Interdisciplinary Life Science - PULSe Great research is a matter of choice

Ann E. Rundell

Ann E.  Rundell Profile Picture

Assistant Professor of Biomedical Engineering
Ph.D. Electrical Engineering, Purdue University, December 1997

Contact Info:

Training Group(s):
Molecular Signaling and Cancer Biology

Current Research Interests:

Dr. Rundell's Systems Biology research laboratory integrates experiments with mathematical modeling and engineering analysis to understand and control cellular processes relevant to health and medical applications. Successfully achieving these objectives depends on the close coupling of the theoretical work with the experiment design, data collection and interpretation. Current projects relate to the ischemia/reperfusion injury responses of renal cells and cardiac myocytes, TCR-initiated signaling pathways of T cells, and the cell cycle of leukemic cells. The complexity and uncertainty associated with these cell responses limits our ability to understand the signaling pathways and control the cell responses without the use of an integrated analytical approach. Dr. Rundell's research translates the current understanding to mathematical models that reflect the intracellular molecular dynamics and cell responses observed through laboratory experiments, applies nonlinear control and sensitivity analyses to the resulting models to evaluate hypotheses for feasibility and design of potential therapeutic strategies.

Selected Publications:

E. Sherer, R.E. Hannemann, A. Rundell, D. Ramkrishna, " Estimation of likely cancer cure using first and second order product densities of population balance models", accepted for publication, Annals of Biomedical Engineering, 2007

Russ, A. L., K. M. Haberstroh, and A. E. Rundell, " Experimental Strategies to Improve In Vitro Models of Renal Ischemia", accepted for publication in Experimental and Molecular Pathology, 2007.

Y. Zheng, A. Rundell, "Comparative Study of Parameter Sensitivity Analyses of the TCR-activated Erk-MAPK Signaling Pathway ", IEE Proceedings Systems Biology 153:201-211, 2006.

L. A. Geddes, R. A. Roeder, A. E. Rundell, M. P. Otlewski, A. E. Kemeny, A. E. Lottes, The Natural Biochemical Changes During Ventricular Fibrillation With CPR and the Onset of PD-PEA, American Journal of Emergency Medicine, 24(5):577-581, 2006.

E. Sherer, R.E. Hannemann, A. Rundell, D. Ramkrishna, "Analysis of Resonance Chemotherapy in Leukemia Treatment via Multi-Staged Population Balance Models", Journal of Theoretical Biology, Vol 240, pp 648-661, 2006.

Y. Zheng,V. Balakrishnan, G. Buzzard, R. Geahlen, M. Harrison, A. Rundell, "Modeling and Analysis of Early Events in T Lymphocyte Antigen-Activated Intracellular-Signaling Pathways", Journal of Computational and Applied Mathematics, solicited submission for special edition on Immunology, 184: 320-341, 2005.

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