), family interventions for adolescent substance use (NIAAA, PI Spirito), genetics and reward learning (NIDA; PI Beevers), and suicide genetics (NIMH; Co-PIs Armey and Miller; PI Nugent). My research is inherently collaborative and interdisciplinary, integrating across research traditions and study designs and involves a comprehensive approach, which incorporates community as well as high-risk genetically-informed samples.

I am currently the primary mentor on multiple NIH career development awards focused on biobehavioral pathways of development to adolescent substance use (including genetic, endocrine, prenatal and parental measures (PI Marceau), genetic comorbidity of adolescent smoking and ADHD (PI Bidwell), and methodological approaches to gene-set and gene-network investigations of alcohol dependence (PI Palmer).  

In addition to my research, I serve as Associate Editor for Behavior Genetics and on the editorial board of Psychological Medicine. I am also the lead author on the textbook, Behavioral Genetics (7th edition), which was published in October 2016.

I have a strong commitment to mentoring and have received two Research Mentoring Awards for Outstanding Mentorship from Brown University (2011, 2014).

Selected Publications

*Student, Postdoctoral fellow (current or prior), or trainee

  • *Bidwell, L. C., Balestriari, S., Colby, S., Knopik, V. S., & Tidey, J. (in press). Abstinence-induced withdrawal severity among adolescent smokers with and without ADHD: Disentangling effects of nicotine and smoking reinstatement. Psychopharmacology.

  • *Bidwell, L. C., *Marceau, K., *Brick, L. A., Karoly, H. C., Todorov, A., Palmer, R. H., Heath, A. C., & Knopik, V. S. (in press). Prenatal exposure effects on early adolescent substance use: A genetically-informed Bayesian approach. Addictive Behaviors.

  • Feurer, C., McGeary, J. E., Knopik, V. S., *Brick, L. A., *Palmer, R. H., & Gibb, B. (in press). HPA polygenic reactivity score moderates the impact of interpersonal stress on prospective increases in depressive symptoms for offspring of depressed mothers. Journal of Abnormal Psychology.

  • Huang, H., Zhu, Y., Eliot, M. N., Knopik, V. S., McGeary, J. E., Carskadon, M. A., & Hart, A. C. (in press). Combining human epigenetics and sleep studies in C. elegans: A cross-species approach for finding conserved genes regulating sleep. Sleep.

  • Maddox, W. T., Gorlick, M. A., Koslov, S., McGeary, J. E., Knopik, V. S., & Beevers, C. G. (in press). Serotonin transporter genetic variation is differentially associated with reflexive- and reflective-optimal learning. Cerebral Cortex.

  • *Marceau, K., *Bidwell, L. C., Karoly, H. C., Evans, A., Todorov, A., *Palmer, R. H. C., Heath, A. C., & Knopik, V. S. (in press). Within family effects of smoking during pregnancy on ADHD: The importance of phenotype. Journal of Abnormal Child Psychology.

  • *Micalizzi, L., Marceau, K., Brick, L. A., Palmer, R. H. C., Todorov, A. A., Heath, A. C., Evans, A., & Knopik, V. S. (in press). Inhibitory control in siblings discordant for maternal smoking during pregnancy. Developmental Psychology.

  • Spirito, A., Hernandez, L., *Marceau, K., Cancilliere, M. K., Graves, H. R., Rodriguez, A. M., & Knopik, V. S. (in press). Effects of a brief parent-focused intervention for substance-using adolescents and their siblings.  Journal of Substance Abuse Treatment.

  • *Palmer, R. H. C., Beevers, C., McGeary, J. E., *Brick, L. A., & Knopik, V. S. (2017). A preliminary study of genetic variation in the dopaminergic and serotonergic systems and genome-wide additive genetic effects on depression severity and treatment response. Clinical Psychological Science, 5(1):158-165.

  • Ayorech, Z., Selzam, S., Smith-Wooley, E., Knopik, V. S., Neiderhiser, J., DeFries, J. C., & Plomin, R. (2016). Publication trends over 55 years of behavioral genetic research. Behavior Genetics, 46(5): 603-607.

  • *Bidwell, L. C., *Palmer, R. H. C., *Brick, L., Heath, A. C., Madden, P. A. F., & Knopik, V. S. (2016). A propensity scoring approach to characterizing the effects of maternal smoking during pregnancy on offspring’s initial responses to cigarettes and alcohol. Behavior Genetics, 46(3): 416-430.

