Interdisciplinary Life Science - PULSe Great research is a matter of choice

Edward L. Bartlett

Edward L.  Bartlett Profile Picture

Assistant Professor, Departments of Biological Sciences and Biomedical Engineering
Ph.D., University of Wisconsin-Madison, 1999


Contact Info:

ebartle@purdue.edu


Training Group(s):
Integrative Neuroscience


Current Research Interests:

My lab studies the neural responses to sound in the central auditory pathway(auditory thalamus and auditory cortex) through extracellular recordings of the neural activities of single neurons in awake animals and non-invasive recordings of auditory evoked potentials. Neural responses to sound in normal animals versus aged animals or "dyslexic" animals are compared in neuroanatomically identified regions. In addition, the lab studies the cellular and synaptic mechanisms by which neurons generate their in vivo responses by simulating synaptic inputs while recording from individual neurons intracellularly using patch-clamp techniques. This allows for the testing of specific hypotheses about the cellular deficits that are responsible for observed neural deficits in vivo that are correlated with behavioral deficits. The experimental results can then be compared to predictions of computational models of neuronal function in order to refine the models and make further experimental predictions.



Selected Publications:

Wang, X., Lu, T., Bendor, D, and Bartlett, E. (2008) Neural coding of temporal information in auditory thalamus and cortex. Neuroscience, 154: 294-303.

Smith, P. H., E. L. Bartlett, and A. Kowalkowski. (2007) Cortical and collicular inputs to cells in the rat paralaminar thalamic nuclei adjacent to the medial geniculate body. J Neurophysiol, 98: 681-695.

Bartlett, E.L., & Wang, X. (2007) Neural representations of temporally modulated signals in the auditory thalamus of awake primates.J Neurophysiol. 97(2):1005-17.

Smith, P.H., Bartlett, E.L., & Kowalkowski, A. (2006) Unique anatomy and physiology of cells in the rat paralaminar thalamic nuclei adjacent to the medial geniculate body. J. Comp. Neurol., 496(3):314-334.

Bartlett, E.L., & Wang, X. (2005) Long-lasting modulation by stimulus context in primate auditory cortex. J. Neurophys., 94(1), 83-104.

Bartlett, E. L., & Smith, P.H. (2002) Effects of paired-pulse and repetitive stimulation on t halamocortical neurons in the rat medial geniculate body. Neuroscience, 113(4): 957-974.

Bartlett, E.L., Start, J.M., Smith, P.H., & Guillery, R.W. (2000) Comparison of the fine structure of cortical and collicular terminals in the rat remedial geniculate body. Neuroscience, 100(4):811-828.

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