Interdisciplinary Life Science - PULSe Great research is a matter of choice

Shawn S. Donkin

Shawn S. Donkin Profile Picture

Professor and Assistant Dean for Agricultural Research and Graduate Education
PhD, University of Wisconsin-Madison, 1992
MS, The Pennsylvania State University, 1987
BSc, McGill University (Montreal), 1982
AAgr, Dalhousie University, 1980


Contact Info:

sdonkin@purdue.edu
765-494-4847


Training Group(s):
Chromatin and Regulation of Gene Expression


Current Research Interests:

Research in the Donkin lab explores the control of hepatic function that is pertinent to food animal production, well-being, and human health. This research focuses on control of key enzymes for energy and glucose metabolism in liver and other metabolically dynamic tissues. Our lab has focused on understanding the regulation of pyruvate carboxylase (PC) and phosphoenolpyruvate carboxykinase cytolsolic (PCK1), key enzymes involved in glucose and lipid metabolism during health and disease. We are working to define the role of PC and PCK1 gene promoter regulation and impact on TCA cycle activity during anaplerotic and cataplerotic states. Collaborations with other labs (The Teegarden lab in Nutrition Sciences) explore the role of vitamin D in energy partitioning, body composition, TCA cycle flux, and cancer cell biology.



Selected Publications:

Taheripour P, MA DeFord, EJ Arentson-Lantz, SS Donkin, KM Ajuwon, SC Newcomer. 2014. Impact of excess gestational and post-weaning energy intake on vascular function of swine offspring. BMC Pregnancy Childbirth. 14:405-414

McCann, CC, ME Viner, SS Donkin, HM White. 2014. Hepatic patatin-like phospholipase domain-containing protein 3 sequence, single nucleotide polymorphism presence, protein confirmation, and responsiveness to energy balance in dairy cows. J. Dairy Sci. 97: 5167-5175.

Casey T., J. Crodian, S.S. Donkin, K. Plaut. 2014. Continuously Changing Light-Dark Phase Decreases Milk Yield, Fat, Protein and Lactose in Dairy Cows. J Adv Dairy Res 2:119-121.

Camarillo, IG, L Clah, W Zheng, X Zhou, B Larrick, N Blaize, E Breslin, 2014 . Maternal exercise during pregnancy reduces risk of mammary tumorigenesis in rat offspring. Eur. J. of Cancer Prev. 23: 502-505, 2014

Arentson, E.J., R. Potu, D. Ragland, K. K. Buhman, K. Ajuwon, S. S. Donkin. 2014. Excess pregnancy weight gain and early energy-rich environment programs offspring for indications of metabolic syndrome. Nutrition Research 34: 241-249

Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. 2013. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 32:375-81.

Zheng W, Tayyari F, Gowda GA, Raftery D, McLamore ES, Shi J, Porterfield DM, Donkin SS, Bequette B, Teegarden D. 2013. 1,25-dihydroxyvitamin D regulation of glucose metabolism in Harvey-ras transformed MCF10A human breast epithelial cells. J Steroid Biochem Mol Biol. 138:81-9.

Zheng W, Tayyari F, Gowda GA, Raftery D, McLamore ES, Porterfield DM, Donkin SS, Bequette B, Teegarden D. 2013. Altered glucose metabolism in Harvey-ras transformed MCF10A cells. Mol Carcinog. 54:111-20

Grala TM, Roche JR, Kay JK, Rius AG, White HM, Donkin SS, Littlejohn MD, Snell RG, CV. 2013. The expression of genes involved in hepatic metabolism is altered by temporary changes to milking frequency. J Dairy Sci. 97:838-50

White HM, Koser SL, Donkin SS. 2012. Gluconeogenic enzymes are differentially regulated by fatty acid cocktails in Madin-Darby bovine kidney cells. J Dairy Sci. 95:1249-56.

Zou M, E. J. Arentson, D. Teegarden, S. L. Koser, L. Onyskow, S. S. Donkin 2012. Fructose consumption during pregnancy and lactation induces fatty liver and glucose intolerance in rats. Nutr Res. 32:588-98.

White, H. M., S. L. Koser, and S. S. Donkin. 2012. Regulation of bovine pyruvate carboxylase mRNA and promoter expression by thermal stress. J. Anim. Sci. 90:2979-2987.

White HM, Donkin SS, Lucy MC, Grala TM, Roche JR. 2012. Short communication: Genetic differences between New Zealand and North American dairy cows alter milk production and gluconeogenic enzyme expression. J Dairy Sci. 95:455-459.

White H.M., S. L. Koser, S. S. Donkin. 2011. Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor agonist. J Dairy Sci. 94:3428-3436.

Aschenbach J.R., N. B. Kristensen, S. S. Donkin, H. M. Hammon, G. B. Penner. 2011. Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough. IUBMB Life. 62:869-877.

White H. M., S. L. Koser, S. S. Donkin. 2011. Bovine pyruvate carboxylase 5' untranslated region variant expression during transition to lactation and feed restriction in dairy cows. J Anim Sci. 89:1881-92

White H.M., S. L. Koser, S. S. Donkin. 2011. Characterization of bovine pyruvate carboxylase promoter 1 responsiveness to serum from control and feed-restricted cows. J Anim Sci. 89:1763-8

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