Interdisciplinary Life Science - PULSe Great research is a matter of choice

Liang Xue

Liang Xue Profile Picture
Training Group:


Mentor / Lab:

Dr. Andy Tao

Specific Research Area / Project:

Phosphoproteomics, Quantitative proteomics

Undergraduate Institution:

University of Science and Technology of China

Research Profile:

The phosphorylation modification is universally involved in human diseases including cancer. To understand the complex phosphorylation signaling requires the identification of substrates targeted by specific protein kinases. My research has been focusing on the proteomic method development for identifying the substrate specificity and potential substrates for protein kinases. The method called Kinase Assay Linked Phosphoproteomics (KALIP) has been demonstrated to be sensitive and has low false discovery rate for identifying direct kinase substrates. This high throughput method will benefit the signaling transduction society for substrate screening.

Liang Xue Research Picture

About Me:

I have been grateful to have the wonderful opportunity to join the PULSe program with its many diverse research directions from which to choose. During the rotation, I experienced four different types of research, including bioinformatics, plant biology, biotechnology and structure biology. Among them, the power of mass spectrometry based proteomics attracted me, so I decided to join Andy Tao’s group and conducted a series of method development research in the next several years. My PhD training has dramatically changed my mind regarding methodology in biological research. My career goal is to be a system biologist who combines both biotech and basic science into an art of research.


  • Miles Graduate Scholarship Award, Purdue Cancer Center, 2013
  • PULSe Student Publication of the Year Award, Purdue Interdisciplinary Life Science Program, 2013
  • Center for Cancer Research Travel Award, Purdue Cancer Center, 2013
  • Purdue Graduate Student Government Travel Grant, Purdue Graduate Student Government, 2013
  • Dr. Henry A. Morse Award for the annual best publication, Purdue Biochemistry Department, 2012
  • Purdue Graduate Student Government Professional Grant, Purdue Graduate Student Government, 2012
  • PULSe Student Travel Award, Purdue Interdisciplinary Life Science Program, 2011, 2012
  • Excellence Award in Interdisciplinary Graduate Programs for Best Research, Purdue PULSe Program, 2011
  • Beach Family Travel Grant for annual best conference travel proposal, Purdue Biochemistry Department, 2011
  • PULSe Excellence Graduate Student Scholarship, Purdue Interdisciplinary Life Science Program, 2008


  • Xue L, Wang PC, Zhu JK, and Tao WA. Dissect SnRKs signaling network in the ABA pathway based on kinase assay linked phosphoproteomics. Proceedings of the 61th American Society for Mass Spectrometry Conference. 2013. Minneapolis, MN
  • Xue L, Wang PC, Wang LS, Radivojac P, Tang HX, Zhu JK, Arnold R, and Tao WA. Study of plant phosphorylation change in osmotic stress response using label-free quantitative proteomics. Proceedings of the 2010 Biochemistry Research Retreat, Purdue University. 2012. Marshall, IN
  • Xue L, Wang LS, Zhang HM, Wang PC, Radivojac P, Tang HX, Zhu JK, Arnold R, and Tao WA. Library Assisted eXtracted Ion Chromatogram (LAXIC) for Quantitative Phosphoproteomics. Proceedings of the 60th American Society for Mass Spectrometry Conference. 2012. Vancouver, BC, Canada
  • Xue L, Wang WH, Iliuk A, Hu L, Galan JA, Yu S, Hans M, Geahlen RL, and Tao WA. A Proteomic Strategy to Identify Protein Kinase Substrates and Substrate Specificity. Proceedings of the 59th American Society for Mass Spectrometry Conference. 2011. Denver, CO
  • Xue L, Wang LS, Hu L, Iliuk A, Radivojac P, Tang HX, Arnold R, and Tao WA. Phosphoproteomics Based on PolyMAC and Label-Free Quantitation. Proceedings of the 58th American Society for Mass Spectrometry Conference. 2010. Salt Lake City, UT


  • Graduate Student Government at Purdue University, Senator for Biochemistry Department, 2011-2012
  • American Society for Mass Spectrometry, Student Member, 2012-present
  • American Association for the Advancement of Science, Student Member, 2012-present

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