  • *Bidwell, L. C., *Palmer, R. H. C., *Brick, L., McGeary, J. E., & Knopik, V. S. (2016). Genome-wide SNP heritability of nicotine dependence as a multidimensional phenotype. Psychological Medicine, 46(10): 2059-2069.

  • Burkhouse, K., Woody, M. L., Owens, M. J., McGeary, J. E., Knopik, V. S., & Gibb, B. E. (2016). Sensitivity in detecting facial displays of emotion: Impact of maternal depression and oxytocin receptor genotype. Cognition and Emotion, 30(2): 275-287.

  • Knopik, V. S. (2016). Behavioral genetics: Psychological perspectives. In J. D. Wright (Ed.), International encyclopedia of the behavioral and social sciences (2nd edition).

  • Knopik, V. S., *Marceau, K., *Bidwell, L. C., *Palmer, R. H. C., *Smith, T. F., Todorov, A., Evans, A., & Heath, A. C. (2016). Smoking during pregnancy and ADHD risk: A genetically informed and multiple rater approach. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics, Oct;171(7):971-81.

  • Knopik, V. S., *Marceau, K., *Palmer, R. H. C., *Smith, T. F., & Heath, A. C. (2016). Maternal smoking during pregnancy and offspring birth weight: A genetically-informed approach comparing multiple raters. Behavior Genetics, 46: 353-364.

  • Knopik, V. S., Neiderhiser, J. M., de Geus, E., & Boomsma, D. I. (2016). The importance of the prenatal environment in behavioral genetics: Introduction to special issue. Behavior Genetics, 46: 281-285.

  • Kudinova, A. Y., Deak, T., Hueston, C. M., McGeary, J. E., Knopik, V. S., *Palmer, R. H. C., & Gibb, B. E. (2016). Cross-species evidence for the role of interleukin-33 in depression risk. Journal of Abnormal Psychology, 125(4): 482-494.

  • *Marceau, K., McMaster, M. T. B., *Smith, T. F., Daams, J. G., Beijsterveldt, C. E. M., Boomsma, D. I., & Knopik, V. S. (2016). The prenatal environment in twin studies: A review on chorionicity. Behavior Genetics, 46(3): 286-303.

  • *Marceau, K., Neiderhiser, J. M., Knopik, V. S., Lichtenstein, P., Spotts, E., Ganiban, J., & Reiss, D. (2016). Adolescent age moderates genetic and environmental influences on parent-adolescent positivity and negativity: Implications for genotype-environment correlation. Development and Psychopathology, 28: 149-166.

  • *Marceau, K., *Palmer, R. H. C., Neiderhiser, J. M., McGeary, J. E., *Smith, T. F., & Knopik, V. S. (2016). Passive rGE or developmental gene-environment cascade? An investigation of the role of xenobiotic genes in the association between smoking during pregnancy and child birthweight. Behavior Genetics, 46(3): 365-377.

  • Metrik, J., Aston, E., Kahler, C., Rohsenow, D., McGeary, J., Knopik, V. S., & MacKillop, J. (2016). Cue-elicited increases in incentive salience for marijuana: Craving, demand, and attentional bias. Drug and Alcohol Dependence, Oct 1; 167:82-8.

  • Owens, M., Johnson, A., Burkhouse, K., McGeary, J., Knopik, V. S., *Palmer, R. H. C., & Gibb, B. (2016). Eye tracking indices of attentional bias in children of depressed mothers: Polygenic influences help to clarify previous mixed findings. Development and Psychopathology, 28(2): 385-397.

  • *Palmer, R. H. C., *Bidwell, L. C., Heath, A. C., Brick, L., Madden, P. A. F., & Knopik, V. S. (2016). Maternal smoking during pregnancy and offspring externalizing problems: A propensity score approach. Behavior Genetics, 46(3): 403-415.

  • *Palmer, R. H. C., *Nugent, N., *Brick, L., Bidwell, L. C., McGeary, J. E., Keller, M. C., & Knopik, V. S. (2016). Evidence of shared genome-wide additive genetic effects on vulnerability to drug dependence and trauma exposure in a population of substance users. Journal of Traumatic Stress, 29(3): 197-204.

  • Pearson, R., *Palmer, R. H. C., *Brick, L. A., McGeary, J. E., Knopik, V. S., & Beevers, C. (2016). Additive genetic contribution to symptom dimensions in major depressive disorder. Journal of Abnormal Psychology, 125(4): 495-501.

  • Plomin, R., DeFries, J. C., Knopik, V. S., & Neiderhiser, J. M. (2016). Top 10 replicated findings from behavioral genetics. Perspectives in Psychological Science, 11(1): 3-23.

