Seema Mattoo

Active Mentor - currently hosting PULSe students for laboratory rotations and recruiting PULSe students into the laboratory; serves on preliminary exam committees

Current Research Interests:

Cell signaling and post-translational modifications mediated by Fic proteins. Projects include: 1) Microbial pathogenesis. 2) Parkinson's Disease. 3) Cancer

Selected Publications:

1. C. A. Worby* and S. Mattoo*, R. P. Kruger, L. B. Corbeil, A. Koller, J. C. Mendez, B. Zekarias, C. S. Lazar, and J. E. Dixon. 2009. The Fic domain: Regulation of cell signaling by adenylylation. Molecular Cell. 34: 93. [PMC2820730]. *Equal contribution
2. A. Sanyal, A. J. Chen, E. S. Nakayasu, C. S. Lazar, E. A. Zbornik, C. A. Worby, A. Koller, and S. Mattoo*. 2015. A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. Journal of Biological Chemistry. 290: 8482 [PMID: 25601083]
3. A. Sanyal, S. Dutta, A. Chandran, A. Koller, A. Camara, B. G. Watson, R. Sengupta, D. Ysselstein, P. Montenegro, J. R. Cannon, J-C. Rochet, and S. Mattoo*. 2019. Alpha-Synuclein is a target of Fic-mediated adenylylation/AMPylation: Implications for Parkinson’s Disease. Journal of Molecular Biology. pii: S0022-2836(19): 30233-5. doi: 10.1016/j.jmb.2019.04.026.
4. Camara A, George A, Hebner E, Mahmood A, Paluru J, Mattoo S*. 2020. A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD. International Journal of Molecular Sciences. 21(19): 7128. doi: 10.3390/ijms21197128.
5. R. Sengupta, M. J. Poderycki and S. Mattoo*. CryoAPEX – a tool for subcellular localization of membrane proteins in cryofixed-chemically fixed cells using electron tomography. 2019. Journal of Cell Science. 132 (6). DOI:10.1242/jcs.222315.