Interdisciplinary Life Science - PULSe Great research is a matter of choice

Tonglei Li

Tonglei Li Profile Picture


Contact Info:

Training Group(s):
Computational and Systems Biology

Current Research Interests:

We have been pursuing drug delivery for cancer therapy and diagnosis that is built upon a platform of drug nanocrystals. The motivation stems from the fact that tumor-targeted delivery of cytotoxic drugs remains a considerable challenge in cancer treatment. Because a majority of anticancer drugs are poorly soluble in water, the common approach resorts to solubilization of the drug using lipophilic chemicals encapsulated in a hydrophilic shell; when a targeting moiety is used, it is often chemically linked to the shell. Such a paradigm suffers inherited limitations preventing the desired tumor-targeting specificity and treatment outcome. Our approach to deliver poorly-soluble drugs as nanosized crystals requires no solubilization or encapsulation chemicals. In addition, nanocrystals permit the exploration of the enhanced permeation and retention (EPR) effect of solid tumors in order to achieve better tumor targeting. More importantly, we are developing so-called nanosized hybrid crystals for theranostic purposes.

Selected Publications:

Christin P. Hollis, Heidi L. Weiss, Markos Leggas, B. Mark Evers, Richard A. Gemeinhart, and Tonglei Li, Biodistribution and Bioimaging Studies of Hybrid Paclitaxel Nanocrystals: Lessons Learned of the EPR Effect and Image-Guided Drug Delivery, Journal of Controlled Release, 2013, ASAP

Christin P. Hollis, Heidi L. Weiss, B. Mark Evers, Richard A. Gemeinhart, and Tonglei Li, In Vivo Investigation of Hybrid Paclitaxel Nanocrystals with Dual Fluorescent Probes for Cancer Theranostics, Pharmaceutical Research, 2013, DOI:10.1007/s11095-013-1048-x

Rongsheng Zhao, Christin P. Hollis, Hua Zhang, Lili Sun, Richard A. Gemeinhart, and Tonglei Li, Hybrid Nanocrystals: Achieving Concurrent Therapeutic and Bioimaging Functionalities Toward Solid Tumors, Molecular Pharmaceutics, 8:1985-1991, 2011, DOI:10.1021/mp200154k

Hua Zhang, Christin P. Hollis, Qiang Zhang, and Tonglei Li, Preparation and Antitumor Study of Camptothecin Nanocrystals, International Journal of Pharmaceutics, 415:293-300, 2011, DOI: 10.1016/j.ijpharm.2011.05.075

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