Interdisciplinary Life Science - PULSe Great research is a matter of choice

Membrane Biology


Research includes:

  • Beta-glucan Synthases
  • Bioenergetics
  • Cell to Cell Communication
  • Cell Wall Synthesis
  • Cellular Energetics
  • Cellulose Synthases
  • Exo/Endocytosis
  • Flip-Flop
  • Glycoprotein Synthesis
  • Glycosyl Transferases
  • Golgi Apparatus
  • Lateral Diffusion
  • Lipid Trafficking
  • Membrane Dynamics
  • Membrane Microdomains
  • Membrane Proteins
  • Membrane-Associated Enzymes
  • Phase Behavior
  • Plant Membranes
  • Plant Polysaccharide Synthesis
  • Protein Trafficking
  • Protein-Lipid Interactions
  • Signaling Platforms
  • Transmembrane Transport

Training Group Mission:

Students in the Membrane Biology training group are educated in the basic and fundamental understanding of cell membranes, their components and how membrane and membrane-associated processes control numerous cellular functions. In addition, students are involved in the transfer of these discoveries into new therapies, biofunctional materials, beneficial agricultural products, and devices for the treatment of human disease. Students work with a multidisciplinary group of faculty from many departments who employ an extensive range of experimental approaches including biochemistry, neurobiology, molecular biology, structural biology, microscopy, biophysical chemistry, analytical and organic chemistry, and engineering. The study of membranes and membrane proteins is a burgeoning and exciting frontier in the life sciences and recent technical advances in the field make significant progress and discovery possible. Students also have the opportunity to interact with other members of the program through seminar courses and research meetings.


Faculty Membership

Faculty
Research Area
Protein trafficking and membrane transport in relation to the processes of cell polarity establishment and carcinogenic transformation
Intestinal lipid metabolism, nutritional biochemistry and physiology, heart disease, obesity
Cell and developmental biology, membrane trafficking, molecular genetics, cell polarity
Membrane biophysics, membrane rapair, Linear and nonlinear optical microscopy, nanomedicine
Development of small molecules, peptides and peptidomimetics for drug discovery, bionanotechnology, and cellular delivery of therapeutic agents
Membrane Biology
Membrane biochemistry, biophysics; structure-function of membrane proteins
Fatty acid metabolism, physiology, and control of lipid flux in relation to the cause and the prevention of diabetes and obesity.
Molecular biology of arthropod vectors of disease, with an emphasis on vector-pathogen interactions, characterization of arthropod G protein-coupled receptors, and insecticide discovery.
Multidrug resistance in human cancer
Development of targeted therapic and imaging agents for cancer and various inflammatory diseases. Function and molecular organization of the human red blood cell membrane. Novel methods for detection of human pathogens.
Understanding the regulation of phospholipase C enzymes in disease through macromolecular structure determination and functional assays.
G-protein coupled receptor pharmacology of addiction and neurological disorders
Structure of picornaviruses, parvoviruses, alphaviruses and bacteriophages, fX174, f29, T4; molecular evolution
Development of novel techniques and their application in addressing important problems at biological interfaces
Cytoskeletal function during plant and fungal development and in response to environmental signals
Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function
Neuronal growth cone motility and guidance, cell adhesion and migration, cytoskeletal dynamics, signal transduction, nervous system development
1) development of transiently-stable lipid- and polymer-based carrier systems for targeted drug & gene delivery; 2) development of high-throughput methods for detecting membrane protein activity; 3) development of materials and methods for controlled adsorption and templated protein crystallization
Signaling of G protein-coupled receptors with an emphasis on dopamine receptors and adenylate cyclases
Bio-analytical mass spectrometry with focuses on lipids, disulfide linked proteins, and glycans.
Salmonella typhimurium Type III secretion; actin cytoskeleton rearrangements and bacteria-host interactions

Ernest C. Young Hall, Room 170 | 155  S. Grant Street, West Lafayette, IN 47907-2114 | 765-494-2600

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