Interdisciplinary Life Science - PULSe Great research is a matter of choice

Chromatin and Regulation of Gene Expression

Research includes:

  • Biochemistry
  • Chromatin
  • DNA Repair
  • Gene Expression
  • Genomics
  • Nucleic Acids
  • Transcription

Training Group Mission:

Students in this training group work with a diverse group of faculty who employ an extensive range of experimental approaches with the goal of understanding chromatin and regulation of eukaryotic gene expression. Recent advances in the identification of chromatin modifying proteins and in the elaboration of the “histone code hypothesis” illustrate the value of interdisciplinary approaches in gaining insights into this exciting area of research. Students also have the opportunity to examine the effect of chromatin on other DNA-based processes such as replication, recombination, and repair. All students receive broad training in genetic, biochemical, and genome-based approaches in analysis of these fundamental processes.

Faculty Membership

Research Area

Control of eukaryotic gene expression and replication; DNA structure; virus evolution

Mechanism(s) of liver cancer pathogenesis by the Hepatitis B Virus X protein. Signal transduction networks in neuronal development and cancer pathogenesis.

Role of histone methylation in gene expression and oncogenesis
Transcriptional regulation in poxviruses
Reproductive physiology and molecular biology
The genetic basis of reproductive barriers and molecular mechanisms of plant adaptation. Cost effective integration of genomics for comparative and forward genetics research approaches.
Nutritional Biochemistry and Physiology
Chromatin Remodeling and Cancer
Regulation of mineral metabolism, molecular actions of vitamin D in calcium metabolism and cancer prevention, gene-environment interactions influencing bone/calcium metabolism or cancer
Mechanism of the transfer to and expression of the Agrobacterium tumefaciens Ti-plasmid in plant cells
Regulation of DNA methylation in development and disease
Macronutrients, exercise and mitochondria
Molecular biology, cell biology, cancer biology and molecular imaging
Single molecule fluorescence lifetime imaging and fluorescence correlation spectroscopic measurements of epigenetic modification of single living cells, Nanotools and Raman spectroscopy for detecting in vivo phosphorylation, mRNA, and Micro RNA.
DNA microarray technology to investigate the genomic basis of disease, development, and drug toxicity
Biological roles of miRNAs and their use as cancer therapeutics
Epigenetic processes that mediate heritable modifications to chromatin
Gene expression during mammalian development; cancer model systems
Understanding how the cell nucleus directs expression and stability of the genome and how tissue architecture influences nuclear organization; development of 3D cell culture and organ-on-a-chip models for discovery of targets and cell nucleus-based readouts in cancer prevention and treatment;
Epigenetic regulation of transposable elements
Regulation of cell identity, signal transduction, chromatin remodeling
Nutritional Epigenetics, Cancer Epigenetics. Epigenetic mechanisms of vitamins and polyphenols in cancer prevention and therapy. Epigenetic biomarkers for solid tumors.
Oncogene expression in eukaryotic cells
Defining the Molecular Basis for p68 (Dbp2) in Gene Expression and Cellular Proliferation
Chromatin modifying complexes in Drosophila development as a model for neurodegenerative disease and cancer
Maize genetics, genomics, value-added traits
Evolution of eukaryotic chemodiversity using genomics, network biology, and phylogenetics
Signal transduction in cancer biology, early neuronal development and cancer metabolism.

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