Interdisciplinary Life Science - PULSe Great research is a matter of choice

Elizabeth J. Taparowsky

Elizabeth J. Taparowsky Profile Picture

Professor of Biological Sciences
Ph.D. - 1982 - Brown University


Contact Info:

taparows@purdue.edu
765-494-7978


Training Group(s):
Immunology and Infectious Diseases
Molecular Signaling and Cancer Biology
Chromatin and Regulation of Gene Expression


Current Research Interests:

The precise regulation of gene transcription is critical to the growth and development of all organisms and thus is frequently targeted by mutations accumulating in neoplasms progressing towards a cancerous state. Our group studies the structure, function, and regulation of a number of mammalian transcription factors whose activities are enhanced in human cancer (e.g., Myc) or, alternatively, whose abilities to induce terminal differentiation can restrict the progression of cancer (e.g., MyoD). In recent years, projects in the lab have been focused on BATF, a member of the Activator Protein-1 (AP-1) family of basic leucine zipper (bZIP) transcription factors that functions as a negative regulator of AP-1 mediated transcription. Our studies have shown that BATF efficiently blocks cell growth initiated by mitogen exposure, Ras oncoprotein activation, or viral infection. Using biochemical and biophysical approaches, we have identified a number of BATF post-translational modifications that are utilized by cells to modulate the activities of BATF as a growth regulator. We have generated a number of mouse models in which the level of BATF protein expression in specific tissues is altered and are using these models to investigate the impact of BATF on development, differentiation, and on experimentally induced disease. These genetically modified animals also provide the starting material for microarray analyses that are being used to profile gene expression changes associated with BATF and to identify BATF target genes. The goal of our work is to fully characterize molecular regulators of transcription and apply that information towards the design of strategies to control the aberrant growth of disease states such as cancer.



Selected Publications:

Deppmann, C.D., Alvania, R.S., & Taparowsky, E.J. (2006). Cross-species annotation of basic leucine zipper factor interactions: Insight into the evolution of closed interaction networks. Mol. Biol. & Evol. 23, 1-13.

Vinson, C., Acharya, A. and Taparowsky, E.J. (2006). Deciphering bZIP transcription factor interactions in vitro and in vivo. Biochem. Biophys. Acta. 1759, 4-12.

Mitin, N.Y., Konieczny, S.F., & Taparowsky, E.J. (2006). Ras and the RAIN/RasIP1 effector. Methods in Enzymology, 407, 322-335.

Liu, H., Deng, X., Shyu, Y.J., Li, J.J., Taparowsky, E.J., & Hu, C-D. (2006). Mutual regulation c-Jun and ATF2 by transcriptional activation and subcellular localization. EMBO J., 25, 1058-1069.

Thornton, T. M., Zullo, A. J., Williams, K. L. & Taparowsky, E. J. (2006). Direct manipulation of activator protein-1 controls thymocyte proliferation in vitro. Eur. J. Immunol. 36,160-169.

Tuveson, D.A., Zhu, L., Gopinathan, A., Willis, N.A., Kachatrian, L., Grochow, R., Pin, C.L., Mitin, N.Y., Taparowsky, E.J., Gimotty, P.A., Hruban, R.H., Jacks, T. and Konieczny, S.F. (2006). Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma. Cancer Res. 66, 242-247.

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