Interdisciplinary Life Science - PULSe Great research is a matter of choice

Jer-Yen Yang

Jer-Yen Yang Profile Picture

Assistant professor-Department of Basic Medical Sciences
UT MD Anderson Cancer Center, Ph.D., 2009; Stanford University, Postdoctoral fellow, 2012


Contact Info:

yang533@purdue.edu
765-496-7363


Training Group(s):
Molecular Signaling and Cancer Biology
Chromatin and Regulation of Gene Expression


Current Research Interests:

Deficiency in the process of embryo development will lead to birth defects and severe disease, such as cancer. The Hedgehog (Hh) pathway is a conserved signaling system essential for embryonic development. I am interest to understand how Hh signaling regulates early neuronal development in zebrafish, mouse and human. Up ligand stimulation, Hh pathway promotes cell proliferation, differential and migration. However, by which and how the positive/negative regulators modulate signals still remain unknown. Mutations that deregulate Hh signalling are directly implicated in basal cell carcinoma and medulloblastoma (pediatric brain tumor) in mouse and human. The mechanisms of Hh pathway activation in cancers in which no pathway mutations have been identified are less clear, but of great translational significance. Using CHIP/CHIP, CHIP/seq, siRNA library screening and proteomics approach, we have identified several important hits for Hh regulation. Now, we would like to verify those candidates and figure out how those genes impact on Hh pathway in chromatin and genes level- transcriptional regulation and protein-post-translational modification.

Highly motivative graduate students are welcome to apply.

My Lab website: http://jyyanglab.weebly.com/index.html



Selected Publications:

Huang, S.Y.: Yang, JY. Targeting the Hedgehog Pathway in Pediatric Medulloblastoma. Cancers 2015, 7, 2110-2123.

Li YH, Luo J, Mosley YY, Hedrick VE, Paul LN, Chang J, Zhang G, Wang YK, Banko MR, Brunet A, Kuang S, Wu JL, Chang CJ, Scott MP, Yang JY. AMP-activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Reports, 2015 Jul 28;12(4):599-609.

Chang CC, Wu MJ, Yang JY, Carmarillo I, Chang CJ. Leptin-STAT3-G9a signaling promotes obesity-mediated breast cancer progression. Cancer Research, 2015 Jun 1;75(11):2375-86.

Zhang G, Yang JY, Cui Z. New insight into cancer aneuploidy in zebrafish. Int Rev Cell Mol Biol. 2015; 314:149-70.

Wu PC, Lu JW, Yang JY, Lin IH, Ou DL, Lin YH, Chou KH, Huang WF, Wang WP, Huang YL, Hsu C, Lin LI, Lin YM, Shen CK, Tzeng TY.  A H3K9 Methyltransferase, KMT1E, Suppresses Lung Cancer Cell Metastasis Through the SMAD2/3 Pathway. Cancer Research, 2014, Dec 15;74(24):7333-43.

Chao CH, Chang CC, Wu MJ, KO HW, Wang D, Hung MC, Yang JY, Chang CJ. Dysregulated miR-205 signaling promotes symmetric division of self-renewing mammary stem cells and mammary tumorigenesis (2014) J Clin Invest. doi:10.1172/JCI73351.

 

 

 

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