  • *Smith, T. F., Schmidt-Kastner, R., McGeary, J. E., Kaczorowski, J. A., & Knopik, V. S. (2016). Prenatal ischemia-hypoxia, the ischemia-hypoxia response pathway, and ADHD risk: A multi-omic perspective. Behavior Genetics, 46(3): 467-477.

  • Woody, M. L., Kudinova, A. Y., McGeary, J. E., Knopik, V. S., *Palmer, R. H. C., & Gibb, B. E. (2016). Influence of maternal depression on children’s brooding rumination: Moderation by CRHR1 TAT haplotype. Cognition and Emotion, 30(2): 302-314.

  • *Bidwell, L. C., Knopik, V. S., Audrain-McGovern, J., Glynn, T. R., Spillane, N. S., Ray, L. A., Riggs, N. R., Guillot, C., Pang, R. D., & Leventhal, A. M. (2015) Novelty seeking as a phenotypic marker of adolescent substance use. Substance Abuse: Research and Treatment, 9(Suppl 1):1-10.

  • *Bidwell, L. C., McGeary, J., Gray, J., *Palmer, R., Knopik, V. S., & MacKillop, J. (2015). NCAM1-TTC12-ANKK1-DRD2 polymorphisms and smoking motives as intermediate phenotypes for nicotine dependence. Psychopharmacology, 232(7):1177-86.

  • *Bidwell, L. C., McGeary, J. E., Gray, J., *Palmer, R. H. C., Gray, J., Knopik, V. S., & MacKillop, J. (2015). Associations between dopamine-linked genetic variation and smoking motives in African Americans. Pharmacology, Biochemistry and Behavior, 138:104-10.

  • Blanco, N. J., Love, B. C., Cooper, J. A., McGeary, J. E., Knopik, V. S., & Maddox, W. T. (2015). A frontal dopamine system for reflective exploratory behavior. Neurobiology of Learning and Memory, 123:84-91. 

  • Gorlick, M. A., Worthy, D. A., Knopik, V. S., McGeary, J. E., Beevers, C., & Maddox, W. T. (2015). DRD4 7 repeat carriers show enhanced selective attention to high-priority items in the environment. Journal of Cognitive Neuroscience, 27(3):509-21.

  • Knopik, V. S., Heath, A. C., *Marceau, K., *Palmer, R. H. C., McGeary, J. E., Todorov, A., & Evans, A. (2015). Missouri mothers and their children (MO-MATCH): A family study of the prenatal environment. Twin Research and Human Genetics, 18(5): 485-496.

  • Kudinova, A. Y., McGeary, J. E., Knopik, V. S., & Gibb, B. E. (2015). Brain derived neurotrophic factor (BDNF) polymorphism moderates the interactive effect of 5-HTTLPR polymorphism and childhood abuse on diagnoses of major depression in women. Psychiatry Research, 225(3):746-7.

  • Metrik, J., Aston, E. R., Kahler, C. W., Rohsenow, D. J., McGeary, J. E., & Knopik, V. S. (2015). Marijuana’s acute effects on cognitive bias for affective and marijuana cues. Experimental and Clinical Psychopharmacology, 23(5):339-50.

  • *Palmer, R. H. C., *Brick, L., *Nugent, N., *Bidwell, L. C., McGeary, J. E., Knopik, V. S., & Keller, M. (2015). Examining the role of common genetic variants on alcohol, tobacco, cannabis, and illicit drug dependence.  Addiction, 110(3):530-7.

  • *Palmer, R. H. C., McGeary, J. E., Heath, A. C., Keller, M. C., & Knopik, V. S. (2015). Evidence for shared additive genetic influences on DSM-IV criteria for alcohol dependence. Addiction, 110(12):1922-31.

  • Spirito, A., Hernandez, L., Cancilliere, M. K., Graves, H., Knopik, V. S., & Barnett, N. (2015). Improving parenting and parent-adolescent communication to delay or prevent the onset of alcohol and drug use in young adolescents with emotional/behavioral disorders: A pilot trial. Journal of Child and Adolescent Substance Use, 24(5): 308-322.

  • Xie, Z., Maddox, W. T., Knopik, V. S., McGeary, J. E., & Chandrasekaran, B. (2015). Dopamine receptor D4 (DRD4) gene modulates the influence of informational masking on speech recognition. Neuropsychologia, 67:121-31.

