Interdisciplinary Life Science - PULSe Great research is a matter of choice

Sandro Matosevic

Sandro Matosevic Profile Picture
Assistant Professor, Industrial and Physical Pharmacy
Contact Info:

765-494-1400

sandro@purdue.edu


Training Group(s):
Immunology and Infectious Diseases


Current Research Interests:

My research is in the area of cancer immunotherapy and nanomedicine, and focuses on developing translational tools to reprogram, control and direct the therapeutic behavior of immune cells and their interaction with the tumor microenvironment by combining approaches in cell therapy, genetic engineering, nanotechnology and biomaterials via three related and distinct project areas:

 

(1) Reprogramming of immune cell effector function via genetic and molecular modulation of a sophisticated repertoire of activating and inhibitory receptors by understanding the innate immune responses to metabolic interventions and the tumor microenvironment.

 

(2) Development of targeted protein, small molecule and nucleic acid-based nanomedicines as new immunotherapies to target immune cell activation and metabolic reprogramming in response to viral infection

 

(3) Rational engineering of novel biomaterial-based cryopreservation solutions to remove acute toxicity, improve safety and avoid morphological and epigenetic changes to primary cells and tissues post-infusion associated with the post-thaw presence of DMSO.



Selected Publications:

Pasley S, Zylberberg C, Matosevic S. Natural killer-92 cells maintain cytotoxic activity after long-term cryopreservation in new DMSO-free media. Immunology Letters, 2017, In press.


Zylberberg C, Gaskill K, Pasley S, Matosevic S. Engineering liposomal nanoparticles for targeted gene therapy. Gene Therapy, 2017, 24(8):441-452.


Zylberberg C and Matosevic S. Bioengineered liposome-scaffold composites as therapeutic delivery systems. Therapeutic Delivery, 2017, 8(6):425-445.


Zylberberg C and Matosevic S. Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. Drug Delivery, 2016, 23(9):3319-3329.


Knapinska A, Amar S, He Z, Matosevic S, Zylberberg C, Fields G. Matrix metalloproteinases as reagents for cell isolation. Enzyme and Microbial Technology, 2016, 93-94:29-43.


Matosevic S, Paegel BM. Layer-by-layer cell membrane assembly. Nature Chemistry, 2013, 5:958-963.


Matosevic S. State-of-the-art in the development of microfluidic technology toward the synthesis of artificial cells from giant unilamellar vesicles. BioEssays, 2012, 34(11):992-1001.


Matosevic S, Paegel BM. 2011. Stepwise synthesis of giant unilamellar lipid vesicles on a microfluidic assembly line. Journal of the American Chemical Society, 2011, 133(9):2798-2800.

Matosevic S, Lye GJ, Baganz F. Immobilised enzyme microreactor for the quantification of multi-step bioconversions: Characterisation of a de novo transketolase-omega-transaminase pathway to synthesise chiral amino alcohols. Journal of Biotechnology, 2011, 155(3):320-329

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