Interdisciplinary Life Science - PULSe Great research is a matter of choice

Amy Brewster

Amy Brewster Profile Picture

Assistant Professor
Ph.D. University of California-Irvine, 2006

Contact Info:
(765) 494-5075

Training Group(s):
Integrative Neuroscience

Current Research Interests:

My general research interests are to study mechanisms that underlie molecular and structural dendritic alterations, seizures, and behavioral deficits in epilepsy.

Selected Publications:

Kanyshkova T, Pawlowski M, Meuth P, Bender R, Brewster AL, Baumann A, Dub├ę CM, Baram TZ, Pape HC, Budde T. (2009) Postnatal expression patterns of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J Neurosci. 29(27):8847-8857.

Bealer SL, Little JG, Metcalf CS, Brewster AL, Anderson AE. (2010) Autonomic and Cellular Mechanisms Mediating Detrimental Cardiac Effects of Status Epilepticus. Epilepsy Res. 91(1):66-73.

Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, Mukhi S, Parghi D, D'Arcangelo G, Anderson AE. (2011) mTORC1 inhibition prevents epileptogenesis and reverses mossy fiber sprouting in NS-Pten knockout mice. Epilepsia 52(11):2065-2075.

Surges R, Kukley M, Brewster A, R├╝schenschmidt C, Schramm J, Baram TZ, Beck H, Dietrich D. (2012) Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem. Biophys. Res. Commun. 420(1):156-160.

Lugo JN, Brewster AL, Spencer CM, Anderson AE. (2012) Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. Learning and Memory 19(5):182-189.

Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C. (2012) Differential dorso-ventral distributions of Kv4.2 and hyperpolarization-activated cyclic adenosine monophosphate gated channel (HCN) proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. J Biol Chem. 287(21):17656-17661.

Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, Anderson AE. (2013) Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. PLOS ONE 8 (3), e57808

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