  • Knopik, V. S., *Bidwell, L. C., *Flessner, C., *Nugent, N., Swenson, L., Bucholz, K. K., Madden, P. A. F., & Heath, A. C. (2014). DSM-IV defined conduct disorder and oppositional defiant disorder: An investigation of shared liability in female twins. Psychological Medicine, 44(5), 1053-1064.

  • Xu, X., Clark, U. S., David, S. P., *Mulligan, R. C., Knopik, V. S., McGeary, J., MacKillop, J., McCaffery, J., Niuara, R., & Sweet, L. (2014). The effects of nicotine deprivation and replacement on BOLD-fMRI response to smoking cues as a function of DRD4  VNTR genotype. Nicotine and Tobacco Research, 16(7):939-47.

  • *Bidwell, L. C., Metrik, J., McGeary, J., *Palmer, R. H. C, *Francazio, S., & Knopik, V. S. (2013). Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems. Journal of Studies on Alcohol and Drugs, 74(6):867-78. PMCID: PMC3817049

  • *Boisvert, D., Wright, J. P., Knopik, V. S., & Vaske, J. (2013). A twin study of sex differences in self-control. Justice Quarterly, 30: 529-559.

  • *Maccani, M. A., Padbury, J., Lester, B. M., Knopik, V. S., & Marsit, C. (2013). Placental miRNA expression profiles associated with measures of infant neurobehavioral outcomes. Pediatric Research, 74(3):272-8. PMCID:PMC3766495

  • Miranda, Jr., R., Reynolds, E., Ray, L., Justus, A., Knopik, V. S., McGeary, J., & Meyerson, L. A. (2013). Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents. Alcoholism: Clinical and Experimental Research, 37(2):325-31. PMCID:PMC3700411

  • *Palmer, R. H. C., Knopik, V. S., Young, S. E., Hopfer, C. J., Corley, R. C., Stallings, M. C., Rhee, S. H., & Hewitt, J. K. (2013). Prospective effects of adolescent indicators of behavioral disinhibition on DSM-IV alcohol, tobacco, and illicit drug dependence in young adulthood. Addictive Behaviors, 38(9):2415-21. PMCID: PMC3681900

  • *Smith, T., *Maccani, M. A., & Knopik, V. S. (2013). Epigenetics and the law: Maternal smoking during pregnancy and child behavioral problems. Hastings Law Journal, 64(6): 1619-1648.

  • Wells, T. T., Beevers, C. G., Knopik, V. S., & McGeary, J. E. (2013). Dopamine D4 receptor gene variation is associated with context-dependent attention for emotion stimuli. International Journal of Neuropsychopharmacology, 16(3):525-34. PMCID:PMC3799761

  • *Boisvert, D., Wright, J. P., Knopik, V. S., & Vaske, J. (2012). Genetic and environmental overlap between low self-control and delinquency. Journal of Quantitative Criminology, 28(3), 477-507.

  • Burkhouse, K. L., Uhrlass, D. J., Stone, L. B., Knopik, V. S., & Gibb, B. E. (2012). Expressed emotion criticism and risk of depression onset in children. Journal of Clinical Child and Adolescent Psychology, Nov;41(6):771-7. PMCID: PMC3493706

  • Carskadon, M. A., Sharkey, K. M., Knopik, V. S., & McGeary, J. E. (2012). Short sleep as an environmental exposure: A preliminary study associating 5-HTTLPR genotype to self-reported sleep duration and depressed mood in first-year university students. Sleep, Jun 1;35(6):791-6. PMCID: PMC3353054

  • Josephs, B., Telch, M. J., Hixon, J. G., Evans, J. J., Lee, H., Knopik, V. S., McGeary, J. E., Hariri, A. R., & Beevers, C. G. (2012). Genetic and hormonal sensitivity to defeat: Three studies testing a serotonin transporter genotype x endogenous testosterone interaction. Psychoneuroendocrinology, Jun;37(6):752-61. PMCID: PMC3262096

  • Knopik, V. S., *Maccani, M., *Francazio, S., & McGeary, J. E. (2012). The epigenetics of maternal cigarette smoking during pregnancy and effects on child development. Development and Psychopathology, Nov;24(4):1377-90. PMCID: PMC3581096

  • *Maccani, M., & Knopik, V. S. (2012). Cigarette smoke exposure-associated alterations to noncoding RNA. Frontiers in Genetics, 3:53. PMCID: PMC3321413

  • *Palmer, R. H., *Francazio, S., McGeary, J. E., Lander, A. D., Heath, A. C., & Knopik, V. S. (2012). The genetics of alcohol dependence: Advancing towards systems-based approaches. Drug and Alcohol Dependence, Oct 1;125(3):179-91.  PMCID:PMC3470479

