Interdisciplinary Life Science - PULSe Great research is a matter of choice

Yuk Fai Leung

Yuk Fai Leung Profile Picture

Associate Professor in Biological Sciences
B.Sc., HKUST, 1996
M.Phil., HKUST, 1998
Ph.D., CUHK, 2002


Contact Info:

yleung@purdue.edu
765-496-3153


Training Group(s):
Computational and Systems Biology
Integrative Neuroscience


Current Research Interests:

Retinal degeneration is a group of inherited eye diseases including retinitis pigmentosa and age-related macular degeneration that impair our vision. Although much has been learned about the molecular basis of these diseases, they are still incurable. To expedite discovery of new drugs for these diseases, our group at Purdue University studies zebrafish retinal-degeneration models.

We are currently focused in two research directions:

1. Disease-causing gene network for retinal degeneration

2. Drug discovery for retinal degenerationPlease visit our lab website for further information.



Selected Publications:

Liu Y, Ma P, Cassidy PA, Carmer R, Zhang G, Venkatraman P, Brown SA, Pang CP, Zhong W, Zhang M, Leung YF. Statistical Analysis of Zebrafish Locomotor Behaviour by Generalized Linear Mixed Models. Sci Rep. 2017 Jun 7;7(1):2937.

Ganzen L, Venkatraman P, Pang CP, Leung YF, Zhang M. Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration. Int J Mol Sci. 2017 Jun 2;18(6). pii: E1185.

Hensley MR, Chua RFM, Leung YF, Yang JY, Zhang GJ. Molecular evolution of MDM1, a “duplication-resistant” gene in vertebrates. PLOS ONE. 2016 Sep 22;11(9):e0163229.

Weaver CJ, Leung YF, Suter DM. Expression dynamics of NADPH oxidases during early zebrafish development. J Comp Neurol. 2016 Jul 1;524(10):2130-41.

Hensley M, Cui Z, Chua R, Simpson S, Shammas N, Yang JY, Leung YF, Zhang GJ. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Sci Rep. 2016 Jun 13;6:27816.

Zhang L, Xiang L, Liu Y, Venkatraman P, Chong L, Cho J, Bonilla S, Jin ZB, Pang CP, Ko KM, Ma P, Zhang M, Leung YF. A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration. PLoS One. 2016 Mar 1;11(3):e0149663.

Gao Y, Zhang G, Jelfs B, Carmer R, Venkatraman P, Ghadami M, Brown SA, Pang CP, Leung YF, Chan RH, Zhang M. Computational classification of different wild-type zebrafish strains based on their variation in light-induced locomotor response. Comput Biol Med. 2016 Feb 1;69:1-9.

Liu Y, Carmer R, Zhang G, Venkatraman P, Brown SA, Pang CP, Zhang M, Ma P, Leung YF. Statistical analysis of zebrafish locomotor response. PLOS ONE. 2015; 10(10): e0139521.

Bishop B, Ho KK, Tyler K, Smith A, Bonilla S, Leung YF, Ogas J. The chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio. Biochim Biophys Acta. 2015 Jun 17;1849(8):1040-1050.

Gao Y, Chan RHM, Chow TWS, Zhang L, Bonilla S, Pang CP, Zhang M, Leung YF. A high-throughput zebrafish screening method for visual mutants by light-induced locomotor response. IEEE/ACM Trans Comput Biol Bioinform. 2014 Jul-Aug;11:693-701

Zhang L, Bonilla S, Zhang Y, Leung YF. p35 promotes the differentiation of amacrine cell subtype in the zebrafish retina under the regulation of egr1. Dev Dyn. 2014 Feb;243(2):315-23. 

Zhang L, Ma P, Collery R, Trowbridge S, Zhang M, Zhong W, Leung YF. Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. Mol Vis. 2014 Jan 6;20:56-72.

Zhang Y, Bonilla S, Chong L, Leung YF. Irx7, a Smarca4-regulated gene for retinal differentiation, regulates other genes controlled by Smarca4 in zebrafish retinas. Gene Expr Patterns. 2013 Jun-Jul;13:177-82.

Zhang L, Cho J, Ptak D, Leung YF. The role of egr1 in early zebrafish retinogenesis. PLOS ONE. 2013; 8(2): e56108.

Li Z, Zhang L, Leung YF. Use of the zebrafish model to study refractive error. Expert Rev Ophthalmol. 2013; 8(1):1-3. (Invited Editorial Article)

Zhang L, Chong L, Cho J, Liao PC, Shen F, Leung YF. Drug Screening to Treat Early-Onset Eye Diseases: Can Zebrafish Expedite the Discovery? Asia Pac J Ophthalmol (Phila). 2012 Nov-Dec;1(6):374-83. (Invited Review)

Li Z, Ptak D, Zhang L, Walls EK, Zhong W, Leung YF. Phenylthiourea specifically reduces zebrafish eye size. PLoS ONE. 2012;7(6):e40132.

Zhang Y, Yang Y, Trujillo CM, Zhong W, Leung YF. The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper development of both inner and outer nuclear layers and formation of retinal lamination. PLoS ONE. 2012;7(4): e36145.

Hensley MR, Hassenplug E, McPhail R, Leung YF. ZeBase: An open-source relational database for zebrafish laboratories. Zebrafish. 2012;9(1):44-9.

Hensley MR, Emran F, Bonilla S, Zhang L, Zhong W, Grosu P, Dowling JE, Leung YF. Cellular Expression of Smarca4 (Brg1)-regulated Genes in Zebrafish Retinas. BMC Dev Biol. 2011 Jul 14;11(1):45.

Zhang L, Leung YF. Microdissection of Zebrafish Embryonic Eye Tissues. J. Vis. Exp. 2010; 40. pii: 2028.

Hensley MR, Leung YF. A Convenient Dry Feed for Raising Zebrafish Larvae. Zebrafish. 2010; 7:219-31.

Leung, Y.F., Ma, P., Link, B.A., Dowling, J.E. 2008. Factorial microarray analysis of zebrafish retinal development. Proc Natl Acad Sci U S A. 105. 35. 12909-12914.

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