Interdisciplinary Life Science - PULSe Great research is a matter of choice

P. Veeraraghavan Ramachandran

P. Veeraraghavan Ramachandran Profile Picture

Professor of Chemistry
Ph. D. Indian Inst. Technol. Kanpur


Contact Info:

chandran@purdue.edu
765-494-5303


Training Group(s):
Chemical Biology
Integrative Neuroscience


Current Research Interests:

Design and syntheses of complex molecular targets for the treatment of cancer, inflammation, and central nervous system disorders. Our current efforts focus on (1) the preparation of fluorinated analogs of the potent tubulin polymerizing agent, (-)-dictyostatin (2) the synthesis and biology of several fluorinated carbohydrates and nucleosides for the treatment of pancreatic cancer in collaboration with Indiana University School of Medicine. (3) synthesis of optically active GABA agonists/antagonists/potentiators and assay on various ion channels and GABA receptors for the treatment of epilepsy, neuropathic pain, and addiction through collaborations (Purdue Medicinal Chemistry Department and the Stark Neurosciences Research Institute).



Selected Publications:

Natural and Synthetic alpha,beta-Unsaturated Carbonyls for NF-kappaB Inhibition. Ramachandran, P. V.; Yip-Schneider, M. T.; Schmidt, C. M. Fut. Med. Chem. 2009, 1, 179.

Asymmetric Aldol Reaction with Diisopinocampheyl Enolborinates of Propionates. Ramachandran, P. V.; Pratihar, D. Org. Lett. 2009, 11, 1467.

Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Peng, X. Q.; Li, X.; Li, J.; Ramachandran, P. V.; Gagare, P. D.; Pratihar, D.; Ashby, C. R.; Gardner, E. L.; Xi, Z. X. Drug and Alcohol Dependence, 2008, 97, 207.

Convenient Synthesis of Stable Aldimine-Borane Complexes, Chiral delta-Amino Alcohols, and gamma-Substituted GABA Analogs from Nitriles. Ramachandran, P. V.; Biswas, D. Org. Lett. 2007, 9, 3025.

Total Synthesis of Potential Antitumor Agent, (-)-Dictyostatin. Ramachandran, P. V.; Srivastava, A.; Hazra, D. Org. Lett. 2007, 9, 157.

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