  • Parade, S., McGeary, J. E., Seifer, R., & Knopik, V. S. (2012). Infant development in a family context: Call for a genetically informative approach. Frontiers in Behavioral and Psychiatric Genetics, 3:167. PMCID: PMC3432496

  • Burkhouse, K. L., Gibb, B. E., Coles, M. E., Knopik, V. S., & McGeary, J. E.  (2011). Serotonin transporter genotype moderates the link between children’s report of overactive parenting and their behavioral inhibition.  Journal of Abnormal Child Psychology, 39(6): 783-390. PMCID: PMC3152444

  • Clasen, P., Wells, T., Knopik, V. S., McGeary, J. E., & Beevers, C. (2011). 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination. Genes, Brain and Behavior, Oct;10(7):740-6. PMCID: PMC3401070

  • Gibb, B. E., Johnson, A. L., Benas, J. S., Uhrlass, D. J., Knopik, V. S.,  & McGeary, J. E. (2011). Children’s 5HTTLPR genotype moderates the link between maternal criticism and attentional biases specifically for facial displays of anger. Emotion and Cognition, 25(6):1104-20. PMCID: PMC3170093

  • Knopik, V. S. (2011). Grand challenge in behavioral and psychiatric genetics: Quantitative challenges to keeping up with molecular advances. Frontiers in Genetics 2(9). doi10.3389/fgene.2011.00009

  • Knopik, V. S. (2010). Smoking during pregnancy: Genes and environment weigh in. International Journal of Epidemiology. PMCID: PMC3004721

  • MacKillop, J., Obasi, E., Amlung, M., McGeary, J. E., & Knopik, V. S. (2010). The role of genetics in nicotine dependence: Mapping the pathways from genome to syndrome. Current Cardiovascular Risk Reports, 4(6):446-453. PMCID: PMC3114454

  • Miranda, Jr., R., Ray, L., Justus, A., Meyerson, L. A., Knopik, V. S., McGeary, J., & Monti, P. M. (2010). Initial evidence of an association between OPRM1 and adolescent alcohol misuse. Alcoholism: Clinical and Experimental Research, 34(1):112-22. PMID: 19860800

  • Knopik, V. S. (2009). Maternal smoking during pregnancy and child outcomes: Real or spurious effect? Developmental Neuropsychology, 34, 1-36. PMCID: PMC3581055

  • Knopik, V. S., Heath, A. C., Bucholz, K. K., Madden, P. A .F., & Waldron, M. (2009). Genetic and environmental influences on externalizing behavior and alcohol problems in adolescence: A female twin study. Pharmacology, Biochemistry, and Behavior, 93(3):313-21. PMCID: PMC2758781

  • Knopik, V. S., Jacob, T., Haber, R., *Swenson, L. P., & Howell, D. (2009). Paternal alcoholism and offspring ADHD problems: A children-of-twins design. Twin Research and Human Genetics, 12(1), 53-62. PMCID: PMC3581080

  • Agrawal, A., Knopik, V. S., Pergadia, M. L., Waldron, M., Bucholz, K. K., Martin, N. G., Madden, P. A. F., & Heath, A. C. (2008). Evaluating measured correlates of cigarette smoking during pregnancy and its genetic and environmental overlap with smoking progression. Nicotine and Tobacco Research, 10(4), 567-78. PMID: 18418779

  • *Ray, L., Rhee, S. H., Stallings, M. C., Knopik, V. S., & Hutchison, K. E. (2007). Examining the heritability of tension reduction after cigarette smoking: Results from an experimental twin study. Twin Research and Human Genetics, 10, 546-553. PMID: 17708695

  • Knopik, V. S., Heath, A. C., Jacob, T., Slutske, W. S., Bucholz, K. K., Madden, P. A. F., Waldron, M., & Martin, N. G. (2006). Maternal alcohol use disorder and offspring ADHD: Disentangling genetic and environmental effects using a children-of-twins design. Psychological Medicine, 36(10), 1461-1472. PMID: 16734942

  • Knopik, V. S., Sparrow, E. P., Madden, P. A. F., Bucholz, K. K., Hudziak, J. J., Reich, W., Slutske, W. S., Grant, J. D., McLaughlin, T. L., Todorov, A., Todd, R. D., & Heath, A. C.  (2005). Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk: A female twin study. Psychological Medicine, 35(5), 625-635. PMID: 15918339

