Interdisciplinary Life Science - PULSe Great research is a matter of choice

Jason Cannon

Jason Cannon Profile Picture

Associate Professor of Toxicology
Ph.D., Toxicology, University of Michigan

Contact Info:

Training Group(s):
Integrative Neuroscience

Current Research Interests:

The main focus of my research group is on identifying novel mechanisms of environmentally induced neurodegeneration.  We are particularly interested in pathogenic interactions between genetic factors and environmental insults.  Ongoing projects are primarily focused on neurotoxicity of heterocyclic amines, which are formed during high temperature meat cooking and environmentally-induced aberrations in autophagy. The major techniques utilized in my lab are: neurobehavioral analysis, stereotaxic infusion, gene therapy/viral vector-mediated gene transfer, neurochemistry (HPLC w/electrochemical detection) and histology/microscopy.  Current funding is from NIEHS/NIH, the Michael J. Fox Foundation and the Showalter Trust.

Selected Publications:

Wise JP, Jr., Cannon JR. Alterations in optineurin expression and localization in preclinical Parkinson’s disease models. Toxicol Sci. 2016;In Press. doi: 10.1093/toxsci/kfw133.

Agim ZS, Cannon JR. Dietary Factors in the Etiology of Parkinson's Disease. Biomed Res Int. 2015:672838. doi: 10.1155/2015/672838. PubMed PMID: 25688361; PMCID: 4320877.

Lee JW, Cannon JR. LRRK2 mutations and neurotoxicant susceptibility. Exp Biol Med (Maywood). 2015;240(6):752-9. doi: 10.1177/1535370215579162. PubMed PMID: 25888648.

Lee JW, Tapias V, Di Maio R, Greenamyre JT, Cannon JR. Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiol Aging. 2015;36(1):505-18. doi: 10.1016/j.neurobiolaging.2014.07.011. PubMed PMID: 25174649.

Griggs AM, Agim ZS, Mishra VR, Tambe MA, Director-Myska AE, Turteltaub KW, McCabe GP, Rochet JC, Cannon JR. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is selectively toxic to primary dopaminergic neurons in vitro. Toxicol Sci. 2014;140(1):179-89. doi: 10.1093/toxsci/kfu060. PubMed PMID: 24718704; PMCID: 4133585.

Full citation list:

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