Interdisciplinary Life Science - PULSe Great research is a matter of choice

Meng Deng

Meng Deng Profile Picture

Assistant Professor of Biological Engineering
Ph.D. in Chemical Engineering - University of Virginia; B.E. in Chemical Engineering - Tsinghua University

Contact Info:

Training Group(s):
Immunology and Infectious Diseases

Current Research Interests:

Our research lies at the interface of materials science, micro/nano-scale engineering, and cell biology/medicine. Of particular interest is to develop an integrated research program for both the fundamental understanding of cellular processes in tissue development and engineering effective biomaterial systems for tissue repair and regeneration. Our strategies embrace the mechanistic elucidation of various chemical and topographical cues on cellular processes, and application of advanced biomaterials and matrix technologies at the micro- and nanoscale. For example, advances in polymer science have allowed for the design of biomaterials for a specific medical application, while nanotechnology has provided a robust toolbox for the fabrication of tissue-specific architectures. Our work spans from basic science to translational technology. Specifically, we focus on the three thrust areas: (1) cell engineering, (2) advanced biomaterials, and (3) regenerative engineering. In the area of cell engineering, we are interested in understanding of cellular processes and research effective methods to modulate cell function (e.g., via delivery of inducerons); In the area of advanced biomaterials, we focus on rational design of new polymers and composites by exploiting synthetic chemistry and study of cell-material interactions. In the arena of regenerative engineering, we seek to develop effective bioengineered systems with cell-instructive cues for regeneration of complex tissues and tissue interfaces. There are natural synergies among all the three research areas.

Selected Publications:

1. Atala, A., Deng, M., Khan, Y.: Organ Regenerative Engineering: Cell Sources, Considerations, and Strategies. In Regenerative Engineering, Cato Laurencin and Yusuf Khan (Editors), Chapter 8, 183-218, CRC Press, 2013

2. Lv, Q., Deng, M., Ulery, B., Nair, L.S., Laurencin, C.T.: Nano-ceramic composite scaffolds for bioreactorbased bone engineering, Clinical Orthopaedics and Related Research, 2013, 471(8):2422-33 (Cover).

3. Deng, M., James, R., Laurencin, C.T., Kumbar, S.G.: Nanostructured Polymeric Scaffolds for OrthopaedicRegenerative Engineering, IEEE Transactions on Nanobioscience, 2012, 11(1):3-14

4. Deng, M., Kumbar, S.G., Nair, L.S., Weikel, A.L., Allcock, H.R., Laurencin, C.T.: Biomimetic Structures:Biological Implications of Dipeptide-substituted Polyphosphazene-Polyester Blend Nanofiber Matrices forLoad-bearing Bone Regeneration, Advanced Functional Materials, 2011, 21(14):2641–2651. (Cover).

5. Deng, M., Nair, L.S., Nukavarapu, S.P., Kumbar, S.G., Jiang, T., Weikel, A.L., Krogman, N.R., Allcock,H.R., Laurencin, C.T.: In Situ Porous Structures: A Unique Polymer Erosion Mechanism in BiodegradableDipeptide-based Polyphosphazene and Polyester Blends Producing Matrices for RegenerativeEngineering, Advanced Functional Materials, 2010, 20(17):2794–2806. (Cover)

6. Deng, M., Nair, L.S., Nukavarapu, S.P., Jiang, T., Kanner, W., Li, X., Kumbar, S.G., Weikel, A.L.,Krogman, N.R., Allcock, H.R., Laurencin, C.T.: Dipeptide-based Polyphosphazene and Polyester Blendsfor Bone Tissue Engineering, Biomaterials, 2010, 31(18): 4898-4908.

7. Deng, M., Kumbar, S.G., Wan, Y., Toti, U.S., Allcock, H.R., Laurencin, C.T.: Polyphosphazene Polymersfor Tissue Engineering: an Analysis of Material Synthesis, Characterization and Applications, Soft Matter,2010, 6:3119 - 3132.

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