Interdisciplinary Life Science - PULSe Great research is a matter of choice

Edward A. Fox

Edward A. Fox Profile Picture

Associate Professor of Psychological Sciences
Ph.D., Purdue University


Contact Info:

foxe@purdue.edu
765-494-5917


Training Group(s):
Integrative Neuroscience


Current Research Interests:

How do we make decisions about what we eat - how much we eat, when we eat, or how often we eat? One neural system important in making these decisions is the component of the autonomic nervous system carried by the vagus nerve. Currently, a major focus for us is the sensory component of the vagus nerve because it is one of the most significant inputs for regulating metabolism and food intake. Traditional methods have not provided a means for independently manipulating the numerous vagal sensory pathways to determine their functions. Thus, we are taking advantage of mouse genetics and transgenic technology in combination with nerve mapping, immunohistochemical methods, and sophisticated behavioral methods to dissect the functions of these pathways



Selected Publications:

Murphy, M. C. & Fox, E. A. (2010). Mice deficient in brain-derived neurotrophic factor have altered development of vagal gastric sensory innervation. Journal of Comparative Neurology, 518(15), 2934-2951.

Biddinger, J. E. & Fox, E. A. (2010). Meal parameters and vagal gastrointestinal afferents in mice that experienced early postnatal overnutrition. Physiology and Behavior, 101, 184รข€“191.

Fox, E. A. & McAdams, J. (2010). Smooth muscle-specific expression of neurotrophin-3 in the embryonic and neonatal gastrointestinal tract of the mouse. Cell and Tissue Research, 340(2), 267-286.

Fox, E. A., & Murphy, M. C. (2008). Factors regulating vagal sensory development: potential role in obesities of developmental origin. Physiology and Behavior, 94, 90-104.

Fox, E. A. & Byerly, M. S. (2004). A mechanism underlying mature onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutant mice. American Journal of Physiology, 286, R994-R1004.

Fox, E. A., Phillips, R. J., Baronowsky, E. A., Byerly, M. S., Jones, S. & Powley, T. L. (2001). Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety. Journal of Neuroscience 21:8602-8615.

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