Hydration Shell Spectroscopy
Protein structure and function; X-ray crystallography; metalloenzymes; biodegradation of PCBs and related compounds
Membrane biophysics, membrane rapair, Linear and nonlinear optical microscopy, nanomedicine
Membrane biochemistry, biophysics; structure-function of membrane proteins
Functional role deubiquitinating enzymes in cellular pathways implicated in neurodegeneration, such as Alzheimer's disease and Parkinson's disease
Chemical and systems biology as applied to drug discovery; design, synthesis, and evaluation of small molecule modulators of protein interactions; development and application of high content cell analysis screening platforms.
Structural cell biology of infection, immunity, and aging
Protein-DNA interactions and protein engineering of homing endonucleases
Structural basis for RNA function
Macromolecular sequences and the evolution, structure and function of molecules; databases and computational tools for functional genomics
Multidrug resistance in human cancer
Structure of tailed dsDNA bacteriophages and Flaviviruses; Membrane protein structure by 2-D crystallization; Cryo-EM method development; Large scale computing for cryo-EM image processing
Biomechanics of cytoskeleton, cells and tissues; Computational modeling of biological structures
Viral gene expression; virus-host interactions; pathogenesis; virus receptors and virus assembly
StructureFunction relationships of natural product biosynthetic enzymes for combinatorial biosynthesis
Development of targeted therapic and imaging agents for cancer and various inflammatory diseases. Function and molecular organization of the human red blood cell membrane. Novel methods for detection of human pathogens.
Understanding the regulation of phospholipase C enzymes in disease through macromolecular structure determination and functional assays.
Gene-to-Lead Drug Discovery
System-wide Investigation of protein folding, energetics, and ligand binding
Computational chemistry and biological NMR
Spectroscopic techniques to study biological and synthetic systems capable of converting visible light into chemically stored energy
Protein misassembly diseases
Structure of picornaviruses, parvoviruses, alphaviruses and bacteriophages, fX174, f29, T4; molecular evolution
Entry of retroviruses and other enveloped viruses into cells; mechanism of enzymatic phosphoryl transfer
Development and application of NMR techniques with the focus on complex forms of molecular motion
Macromolecular structure and assembly using X-ray crystallography; membrane associated proteins; enzyme structure and function
Proteomics and biological mass spectrometry
1) development of transiently-stable lipid- and polymer-based carrier systems for targeted drug & gene delivery; 2) development of high-throughput methods for detecting membrane protein activity; 3) development of materials and methods for controlled adsorption and templated protein crystallization
Structures and functions of DNA secondary structures as cancer-specific molecular targets;
High-field NMR macromolecule structure determination;
Structure-based rational drug design;
DNA G-quadruplex secondary structures and their interactions with small molecule drugs and proteins;
DNA-targeted anticancer drugs that inhibit transcription factors and topoisomerases.