  • Knopik, V. S., Heath, A. C., Madden, P. A. F., Bucholz, K. K., Slutske, W. S., Nelson, E. C., Statham, D., Whitfield, J. B., & Martin, N. G. (2004). Genetic effects on alcohol dependence risk: Re-evaluating the importance of psychiatric and other heritable risk factors. Psychological Medicine, 34, 1519-1530. PMID: 15724882

  • Nelson, E. C., Heath, A. C., Bucholz, K. K., Madden, P. A. F., Fu, Q., Knopik, V. S., Lynskey, M. T., Whitfield, J. B., Statham, D. J., & Martin, N. G. (2004). The genetic epidemiology of alcoholic blackouts. Archives of General Psychiatry, 61(3), 257-263. PMID: 14993113

  • Heath, A. C., Knopik, V. S., Madden, P. A. F., Neuman, R. J., Lynskey, M. J., Slutske, W. S., Jacob, T., & Martin, N. G. (2003). Accuracy of mothers’ retrospective reports of smoking during pregnancy: Comparison with twin sister informant ratings. Twin Research, 6(4), 297-301. PMID: 14511436

  • Knopik, V. S., Smith, S. D., Cardon, L. R., Pennington, B. F., Gayán, J., Olson, R. K., & DeFries, J. C. (2002). Differential genetic etiology of reading component processes as a function of IQ. Behavioral Genetics, 32(3), 181-198. PMID: 12141780

  • Willcutt, E. G., Pennington, B. F., Smith, S. D., Cardon, L. R., Gayán, J., Knopik, V. S., Olson, R. K., & DeFries, J. C. (2002). Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for Attention-Deficit/Hyperactivity Disorder. Neuropsychiatric Genetics, 114, 260-268. PMID: 11920845

  • Davis, C. J., Gayán, J., Knopik, V. S., Smith, S. D., Cardon, L. R., Pennington, B. F., Olson, R. K., & DeFries, J. C. (2001). Etiology of reading difficulties and rapid naming: The Colorado Twin Study. Behavior Genetics, 31(6), 625-635. PMID: 11838539

  • Davis, C. J., Knopik, V. S., Olson, R. K., Wadsworth, S. J., & DeFries, J. C. (2001). Genetic and environmental influences on rapid naming and reading ability: A twin study. Annals of Dyslexia, 51, 231-247.

  • Alarcón, M., Knopik, V. S., & DeFries, J. C. (2000). Covariation of mathematics achievement and general cognitive ability. Journal of School Psychology, 38(1), 63-77.

  • Davis, C. J., Knopik, V. S., Wadsworth, S. J., & DeFries, J. C. (2000). Self-reported reading problems in parents of twins with and without reading difficulties. Twin Research, 3(2), 88-91. PMID: 10918621

  • Wadsworth, S. J., Knopik, V. S., & DeFries, J. C. (2000). Reading disability in boys and girls: No evidence for a differential genetic etiology. Reading and Writing: An Interdisciplinary Journal, 13, 133-145.

  • Knopik, V. S., & DeFries, J. C. (1999). Etiology of covariation between reading and mathematics performance: A twin study. Twin Research, 2, 226-234. PMID: 10555134

  • Knopik, V. S., Alarcón, M., & DeFries, J. C. (1998). Common and specific gender influences on individual differences in reading performance: A twin study. Personality and Individual Differences, 25, 269-277.

  • Knopik, V. S., & DeFries, J. C. (1998). A twin study of gender-influenced individual differences in general cognitive ability. Intelligence, 26(2), 81-89.

  • Knopik, V. S., Alarcón, M., & DeFries, J. C. (1997). Comorbidity of mathematics and reading deficits: Evidence for a genetic etiology. Behavior Genetics, 27(5), 447-453. PMID: 9336081

  • Knopik, V. S., DeFries, J. C., & Alarcón, M. (1996). Gender differences in cognitive abilities of opposite-sex and same-sex twin pairs with reading disability. Annals of Dyslexia, 46, 241-257.

