Interdisciplinary Life Science - PULSe Great research is a matter of choice

Dorothy Teegarden

Dorothy Teegarden Profile Picture

Professor Lead, Cancer Prevention and Control Program, Oncological Sciences Center
B.S. Biology Antioch College Ph.D. Human Nutrition and Nutritional Biology, University of Chicago


Contact Info:

dteegard@purdue.edu
765-494-8246


Training Group(s):
Molecular Signaling and Cancer Biology


Current Research Interests:

Nutrition and CancerVitamin D status is associated with a reduced incidence of several cancers, including prostate, colon and breast cancer. Dr. Teegarden’s laboratory is investigating the role and the mechanism of vitamin D metabolites in regulation of proteins during cancer progression in breast cancer. Currently, the mechanism by which 1,25 dihydroxyvitamin D regulates hypoxia inducible factor-1alpha is being investigated in breast cell model systems. In addition, the signaling pathways and the role of the nuclear vitamin D receptor mediating its effects are being explored.

Calcium, Dairy Products and Body CompositionOur laboratory was one of the first to publish results demonstrating a negative correlation between dairy product or calcium intake and body fat in 2000. We have completed multiple single center clinical trials, several multi-center trials, and a series of cell culture mechanistic studies to investigate this area. Further, the regulation of insulin resistance by 1,25-dihydroxyvitamin D and parathyroid hormone are also being investigated in her laboratory. We are currently investigating the independent roles of dietary calcium and vitamin D on muscle and insulin resistance particularly in cell models and animal models.  



Selected Publications:

Li J, Byrne ME, Chang E, Jiang Y, Donkin SS, Buhman KK, Burgess JR and Teegarden D. (2008) 1±,25-dihydroxyvitamin D hydroxylase in adipocytes, J Steroid Biochem 112:122-126..

Chang E, Donkin SS, and Teegarden D (2009) Parathyroid Hormone Suppresses Insulin Signaling in Adipocytes. Mol Cell Endo, in press.

Siddiqui SMK, Chang E, Li J, Burlage C, Zou M, Buhman KK, Koser S, Donkin SS and Teegarden D. (2008) Dietary intervention with vitamin D, calcium and whey protein reduced fat mass and increased lean mass in rats. Nutrition Res 28:783-790.

Taber L, Adams LS, D. Teegarden. Mechanisms of nuclear vitamin D receptor resistance Harvey-ras transfected cells. J Nutr Biochem, in press.

Li J, Fleet JC, and D. Teegarden. Activation of rapid signaling pathways does not contribute to 1a,25-dihydroxyvitamin D3-induced growth inhibition of mouse prostate epithelial progenitor cells. J Cellular Biochem, in press.

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