Interdisciplinary Life Science - PULSe Great research is a matter of choice

Molecular Signaling and Cancer Biology


Research includes:

  • Apoptosis
  • Cancer Biology
  • Cell Cycle
  • Cell Differentiation
  • Cell Proliferation
  • Chemokines
  • Growth Factors
  • Lipid Mediators
  • Oncogenes
  • Phosphoproteomics
  • Protein Kinases
  • Protein Phosphatases
  • Protein Phosphorylation
  • Signal Transduction
  • Suppressor Genes
  • Therapeutic Targets in Cancer
  • Transcription Factors

Training Group Mission:

The mission of the Molecular Signaling and Cancer Biology Training Group is to educate the next generation of biomedical scientists in the understanding of the basic processes of molecular signal transduction. This knowledge will be applied to the study of differentiation, development, apoptosis and growth of normal and abnormal (malignant) cells and the treatment of disease states, with a special emphasis on cancer. The group encourages and facilitates development of integrated, interdisciplinary approaches by promoting interactions with faculty representing research areas such as cancer biology, cancer pharmacology, biomedical engineering, and chemical biology. The Training Group provides opportunities for development of independent and critical thinking skills by fostering participation in scientific seminars and research forums and will provide specialized graduate courses in the areas of Signal Transduction and the Molecular Basis of Cancer. These opportunities provide students with a strong foundation in biochemistry, molecular and cellular biology, and cancer biology preparing them for a wide range of career opportunities in academia and industry.


Faculty Membership

Faculty
Research Area
Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation
Mechanism(s) of liver cancer pathogenesis by the Hepatitis B Virus X protein. Signal transduction networks in neuronal development and cancer pathogenesis.
Role of histone methylation in gene expression and oncogenesis
Cancer epigenetics and tumor stem cell biology
Cell and developmental biology, membrane trafficking, molecular genetics, cell polarity
Mitotic function and regulation of the cdc14 protein phosphatase
Interactome based drug discovery: Computational and analytical chemistry techniques to design and verify small molecules drugs and "cells as drugs" for cancer, neurological and immunological disorders.
Chromatin Remodeling and Cancer
Parasitology, Immunology, Cellular Trafficking, Vaccine Development
Regulation of mineral metabolism, molecular actions of vitamin D in calcium metabolism and cancer prevention, gene-environment interactions influencing bone/calcium metabolism or cancer
Environmental and molecular toxicology, genomics, and cytogenetics
Regulation of signal transduction through the Syk protein-tyrosine kinase
Diseases associated with obesity, outcomes following weight loss
Regulation of the cell cycle by ubiquitin-dependent proteolysis; protein mass spectrometry
Investigations into treatments and interventions for skeletal muscle atrophy
Functional genomics and systems biology
Multidrug resistance in human cancer
Molecular biology, cell biology, cancer biology and molecular imaging
Biological roles of miRNAs and their use as cancer therapeutics
Immune cell development, trafficking and effector function
Dietary Control of Adipose Development and Its Function
Bionanotechnology and biosensors
Epigenetic processes that mediate heritable modifications to chromatin
Gene expression during mammalian development; cancer model systems
bioorganic chemistry, bioconjugate chemistry, in vitro evolution, drug discovery
Stem cell biology; Muscle development and regeneration; Signaling regulation of satellite cells; Adipose stem cell; muscle-fat interaction
Understanding how the cell nucleus directs expression and stability of the genome and how tissue architecture influences nuclear organization; development of 3D cell culture and organ-on-a-chip models for discovery of targets and cell nucleus-based readouts in cancer prevention and treatment;
Disease Genomics and Personalized Medicine
Roles of Polo-like kinase 1 and its interacting proteins in cell proliferation and carcinogenesis
Development of targeted therapic and imaging agents for cancer and various inflammatory diseases. Function and molecular organization of the human red blood cell membrane. Novel methods for detection of human pathogens.
In vivo musculoskeletal biomechanics; skeletal adaptation; biological regulation of skeletal structure and mass
Biochemistry, Signal Transduction, Microbiology
MDM2, p53, cerebellar development and tumorigenesis, mouse models of human disease
Physics of light interaction with living tissue
Computational chemistry and biological NMR
Microbial pathogenesis; host-parasite interactions; molecular detection and differentiation of microbial pathogens; recombinant and DNA vaccines
Signal transduction and protein Ser/Thr phosphatases
Control of cellular processes, systems biology, computational cell biology, cardiovascular resuscitation
Ecology of natural systems, ecotoxicology, animal health
Drug Discovery in Cancer and Alzheimer's Disease Using Chemical Biology Tools
Cancer prevention with diet-derived bioactive compounds; pancreatic and breast cancer chemoprevention
Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function
Cell signaling and morphogenesis in the leaf epidermis
Proteomics and biological mass spectrometry
Oncogene expression in eukaryotic cells
Vitamin D and cancer Vitamin D and calcium regulation of body composition
Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation
Signal transduction in development; mechanisms of robustness, cell fate decisions, and tissue patterning by morphogen gradients
Cancer metastasis and development of resistance to targeted molecular therapies.
Signal transduction in cancer biology, early neuronal development and cancer metabolism.
Phytohormone ethylene biosynthesis and its signaling pathway in Arabidopsis thaliana
Cancer biology; Zebrafish cancer Model; Comparative oncogenomics; Evolutionary developmental biology (Evo-Devo)
Protein tyrosine phosphatases (PTPs), structure and function, PTP-mediated cellular signaling mechanisms, roles of PTPs in normal physiology and diseases, chemical biology and drug discovery

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