Education

  • Postdoctoral Fellow, 2000-2002, Psychiatry/Genetic Epidemiology, Washington University School of Medicine, St Louis, Missouri

  • PhD, 2000, Psychology (Behavioral Genetics), University of Colorado, Boulder

  • MS, 1999, Psychology (Behavioral Genetics), University of Colorado, Boulder

  • BA, 1994, Psychology and Sociology, Wesleyan College

Honors

  • 2017: Fulker Award, Behavior Genetics Association

  • 2014, 2015: David J. Fish Research Scholar Award, Department of Psychiatry, Rhode Island Hospital

  • 2014: Outstanding Research Mentor Award, Brown University

  • 2011: Psychology Research Mentor Award for Outstanding Mentorship, Brown University

  • 2010: Lifespan Executive Mentorship Program

  • 2009: Young Alumna Award for Outstanding Professional Achievement, Wesleyan College

  • 2007: Behavior Genetics Association Fuller & Scott Early Career Award

  • 2007: NIDA Genetics Workgroup funds for Behavior Genetics Association 2007 symposium

  • 2006: Research Excellence Award, Brown University

  • 2003: ADHD Molecular Genetics Network Travel Award

  • 2002, 2003: Research Society for Alcoholism Enoch Gordis Research Recognition Award finalist

  • 2002, 2003: Research Society for Alcoholism Junior Investigator Award

Recent External Grants

  • 2017-2022: Co-Investigator. The Kinship Risk Score: An Integrative Tool to Prioritize Alcohol and Drug-Addiction Related Genes for Enhanced Risk Prediction, NIDA.
  • 2016-2021: Co-Investigator.Center for Biomedical Research Excellence (COBRE) in Computational Biology of Human Disease, NIH-NIGMS.
  • 2016-2018: Co-Investigator.The Temporal Assocation between Alcohol and Dating Violence: Moderators in Young Adult Couples, NIAAA.
  • 2016-2017: Co-Investigator.Contribution of Genome-wide Variation to Cognitive Vulnerability to Depression, NIMH.
  • 2015-2020: Co-Investigator.Biomarkers, Social, and Affective Predictors of Suicidal Thoughts and Behaviors in Adolescents, NIMH.
  • 2012-2017, in NCE until 2018: Co-Investigator.Genetic Influences on Dual Processing Modes of Reward and Punishment Learning, NIH.
  • 2012-2017, in NCE until 2018: Co-Investigator.Multi-Method Assessment of Emotion Reactivity: Translational Research in Suicide, NIMH.
  • 2012-2016: Co-Investigator.Children’s Attentional Biases: A Key Component of Negative Valence Systems, NIMH.
  • 2011-2014: Co-I/PI of RI Hospital subcontract.Impact of Receptor Polymorphisms on Sensations from Common Oral Irritants, NIH.
  • 2010-2015: Co-Investigator.Marijuana Relapse: Influence of Tobacco Cessation and Varenicline, NIDA.
  • 2009-2014: Co-Investigator.Bio-Behavioral Markers of Bipolar Conversion, NIMH.
  • 2008-2014: Principal Investigator.Prenatal Tobacco Exposure: Effects on Neuropsychological Outcomes and ADHD, NIDA.
  • 2008-2013: Co-Investigator.Prospective Study of Depressed Mood: Short Sleep and Serotonergic Genes, NIMH.

Professional Service

  • 2015-pres: PhenX Expert Review Panel: Alcohol, Tobacco, and Other Substances domain (PhenX Toolkit (https://www.phenxtoolkit.org/) funded by National Human Genome Research Institute (NHGRI))
  • 2014-pres: Editorial Board, Psychological Medicine
  • 2013-2016: Secretary (elected by international society membership), Behavioral Genetics Association (3-year term)
  • 2010-pres: Editorial Board, Frontiers in Child and Neurodevelopmental Psychiatry
  • 2009-pres: Associate Editor, Behavior Genetics

