Interdisciplinary Life Science - PULSe Great research is a matter of choice

Michael G. Rossmann

Michael G.  Rossmann Profile Picture

Hanley Distinguished Professor of Biological Sciences
National Academy of Sciences; Ph.D., Glasgow (Scotland), 1956

Contact Info:

Training Group(s):
Biomolecular Structure and Biophysics
Membrane Biology
Immunology and Infectious Diseases

Current Research Interests:

We use X-ray crystallography, cryo electron microscopy and molecular biology to study the three dimensional structures of viruses and their component proteins.

The goal is to determine how these molecules or molecular assemblies function. In particular, we are studying various animal and bacterial viruses.

Selected Publications:

Li, L, S.-M. Lok, I.-M. Yu, Y. Zhang, R. J. Kuhn, J. Chen, M. G. Rossmann. 2008. The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 319:1830-1834.

Morais, M. C., J. S. Koti, V. D. Bowman, E. Reyes-Aldrete, D. L. Anderson, M. G. Rossmann. 2008. Defining molecular and domain boundaries in the bacteriophage f29 DNA packaging motor. Structure, 16:1267-1274.

Zhang, P., S. Mueller, M. C. Morais, C. M. Bator, V. D. Bowman, S. Hafenstein, E. Wimmer, M.G. Rossmann. 2008. Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc. Natl. Acad. Sci. U.S.A. 105:18284-18289.

Sun, S., K. Kondabagil, B. Draper, T. I. Alam, V. D. Bowman, Z. Zhang, S. Hedge, A. Fokine, M. G. Rossmann, V. B. Rao. 2008. The structure of the phage T4 DNA packaging motor suggests a mechanism dependent on electrostatic forces. Cell 135:1251-1262.

Aksyuk, A. A., P. G. Leiman, L. P. Kurochkina, M. M. Schneider, V. A. Kostyuchenko, V. V. Mesyanzhinov, M. G. Rossmann. 2009. The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria. EMBO J., 28:821-829.

Xiao, C., Y. G. Kuznetsov, S. Sun, S. L. Hafenstein, V. A. Kostyuchenko, P. R. Chipman, M. Suzan-Monti, D. Raoult, A. McPherson, M. G. Rossmann. 2009. Structural studies of the giant Mimivirus. PLoS Biology, 7:958-966.

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