Scientific Grant Reviewer

  • 2016: NIH Review Ranking Pilot Study – working with NIH to assess the assumption that highly meritorious applications are evenly distributed across study sections
  • 2016: Invited reviewer: Scientific Grant Review (Jan 2016), NIH, Special Emphasis Panel ZHD1 DSR(H) CB1 Multivariate Genetics and Genomics of Reading Comprehension and Related Cognition
  • 2016: Invited reviewer: Scientific Grant Review (Jan 2016), CDC, Special Emphasis Panel ZDP1 KVA (A2) Pregnancy Risk Assessment Monitoring System, Component A
  • 2015: Invited reviewer: Scientific Grant Review (Feb 2015), NIMH Cooperative Agreement Review Meeting – Longitudinal Assessment of Post-traumatic Syndromes
  • 2014: Invited reviewer: Scientific Grant Review Medical Research Council (MRC), United Kingdom
  • 2014: Invited reviewer: Scientific Grant Review Netherlands Organization for Scientific Research (NWO)
  • 2011-2015: Member, Behavioral Genetics and Epidemiology Study Section (BGES), Center for Scientific Review, NIH
  • 2011-2010: ZHD1 DSR-H (53) R Learning Disabilities: Multidisciplinary Research Centers.
  • 2011: Invited reviewer: Scientific Grant Review NICHD, Child Behavior and Development Branch
  • 2011: Invited reviewer: Scientific Grant Review, NIH, Special Emphasis Panel, Chronic Diseases, ZRG1 PSE M03
  • 2011: Invited reviewer: Scientific Grant Review, NIH, Special Emphasis Panel, Accelerating the Pace of Drug Abuse Research Using Existing Epidemiology, Prevention, and Treatment Research Data, ZRG1 PSE G55
  • 2011: Invited reviewer: Scientific Grant Review (March 2011) CDC, Special Emphasis Panel evaluating FOA #: DP11-001: Pregnancy Risk Assessment Monitoring System (PRAMS)
  • 2010: Invited reviewer: Scientific Grant Review (Oct 2010) NIH, Behavioral Genetics and Epidemiology (BGES) IRG
  • 2010: Invited reviewer: Scientific Grant Review, NIH, Special Emphasis Panel, Deep Sequencing and Analysis of Pharmacogenomic Regions: Discovery and Analysis of Genetic Variants Contributing to Drug Abuse and Addiction
  • 2010: Invited reviewer: Scientific Grant Review (June 2010) NIH, Special Emphasis Panel, ZRG1 PSE-E 50, Accelerating the Pace of Drug Abuse Research Using Existing Epidemiology, Prevention, and Treatment Research Data
  • 2009: Invited reviewer: Scientific Grant Review (Oct 2009) NIH, Child Psychopathology & Developmental Disabilities (CPDD) IRG
  • 2009: Invited reviewer: Scientific Grant Review (June 2009) NIH,  Biobehavioral and Behavioral Processes (BBBP-C) IRG
  • 2009: Invited reviewer: Scientific Grant Review (June 2009) John Templeton Foundation
  • 2008: Invited reviewer: Scientific Grant Review (2008) Swiss National Science Foundation
  • 2007: Invited reviewer: Scientific Grant Review (May 2007) NIH, Special Emphasis Panel, Linking Environments, Behaviors, and HIV/AIDS
  • 2007: Invited reviewer: Scientific Grant Review (Feb 2007) NIH, Child Psychopathology & Developmental Disabilities (CPDD) IRG
  • 2006: Invited reviewer: Scientific Grant Review (2006) Netherlands Organization for Health Research and Development
  • 2005: Invited reviewer: Scientific Grant Review (2005) NICHD, Child Behavior and Development Branch ZHD1 DSR-H 27 S, RFA (HD-04-027) Learning Disabilities: Multidisciplinary Research Centers.
  • 2005: Invited reviewer: Scientific Grant Review (2005) The Wellcome Trust, London UK

Ad Hoc Reviewer

Addiction, Alcoholism: Clinical and Experimental Research, American Journal of Medical Genetics-Neuropsychiatric Genetics, American Journal of Psychiatry, Archives of Pediatrics and Adolescent Medicine, Behavior Genetics, Biological Psychiatry, Biological Psychology, BioMed Central Psychiatry, Child Development, International Journal of Epidemiology, JAMA, JAMA Psychiatry (formerly Archives of General Psychiatry), Journal of the American Academy of Child and Adolescent Psychiatry, Journal of Child and Adolescent Mental Health, Journal of Child Psychology and Psychiatry, Journal of Consulting and Clinical Psychology, Journal of Pediatric Psychology, Journal of Neurogenetics, Journal of Research on Adolescence, Journal of Studies on Alcohol, Learning and Individual Differences, Nicotine and Tobacco Research, Neurotoxicology and Teratology, Personality and Individual Differences, Physiology and Behavior, PLOS ONE, Preventative Medicine, Psychiatric Genetics, Psychiatry Research, Psychological Bulletin, Psychological Medicine, Psychological Science, Psychological Reports, Psychology of Addictive Behaviors, Public Health Reports, Scientific Studies of Reading, Twin Research and Human Genetics

Valerie S. Knopik
Ben & Maxine Miller Professor of Human Development and Family Studies

(PhD, 2000)

Fowler Memorial House, Rm 223
Purdue University
1200 West State St.
West Lafayette, Indiana  47907-2055

Phone: 765-494-0942
Fax: 765-496-0503
vknopik@purdue.edu

Purdue University, 610 Purdue Mall, West Lafayette, IN 47907, (765) 494-4600

2016 Purdue University | An equal access/equal opportunity university | Copyright Complaints | Maintained by HDFS

If you have trouble accessing this page because of a disability, please contact HDFS.